Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudyUnlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex
Groman SM, Lee D, Taylor JR. Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex. Behavioral Neuroscience 2021, 135: 120-128. PMID: 34060870, PMCID: PMC8201418, DOI: 10.1037/bne0000414.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexReinforcement-learning mechanismsDecision-making impairmentsDiverse clinical populationsDecision-making differsNeurocomputational approachOFC dysfunctionNeuroscience techniquesBiobehavioral disordersBehavioral paradigmsClinical populationsBiobehavioral mechanismsAddiction pathologyComputational differencesReinforcement-learning algorithms