2022
Reversibility of brain glucose kinetics in type 2 diabetes mellitus
Sanchez-Rangel E, Gunawan F, Jiang L, Savoye M, Dai F, Coppoli A, Rothman DL, Mason GF, Hwang JJ. Reversibility of brain glucose kinetics in type 2 diabetes mellitus. Diabetologia 2022, 65: 895-905. PMID: 35247067, PMCID: PMC8960594, DOI: 10.1007/s00125-022-05664-y.Peer-Reviewed Original ResearchConceptsType 2 diabetesBrain glucose levelsGlucose levelsHyperglycaemic clampGlycaemic controlBrain glucoseUncontrolled type 2 diabetesType 2 diabetes mellitusConclusions/interpretationThese findingsAims/hypothesisWePlasma glucose levelsLinear mixed-effects regression modelsMixed-effects regression modelsContinuous glucose monitoringMinimal weight changeMagnitude of improvementAge 44.8MethodsEight individualsSD HbA1cDiabetes mellitusCerebral glucoseInterpretationThese findingsWeek interventionRegimen intensificationPost intervention
2020
Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women
Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. American Journal Of Perinatology 2020, 37: 1094-1101. PMID: 32120424, DOI: 10.1055/s-0040-1702988.Peer-Reviewed Original ResearchConceptsDiabetes mellitusLeptin levelsCerebrospinal fluidLean mothersPlasma ratioMaternal cerebrospinal fluidMaternal metabolic environmentElective cesarean deliveryImpact of obesityCord blood insulinEffect of diabetesLow cerebrospinal fluidUncomplicated singleton pregnanciesMaternal plasma ratioArtery plasmaDM mothersCesarean deliveryObese patientsSingleton pregnanciesFetal exposureBlood insulinLower cordPregnant womenMaternal brainLean individuals