2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleNicotineSmoking CessationTobaccoTobacco ProductsTobacco Use DisorderYoung AdultConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2022
Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHeart RateHumansLaboratoriesMaleNicotineSmokersSmokingTobacco Use DisorderYoung AdultConceptsAbuse potentialPositive subjective drug effectsSubjective drug effectsHuman laboratory studiesPositive subjective effectsAttention functionSmoking urgesOvernight abstinencePotential therapeutic effectsEffects of nicotineHeart rate increaseDelivery rateDependent smokersExperimental sessionsSubjective effectsNicotine dependenceIntravenous nicotineBlood pressureSaline infusionAcute effectsTherapeutic effectHeart rateDrug effectsAcute responseCrossover design
2021
The Effects of Inhaled Flavors on Intravenous Nicotine
MacLean RR, Gueorguieva R, DeVito EE, Peltier MR, Parida S, Sofuoglu M. The Effects of Inhaled Flavors on Intravenous Nicotine. Experimental And Clinical Psychopharmacology 2021, 29: 615-624. PMID: 32463279, PMCID: PMC7704548, DOI: 10.1037/pha0000394.Peer-Reviewed Original ResearchMeSH KeywordsElectronic Nicotine Delivery SystemsFlavoring AgentsHumansMentholNicotineSmokersTobacco ProductsYoung AdultConceptsCigarette smokersIntravenous nicotineE-cigarettesYoung adult cigarette smokersSubject cross-over designAdult cigarette smokersMain outcome measuresPeak heart rateHigher following administrationCross-over designAcute rewarding effectsPresent studyFollowing administrationAcute effectsOutcome measuresHeart rateRewarding effectsTobacco cigarettesSmoking urgesRewarding propertiesNicotineAddictive effectsHigher cravingMenthol flavorsThousands of flavorsThreshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamineModulation of “Protective” Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-cigarettes
DeVito EE, Jensen KP, O’Malley S, Gueorguieva R, Krishnan-Sarin S, Valentine G, Jatlow PI, Sofuoglu M. Modulation of “Protective” Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-cigarettes. Nicotine & Tobacco Research 2019, 22: 771-781. PMID: 30995302, PMCID: PMC7368338, DOI: 10.1093/ntr/ntz057.Peer-Reviewed Original ResearchConceptsSubjective drug effectsNicotine-containing e-liquidsSelf-administered more nicotineAversive effectsSingle testing dayE-cigarettesSelf-reported preferencesE-cigarette appealRs16969968 genotypePreliminary findingsUnflavored e-liquidsIndividual differencesDrug effectsAd libitumE-liquidsAversive actionsTobacco productsNicotine effectsLow-risk groupNicotine-free e-liquidsPalatable flavorAversivenessTesting daysNicotinic acetylcholine receptor subunit genesNumber of puffs
2018
Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers
Valentine GW, DeVito EE, Jatlow PI, Gueorguieva R, Sofuoglu M. Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. Journal Of Psychopharmacology 2018, 32: 986-994. PMID: 29788802, PMCID: PMC6329876, DOI: 10.1177/0269881118773972.Peer-Reviewed Original ResearchConceptsPositive subjective effectsPositive subjective responsesIntravenous nicotineNicotine metabolismSubjective effectsNicotine metabolite ratioYoung adult smokersSlower nicotine metabolismTest sessionsSubjective responsesSevere nicotine withdrawalMenthol inhalationNicotine withdrawalAcute effectsAdult smokersWithdrawal severityNicotine infusionRewarding effectsSmokersSmoking urgesChronic exposureMetabolite ratiosAversive effectsMenthol conditionsElectronic cigarettesGalantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Carroll KM, Nich C, DeVito EE, Shi JM, Sofuoglu M. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal Of Clinical Psychiatry 2018, 79: 17m11669. PMID: 29286595, PMCID: PMC5866530, DOI: 10.4088/jcp.17m11669.Peer-Reviewed Original ResearchConceptsComputerized cognitive behavioral therapyStandard methadone treatmentCocaine use outcomesBenefits of galantamineMethadone treatmentCognitive behavioral therapyCognitive functionUse outcomesCommunity-based methadone maintenance programCocaine useStandard methadone maintenance treatmentBehavioral therapyUrine toxicology screenMethadone maintenance treatmentMethadone maintenance programCocaine treatment outcomesNicotinic acetylcholine receptorsCognitive functioningCocaine use disorderMethadone dosingSecondary outcomesToxicology screenMaintenance treatmentClinical trialsMedication administration
2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2014
Hippocampal volume mediates the relationship between measures of pre-treatment cocaine use and within-treatment cocaine abstinence
