1998
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh S, May M, Kopp E. NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses. Annual Review Of Immunology 1998, 16: 225-260. PMID: 9597130, DOI: 10.1146/annurev.immunol.16.1.225.Peer-Reviewed Original ResearchConceptsNF-kappa BNF-kappa B/IGeneration of knockoutTranscription factor NF-kappa BFactor NF-kappa BAnti-apoptotic proteinsConserved mediatorInducible phosphorylationRel proteinsB proteinB familyOrganism's responseCell deathNormal developmentProteinNF-kappaB actB complexRecent findingsAdhesion moleculesNumerous cytokinesKinaseDiscoveryPhosphorylationCytosol
1994
Inhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp E, Ghosh S. Inhibition of NF-κB by Sodium Salicylate and Aspirin. Science 1994, 265: 956-959. PMID: 8052854, DOI: 10.1126/science.8052854.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspirinCell LineEnhancer Elements, GeneticGene ExpressionGenes, ReporterHIV Long Terminal RepeatHIV-1HumansImmunoglobulin kappa-ChainsLipopolysaccharidesMiceNF-kappa BPhosphorylationPromoter Regions, GeneticProtein BiosynthesisProto-Oncogene ProteinsSodium SalicylateT-LymphocytesTranscription Factor RelBTranscription FactorsTransfectionTumor Cells, CulturedConceptsNF-kappa BInterleukin-1Anti-inflammatory drug sodium salicylateHuman immunodeficiency virus long terminal repeatNF-kappa B inhibitorSodium salicylateMechanism of actionLong terminal repeatIL-6T cellsNF-κBAspirinAdhesion moleculesVirus long terminal repeatB inhibitorViral genesInhibitionDependent transcriptionInducible expressionSalicylateInflammationTranscription factorsInfectionTerminal repeat