Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2
von Blume J, Knippschild U, Dequiedt F, Giamas G, Beck A, Auer A, Van Lint J, Adler G, Seufferlein T. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. The EMBO Journal 2007, 26: 4619-4633. PMID: 17962809, PMCID: PMC2080801, DOI: 10.1038/sj.emboj.7601891.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCasein Kinase 1 epsilonCasein Kinase IdeltaCell LineCell Line, TumorCell NucleusChlorocebus aethiopsCOS CellsDNA-Binding ProteinsGastrinsHeLa CellsHistone DeacetylasesHumansNuclear Receptor Subfamily 4, Group A, Member 1PhosphorylationProtein Kinase CProtein Kinase D2Protein KinasesReceptor, Cholecystokinin BReceptors, Cytoplasmic and NuclearReceptors, SteroidSerineTranscription FactorsConceptsProtein kinase D2Nuclear accumulationEfficient phosphorylationCritical post-translational modificationSerine/threonine kinaseZinc finger domainPost-translational modificationsSignal transduction pathwaysG protein-coupled receptorsHuman gastric cancer cellsExport machinerySubstrate targetingHDAC7 phosphorylationActivation loopNuclear substratesThreonine kinaseActive kinaseNuclear exportGastric cancer cellsSubcellular compartmentsTransduction pathwaysNuclear localizationPKD familyPKC etaPhosphorylation