2023
Sorting secretory proteins
Parchure A, von Blume J. Sorting secretory proteins. ELife 2023, 12: e93490. PMID: 37997893, PMCID: PMC10672786, DOI: 10.7554/elife.93490.Peer-Reviewed Original Research
2022
Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules
Parchure A, Tian M, Stalder D, Boyer C, Bearrows S, Rohli K, Zhang J, Rivera-Molina F, Ramazanov B, Mahata S, Wang Y, Stephens S, Gershlick D, von Blume J. Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules. Journal Of Cell Biology 2022, 221: e202206132. PMID: 36173346, PMCID: PMC9526250, DOI: 10.1083/jcb.202206132.Peer-Reviewed Original ResearchMeSH KeywordsChromograninsCytoplasmic GranulesGolgi ApparatusHumansInsulinInsulin-Secreting CellsProinsulinSecretory VesiclesConceptsTrans-Golgi networkLiquid-liquid phase separationSecretory granulesClient moleculesSecretory storage granulesΒ-cellsMembrane traffickingCargo receptorsPlasma membranePancreatic β-cellsProcessing enzymesCell typesStorage granulesChromogranin proteinsBiogenesisAcidic pHTraffickingGranulesProteinEnzyme
2008
Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells
von Wichert G, Edenfeld T, von Blume J, Krisp H, Krndija D, Schmid H, Oswald F, Lother U, Walther P, Adler G, Seufferlein T. Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells. Cellular Signalling 2008, 20: 925-934. PMID: 18262756, DOI: 10.1016/j.cellsig.2008.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceBiological Transport, ActiveCell Line, TumorChromogranin AGolgi ApparatusHumansMolecular Sequence DataNeuroendocrine TumorsProtein Kinase D2Protein Kinase InhibitorsProtein KinasesRNA, Small InterferingSecretory VesiclesSignal TransductionTrans-Golgi NetworkConceptsTrans-Golgi networkNeuroendocrine tumor cellsGolgi networkFunctional neuroendocrine tumorsProtein kinase D (PKD) familyGolgi apparatusProtein kinase D2Secretory granulesTumor cellsSerine-threonine kinaseHormone secretionNeuroendocrine tumorsChromogranin APerinuclear retentionThreonine kinaseSecretory vesiclesPrecise regulationAutonomous hormone secretionD family