2012
Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex
Schindler EA, Harvey JA, Aloyo VJ. Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex. Brain Research 2012, 1491: 98-108. PMID: 23123701, PMCID: PMC3559188, DOI: 10.1016/j.brainres.2012.10.057.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAnimalsBehavior, AnimalCerebral CortexEnzyme ActivationEnzyme InhibitorsEstrenesHallucinogensHead MovementsHydrolysisLysergic Acid DiethylamideMaleMicroinjectionsPhosphatidylinositolsPrefrontal CortexPyrrolidinonesRabbitsReceptor, Serotonin, 5-HT2ASerotonin AntagonistsSerotonin Receptor AgonistsSignal TransductionType C PhospholipasesConceptsMedial prefrontal cortexLysergic acid diethylamidePI hydrolysisReceptor antagonistPrefrontal cortexDimethoxy-4Acid diethylamidePhospholipase CDistinct pharmacological propertiesEffects of hallucinogensActivation of PLCTissue prismsSerotonergic receptorsReceptor mechanismsPhosphatidylinositol hydrolysisPharmacological propertiesIntracellular mechanismsPLC inhibitorPLC activationHead bobsTrien-17Receptor signalsHallucinogensNovel findingsAntagonist
2008
Relationship between recovery of frontocortical 5HT2A receptor density and PI hydrolysis after chronic treatment
Schindler E, Aloyo V, Harvey J. Relationship between recovery of frontocortical 5HT2A receptor density and PI hydrolysis after chronic treatment. The FASEB Journal 2008, 22: 621-621. DOI: 10.1096/fasebj.22.2_supplement.621.Peer-Reviewed Original ResearchReceptor densityPI hydrolysisControl levelsRecovery periodRecovery daysChronic drug administrationDOI treatmentSerotonin2A receptorsAgonist DOIChronic treatmentLast injectionDrug AdministrationPharmacologic manipulationPhosphatidylinositol hydrolysisTime pointsVivo studiesFurther studiesTissue slicesDaysReceptorsTreatmentPeriodLevelsMajor signaling systemsAdministration