2007
Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis
Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ. Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis. Journal Of Pediatric Surgery 2007, 42: 927-933. PMID: 17560196, DOI: 10.1016/j.jpedsurg.2007.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial TranslocationCell LineDisease Models, AnimalEnterocolitis, NecrotizingEscherichia coliEscherichia coli InfectionsImmunity, InnateLipopolysaccharidesMacrophages, PeritonealMaleMiceMice, Inbred C3HMice, KnockoutPeritoneal CavityPeritonitisPhagocytosisPhagosomesSepsisToll-Like Receptor 4ConceptsToll-like receptor 4TLR4 WT micePeritoneal sepsisBacterial clearancePeritoneal cavityReceptor 4Functional Toll-like receptor 4Rate of phagocytosisMacrophage phagocytosisMutant Toll-like receptor 4Impaired bacterial clearanceTLR4 mutant miceSeptic courseIntraperitoneal injectionTLR4 mutantTherapeutic targetSepsis4 Toll like receptor 9 signaling attenuates the responsiveness of toll like receptor 4 to endotoxin in enterocytes
Gribar S, Anand R, Leaphart C, Cavallo J, Kohler J, Dubowski T, Li J, Hackam D. 4 Toll like receptor 9 signaling attenuates the responsiveness of toll like receptor 4 to endotoxin in enterocytes. Journal Of Surgical Research 2007, 137: 152. DOI: 10.1016/j.jss.2006.12.013.Peer-Reviewed Original ResearchReceptor 4
2006
EPIDERMAL GROWTH FACTOR (EGF) ATTENUATES LPS-MEDIATED SIGNALING IN ENTEROCYTES THROUGH REDUCED EXPRESSION OF TOLL LIKE RECEPTOR 4 DURING ENDOTOXEMIC STRESS
Fan J, Leaphart C, Cavallo J, Anand R, Li J, Hackam D. EPIDERMAL GROWTH FACTOR (EGF) ATTENUATES LPS-MEDIATED SIGNALING IN ENTEROCYTES THROUGH REDUCED EXPRESSION OF TOLL LIKE RECEPTOR 4 DURING ENDOTOXEMIC STRESS. Shock 2006, 25: 19. DOI: 10.1097/00024382-200606001-00060.Peer-Reviewed Original ResearchThe expression and function of enterocyte toll like receptor-4 are enhanced by lipopolysaccharide in vitro and during systemic endotoxemia
Cavallo J, Leaphart C, Li-Korotky H, Lo C, Li J, Hackam D. The expression and function of enterocyte toll like receptor-4 are enhanced by lipopolysaccharide in vitro and during systemic endotoxemia. Journal Of Surgical Research 2006, 130: 232. DOI: 10.1016/j.jss.2005.11.198.Peer-Reviewed Original Research