Featured Publications
Targeted effects of ketamine on perceptual expectation during mediated learning in rats
Fleming LM, Jaynes FB, Thompson SL, Corlett PR, Taylor JR. Targeted effects of ketamine on perceptual expectation during mediated learning in rats. Psychopharmacology 2022, 239: 2395-2405. PMID: 35389087, PMCID: PMC9296571, DOI: 10.1007/s00213-022-06128-2.Peer-Reviewed Original ResearchConceptsPerceptual expectationsHallucination-like experiencesMemory representationsExpected cueDevaluation phasePerceptual experienceNeural correlatesAssociative learningLearning taskTask phasesExternal outcomesDirect learningLearningEffects of ketamineExpectationsRetrievalConclusionsThese resultsModerate dosePerceptCausal relationshipCuesExperienceRepresentationTaskRecent work
2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipants