2023
Development and validation of a novel score to predict brain death after out-of-hospital cardiac arrest
Kitlen E, Kim N, Rubenstein A, Keenan C, Garcia G, Khosla A, Johnson J, Miller P, Wira C, Greer D, Gilmore E, Beekman R. Development and validation of a novel score to predict brain death after out-of-hospital cardiac arrest. Resuscitation 2023, 192: 109955. PMID: 37661012, DOI: 10.1016/j.resuscitation.2023.109955.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestBrain deathCardiac arrestOptimal cutEtiology of arrestDeath risk scoreNon-shockable rhythmOperator characteristic curveHours of arrestCenter cohortIndependent predictorsSulcal effacementUnResponsiveness (FOUR) scoreValidation cohortDevelopment cohortMAIN OUTCOMEHigh riskRisk scoreAcademic centersNovel scoreOHCACohortInternal validationRadiology reportsCharacteristic curve
2018
T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study
Osman G, Rahangdale R, Britton J, Gilmore E, Haider H, Hantus S, Herlopian A, Hocker S, Lee J, Legros B, Punia V, Rampal N, Szaflarski J, Wallace A, Westover M, Hirsch L, Gaspard N. T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study. Clinical Neurophysiology 2018, 129: e25-e26. DOI: 10.1016/j.clinph.2018.04.063.Peer-Reviewed Original ResearchBilateral independent periodic dischargesCase-control studyRetrospective case-control studyElectrographic seizuresBrain injuryPeriodic dischargesPoor outcomePD groupHospital mortality rateAcute brain injuryAnoxic brain injuryCNS infectionsFrequent etiologyLPD groupHemorrhagic strokeClinical correlatesWorse outcomesLevel of alertnessHigh riskBetter outcomesMortality rateControl groupMultivariate analysisSeizuresEEG patternsF80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage
Sheikh Z, Stretz C, Maciel C, Dhakar M, Hirsch L, Gilmore E. F80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage. Clinical Neurophysiology 2018, 129: e96-e97. DOI: 10.1016/j.clinph.2018.04.243.Peer-Reviewed Original ResearchDeep intraparenchymal hemorrhageAnti-seizure drugsDecompressive hemicraniectomyIntraparenchymal hemorrhageThalamic involvementHematoma volumeContinuous EEGClinical seizuresSedative infusionsSurgical interventionInsular involvementPrior historyHigh riskMean hematoma volumeIncidence of seizuresRisk of seizuresRhythmic delta activitySpike-wave dischargesHigher hematoma volumeRetrospective reviewElectrographic seizuresSubdural hemorrhageHead CTHigh incidencePatients
2016
Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes
Maciel CB, Gilmore EJ. Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes. Journal Of Clinical Neurophysiology 2016, 33: 183-195. PMID: 27258441, DOI: 10.1097/wnp.0000000000000268.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageAssociation of seizuresMedication side effectsImpact of seizuresSevere subarachnoid hemorrhageRisk-benefit ratioSeizure prophylaxisAntiepileptic treatmentDifferent time pointsNeurovascular complicationsYounger patientsInterictal patternsHeterogeneous pathophysiologyNeurophysiologic monitoringSubclinical seizuresCortical irritationNew anticonvulsantsTherapeutic dosingTherapeutic approachesHigh riskSide effectsFavorable profileEpileptiform patternsSeizuresBurden quantification
2015
Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring
Gilmore EJ, Gaspard N, Choi HA, Cohen E, Burkart KM, Chong DH, Claassen J, Hirsch LJ. Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring. Intensive Care Medicine 2015, 41: 686-694. PMID: 25763756, DOI: 10.1007/s00134-015-3709-1.Peer-Reviewed Original ResearchConceptsNonconvulsive seizuresSevere sepsisEEG reactivityPeriodic dischargesLate seizuresSOFA scoreAPACHE IIFunctional outcomeContinuous sedationHigh riskLower riskMedical intensive care unitLong-term cognitive outcomesPresence of sedationAPACHE II scoreGood functional outcomeNonconvulsive status epilepticusIntensive care unitContinuous EEG monitoringAcute brain failureAcademic medical centerNew epilepsyII scoreClinical seizuresMedical ICU
2011
Prevention of Shivering During Therapeutic Temperature Modulation: The Columbia Anti-Shivering Protocol
Choi HA, Ko SB, Presciutti M, Fernandez L, Carpenter AM, Lesch C, Gilmore E, Malhotra R, Mayer SA, Lee K, Claassen J, Schmidt JM, Badjatia N. Prevention of Shivering During Therapeutic Temperature Modulation: The Columbia Anti-Shivering Protocol. Neurocritical Care 2011, 14: 389-394. PMID: 21210305, DOI: 10.1007/s12028-010-9474-7.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdultAgedAnticonvulsantsConscious SedationCritical CareDexmedetomidineDose-Response Relationship, DrugFemaleFeverGlasgow Coma ScaleHeart ArrestHumansHypothermia, InducedIntensive Care UnitsIntracranial HypertensionMagnesium SulfateMaleMeperidineMiddle AgedMonitoring, PhysiologicNarcoticsNeuromuscular Nondepolarizing AgentsPropofolProspective StudiesShiveringVecuronium BromideConceptsPatient daysNeurological intensive care unitAnti-shivering agentsTherapeutic temperature modulationTotal patient daysPrevention of shiveringDoses of propofolIntensive care unitBaseline demographic informationNew clinical problemsInduced normothermiaMethodsAll patientsYounger patientsCare unitCumulative doseHigh riskClinical problemPatientsTemperature modulating devicesMore interventionsShiveringBaseline interventionDemographic informationFirst agentYoung men