1999
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway C, Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development 1999, 13: 2059-2071. PMID: 10465784, PMCID: PMC316957, DOI: 10.1101/gad.13.16.2059.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsBiological EvolutionCell Line, TransformedCloning, MolecularDrosophilaDrosophila ProteinsEnzyme ActivationHumansInsect ProteinsMAP Kinase Kinase Kinase 1Membrane GlycoproteinsMiceMolecular Sequence DataNF-kappa BProtein Processing, Post-TranslationalProtein Serine-Threonine KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Saccharomyces cerevisiaeSignal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsThe Toll-receptor family and control of innate immunity
Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion In Immunology 1999, 11: 13-18. PMID: 10047546, DOI: 10.1016/s0952-7915(99)80003-x.Peer-Reviewed Original ResearchConceptsInducible immune response genesToll receptor familyToll receptorTransduction pathwaysImmune response genesHost defense systemInnate immune recognitionMicrobial pathogensGermline-encoded receptorsNuclear factor-kappaBMolecular patternsDefense systemInnate immunityFactor-kappaBImmune recognitionPathwayReceptorsInsectsMammalsGenesPlantsPathogensExpressionKappaBFamily
1998
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProteinNF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh S, May M, Kopp E. NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses. Annual Review Of Immunology 1998, 16: 225-260. PMID: 9597130, DOI: 10.1146/annurev.immunol.16.1.225.Peer-Reviewed Original ResearchConceptsNF-kappa BNF-kappa B/IGeneration of knockoutTranscription factor NF-kappa BFactor NF-kappa BAnti-apoptotic proteinsConserved mediatorInducible phosphorylationRel proteinsB proteinB familyOrganism's responseCell deathNormal developmentProteinNF-kappaB actB complexRecent findingsAdhesion moleculesNumerous cytokinesKinaseDiscoveryPhosphorylationCytosol
1995
NF-κB and Rel Proteins in Innate Immunity
Kopp E, Ghosh S. NF-κB and Rel Proteins in Innate Immunity. Advances In Immunology 1995, 58: 1-27. PMID: 7741027, DOI: 10.1016/s0065-2776(08)60618-5.Peer-Reviewed Original Research
1994
Inhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp E, Ghosh S. Inhibition of NF-κB by Sodium Salicylate and Aspirin. Science 1994, 265: 956-959. PMID: 8052854, DOI: 10.1126/science.8052854.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspirinCell LineEnhancer Elements, GeneticGene ExpressionGenes, ReporterHIV Long Terminal RepeatHIV-1HumansImmunoglobulin kappa-ChainsLipopolysaccharidesMiceNF-kappa BPhosphorylationPromoter Regions, GeneticProtein BiosynthesisProto-Oncogene ProteinsSodium SalicylateT-LymphocytesTranscription Factor RelBTranscription FactorsTransfectionTumor Cells, CulturedConceptsNF-kappa BInterleukin-1Anti-inflammatory drug sodium salicylateHuman immunodeficiency virus long terminal repeatNF-kappa B inhibitorSodium salicylateMechanism of actionLong terminal repeatIL-6T cellsNF-κBAspirinAdhesion moleculesVirus long terminal repeatB inhibitorViral genesInhibitionDependent transcriptionInducible expressionSalicylateInflammationTranscription factorsInfectionTerminal repeat