2022
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingPregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
2005
The sectored foraging field: A novel design to quantify spatial strategies, learning, memory, and emotion
Hermes GL, Jacobs LF, McClintock MK. The sectored foraging field: A novel design to quantify spatial strategies, learning, memory, and emotion. Neurobiology Of Learning And Memory 2005, 84: 69-73. PMID: 15936684, DOI: 10.1016/j.nlm.2005.02.001.Peer-Reviewed Original ResearchConceptsNatural learning contextSame motor actionAnalysis of cognitionLearning strategiesSpatial navigation taskSpatial strategiesDifferent learning strategiesKinesthetic strategyCognitive performanceCue removalMotor actionsDifferent social ecologiesGroup contextMultiple learning strategiesLearning contextNavigation taskSocial ecologySocial environmentLocal cuesEmotionsCognitionGroup-housed ratsGroup-housed malesStressful environmentsAdulthood