2022
Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features
Drachman R, Colic L, Sankar A, Spencer L, Goldman DA, Villa LM, Kim JA, Oquendo MA, Pittman B, Blumberg HP. Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features. Journal Of Affective Disorders 2022, 303: 331-339. PMID: 35181384, PMCID: PMC9109470, DOI: 10.1016/j.jad.2022.02.047.Peer-Reviewed Original ResearchConceptsSubstance use disordersChildhood Trauma QuestionnaireChildhood maltreatmentBarratt Impulsiveness Scale scoresBipolar disorderAnterior cingulate cortexEmotional childhood maltreatmentElevated mood statesBIS total scoreBilateral orbitofrontal cortexMotor impulsivenessSuicide attemptsOrbitofrontal cortexImpulsiveness scoresMood statesBehavioral dyscontrolCingulate cortexBehavioral constructsTrauma QuestionnaireBrain circuitrySocial behaviorElevated aggressionModest sample sizeBrain regionsSuicide ideation
2020
Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder
Sankar A, Purves K, Colic L, Lippard ETC, Millard H, Fan S, Spencer L, Wang F, Pittman B, Constable RT, Gross JJ, Blumberg HP. Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder. Bipolar Disorders 2020, 23: 152-164. PMID: 32521570, PMCID: PMC7790437, DOI: 10.1111/bdi.12954.Peer-Reviewed Original ResearchConceptsExplicit emotion regulationEmotion regulationBrain responsesMood statesDorsal anterior cingulate cortexEmotion regulation difficultiesHappy facial stimuliFrontal cortex functioningDorsal frontal regionsBipolar disorderAcute mood symptomsAnterior cingulate cortexFunctional MRI dataMajor suicide risk factorsNegative affective symptomsEuthymic mood stateRegional brain responsesFacial stimuliRegulation difficultiesFrontal engagementMOFC responseNegative emotionsLoss of motivationDiminished motivationEuthymic individuals
2019
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies
Schmaal L, van Harmelen AL, Chatzi V, Lippard ETC, Toenders YJ, Averill LA, Mazure CM, Blumberg HP. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies. Molecular Psychiatry 2019, 25: 408-427. PMID: 31787757, PMCID: PMC6974434, DOI: 10.1038/s41380-019-0587-x.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexSuicidal ideationSuicidal thoughtsDorsal PFCDorsal anterior cingulate cortexAnterior cingulate cortexHigh-risk circumstancesBrain alterationsBrain areasLarger sample sizeCingulate cortexMolecular alterationsMental disordersNarrative reviewSuicide thoughtsPrefrontal cortexNeurobiological substratesInhibition of behaviorSuicide attempt behaviorBrain systemsCortexInsulaImpairmentComprehensive reviewLongitudinal design
2012
Integrating Imaging and Genetic Research
Perlis R, Blumberg H. Integrating Imaging and Genetic Research. 2012, 239-252. DOI: 10.1093/med/9780199797608.003.0101.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBipolar disorderCorticolimbic systemAbstract Neuroimaging studiesHomogeneous patient populationAnterior cingulate cortexPatient populationBrain changesClinical practiceCingulate cortexPersonalized treatmentVentral prefrontalNeuroimaging studiesGenetic association studiesConvergence of findingsMolecular mechanismsAssociation studiesGenetic studiesCommon variationDisordersGenetic researchFuture investigationsImaging
2009
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston E, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder. Biological Psychiatry 2009, 66: 516-521. PMID: 19427632, PMCID: PMC2830492, DOI: 10.1016/j.biopsych.2009.03.023.Peer-Reviewed Original ResearchConceptsPerigenual anterior cingulate cortexHealthy comparison subjectsBipolar disorderFunctional magnetic resonance imagingDiffusion tensor imagingFunctional connectivityWhite matterFractional anisotropyHC groupPerigenual anterior cingulateAnterior cingulate cortexMagnetic resonance imagingGray matter structuresRegional fractional anisotropyWhite matter connectivityEmotional processingFunctional connectivity measuresSignificant positive associationBD groupComparison subjectsAnterior cingulateCingulate cortexResonance imagingSignificant associationBrain regions
2003
A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices. JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexBipolar disorderPrefrontal cortexMood statesMagnetic resonance imaging studyHealthy control subjectsAcute mood statesLeft ventral prefrontal cortexResonance imaging studySignal changesDisturbances of attentionFunctional magnetic resonance imaging studyAnterior cingulate cortexBipolar disorder IDorsal anterior cingulateEvent-related functional magnetic resonanceFunctional magnetic resonanceAcute episodeControl subjectsExaggerated increaseFunctional impairmentBlunted activationMood episodesSpecific mood statesPrefrontal abnormalities