2009
Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction
Gourley SL, Howell JL, Rios M, DiLeone RJ, Taylor JR. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learning & Memory 2009, 16: 756-760. PMID: 19926781, PMCID: PMC2788209, DOI: 10.1101/lm.1547909.Peer-Reviewed Original Research
2001
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease
Collier TJ, Sortwell CE, Elsworth JD, Taylor JR, Roth RH, Sladek JR, Redmond DE. Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease. The Journal Of Comparative Neurology 2001, 442: 320-330. PMID: 11793337, DOI: 10.1002/cne.10108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrain Tissue TransplantationCell DifferentiationChlorocebus aethiopsDopamineGraft SurvivalHomovanillic AcidImmunohistochemistryMaleNeostriatumNerve RegenerationNeuritesNeuronsParkinsonian DisordersRecovery of FunctionStem Cell TransplantationStem CellsSubstantia NigraTreatment OutcomeTyrosine 3-MonooxygenaseConceptsSubstantia nigraParkinson's diseaseDA neuronsVentral mesencephalonTyrosine hydroxylaseTH-positive fiber densityEmbryonic DA neuronsEmbryonic dopamine neuronsRostral substantia nigraStriatal DA depletionVentral mesencephalic graftsBasal ganglia circuitryBasal ganglia structuresSuboptimal therapeutic outcomesAfrican green monkeysDA modulationGrafted neuronsVM graftsMesencephalic graftsParkinsonian monkeysSN neuronsDA depletionReplacement therapyDA replacementDA levelsImpaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats
Jentsch J, Taylor J. Impaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats. Neuropsychopharmacology 2001, 24: 66-74. PMID: 11106877, DOI: 10.1016/s0893-133x(00)00174-3.Peer-Reviewed Original ResearchConceptsPCP-treated ratsStimulus-reward associationsNovel instrumental responseInhibitory response controlObsessive-compulsive disorderMore responsesConcurrent discriminationReversal learningFrontostriatal systemIncentive stimuliAffective impairmentsInhibitory controlInstrumental respondingImpaired inhibitionConditioned responseInstrumental responsePCP treatmentResponse controlMental disordersCurrent studyDrug abuseStimuliLearningSubchronic administrationImpulsivity
1999
Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment
Elsworth J, Taylor J, Sladek J, Collier T, Redmond D, Roth R. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment. Neuroscience 1999, 95: 399-408. PMID: 10658619, DOI: 10.1016/s0306-4522(99)00437-6.Peer-Reviewed Original ResearchConceptsHomovanillic acid/dopamine ratioMPTP treatmentStriatal dopamine levelsDopamine levelsDopamine lossDopamine depletionDopamine ratioStriatal subregionsNucleus accumbensCaudate nucleusDopamine concentrationsOne-yearSeverity categoriesDopamine neuron integrityVentromedial caudate nucleusStriatal dopamine lossHomovanillic acid concentrationsStriatal dopaminergic functionMarked increaseNormal motor performancePaucity of dataMetabolic activityNon-human primatesParkinsonian disabilityTetrahydropyridine (MPTP) model
1996
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure
Horger B, Taylor J, Elsworth J, Jatlow P, Roth R. Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Research 1996, 733: 133-137. PMID: 8891259, DOI: 10.1016/0006-8993(96)00783-4.Peer-Reviewed Original ResearchRestoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys. Cell Transplantation 1996, 5: 315-325. DOI: 10.1016/0963-6897(95)02034-9.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatumRestoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys. Cell Transplantation 1996, 5: 315-325. PMID: 8689042, DOI: 10.1177/096368979600500220.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatum