2021
Sex Hormones, Insulin, and Insulin-like Growth Factors in Recurrence of High-Stage Endometrial CancerSex Hormones and Insulin in Endometrial Cancer Recurrence
Merritt MA, Strickler HD, Hutson AD, Einstein MH, Rohan TE, Xue X, Sherman ME, Brinton LA, Yu H, Miller DS, Ramirez NC, Lankes HA, Birrer MJ, Huang GS, Gunter MJ. Sex Hormones, Insulin, and Insulin-like Growth Factors in Recurrence of High-Stage Endometrial CancerSex Hormones and Insulin in Endometrial Cancer Recurrence. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 719-726. PMID: 33622671, PMCID: PMC8026669, DOI: 10.1158/1055-9965.epi-20-1613.Peer-Reviewed Original ResearchConceptsEndometrial cancer recurrenceSex hormonesEndometrial cancerProgesterone receptorCancer recurrenceInsulin/insulin-like growth factor axisRecurrence riskInsulin-like growth factor (IGF) axisInsulin-like growth factorGynecologic Oncology GroupProgression-free survivalEndometrial adenocarcinoma patientsIGF-binding proteinsFuture clinical trialsGrowth factor axisConfidence intervalsIR/IGF1RAdjuvant therapyER positivityIGFBP-3Oncology GroupProspective cohortAdenocarcinoma patientsPretreatment specimensSerum concentrations
2016
Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors
Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes & Control 2016, 27: 737-748. PMID: 27125830, PMCID: PMC4870288, DOI: 10.1007/s10552-016-0751-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiabetes MellitusEndometrial NeoplasmsEndometriumEstrogen Receptor alphaEstrogensFemaleGene ExpressionGonadal Steroid HormonesHumansImmunohistochemistryInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMiddle AgedParityPhosphoproteinsPostmenopausePremenopausePTEN PhosphohydrolaseReal-Time Polymerase Chain ReactionReceptor, IGF Type 1Receptor, InsulinReceptors, ProgesteroneReceptors, SomatomedinRisk FactorsRNA, MessengerConceptsInsulin-like growth factorEndometrial cancer risk factorsCancer risk factorsPostmenopausal womenRisk factorsEndometrial tissueInsulin/insulin-like growth factorRegular nonsteroidal anti-inflammatory drug useNonsteroidal anti-inflammatory drug usePhosphorylated insulin-like growth factorEstrogen receptor-positive tissuesAnti-inflammatory drug useNon-diabetic womenProtein levelsReceptor-positive tissuesNormal endometrial tissuesHigher IGFBP1OC usePostmenopausal endometriumBenign indicationsProgesterone receptorQuantitative real-time PCRHormone axesIGFBP3 expressionHuman endometrium