Xu J, Kober H, Wang X, DeVito EE, Carroll KM, Potenza MN. Hippocampal volume mediates the relationship between measures of pre-treatment cocaine use and within-treatment cocaine abstinence. Drug And Alcohol Dependence 2014, 143: 74-80. PMID: 25115748, PMCID: PMC4165405, DOI: 10.1016/j.drugalcdep.2014.07.007.Peer-Reviewed Original ResearchConceptsCocaine-dependent patientsHippocampal volumeTreatment outcomesCocaine useCocaine use severityCocaine-negative urine samplesGreater hippocampal volumePoor treatment outcomesPatient groupTreatment trialsContinuous abstinenceHigh-resolution magnetic resonance brain imagesTreatment responseIndividualized treatmentHealthy comparison individualsPatientsCocaine abstinenceCocaine dependenceBehavioral therapyCocaine-related cuesMore daysUrine samplesContingency managementSignificant differencesSignificant correlationPretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1. Drug And Alcohol Dependence 2014, 140: 33-41. PMID: 24793365, PMCID: PMC4057888, DOI: 10.1016/j.drugalcdep.2014.03.031.Peer-Reviewed Original ResearchConceptsCannabis-dependent participantsMagnetic resonance imagingCannabis dependenceHC participantsTreatment responseConsecutive abstinenceHealthy comparison menBilateral putamen volumesCannabis-dependent individualsSuccessful treatment outcomeEfficacy of therapeuticsDays of abstinenceVentral striatal activationClinical trialsStriatal functionTreatment outcomesMRI scanningComparison menPutamen volumeResonance imagingBehavioral treatmentBiological markersBrain functionBrain structuresAbstinence
2013
Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase
DeVito EE, Herman AI, Waters AJ, Valentine GW, Sofuoglu M. Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase. Neuropsychopharmacology 2013, 39: 1431-1440. PMID: 24345818, PMCID: PMC3988546, DOI: 10.1038/npp.2013.339.Peer-Reviewed Original ResearchConceptsSubjective drug effectsMenstrual cycle phaseDrug effectsNicotine dependenceMenstrual cycle phase effectsFollicular phase womenSerious public health concernCycle phase effectsSymptoms of withdrawalLuteal phase femalesPublic health concernMenstrual phase differencesNicotine administrationOptimal treatmentIntravenous nicotineLuteal phaseOvernight abstinenceSmoking behaviorCycle phaseNicotine responseGreater physiological responsesBiochemical confirmationHealth concernEffects of sexBetter cognitionGender differences in a clinical trial for prescription opioid dependence
McHugh RK, DeVito EE, Dodd D, Carroll KM, Potter JS, Greenfield SF, Connery HS, Weiss RD. Gender differences in a clinical trial for prescription opioid dependence. Journal Of Substance Use And Addiction Treatment 2013, 45: 38-43. PMID: 23313145, PMCID: PMC3626739, DOI: 10.1016/j.jsat.2012.12.007.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOpioid dependenceClinical trialsOpioid dependence severityPrescription drug dependenceLarge clinical trialsOpioid use outcomesGreater functional impairmentRoute of administrationSubstance use disordersGender differencesGreater psychiatric severityClinical characteristicsMedication doseStudy treatmentOpioid outcomesFunctional impairmentTreatment outcomesPre-treatment differencesPsychiatric severityTreatment retentionUse disordersLegitimate prescriptionDrug dependenceOpioids
2012
Impaired inhibitory control in ‘internet addiction disorder’: A functional magnetic resonance imaging study
Dong G, DeVito EE, Du X, Cui Z. Impaired inhibitory control in ‘internet addiction disorder’: A functional magnetic resonance imaging study. Psychiatry Research 2012, 203: 153-158. PMID: 22892351, PMCID: PMC3650485, DOI: 10.1016/j.pscychresns.2012.02.001.Peer-Reviewed Original ResearchConceptsIAD groupMagnetic resonance imaging studyPrevalent mental health concernAddiction disordersResonance imaging studyFunctional magnetic resonance imaging studyPosterior cingulate cortexMental health concernsImpaired inhibitory controlHealthy controlsHealthy peersInternet addiction disorderCingulate cortexImaging studiesHealth concernDisordersNeurobiological underpinningsInhibitory controlResponse inhibitionNeural correlatesResponse inhibition processesPotential heterogeneityPresent studyGroupDiffusion tensor imaging reveals thalamus and posterior cingulate cortex abnormalities in internet gaming addicts
Dong G, DeVito E, Huang J, Du X. Diffusion tensor imaging reveals thalamus and posterior cingulate cortex abnormalities in internet gaming addicts. Journal Of Psychiatric Research 2012, 46: 1212-1216. PMID: 22727905, PMCID: PMC3650484, DOI: 10.1016/j.jpsychires.2012.05.015.Peer-Reviewed Original ResearchMemantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism
Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology 2012, 222: 129-140. PMID: 22311382, PMCID: PMC3674025, DOI: 10.1007/s00213-011-2628-2.Peer-Reviewed Original ResearchConceptsNMDA receptor antagonistFamily historyFHN subjectsReceptor antagonistFHP subjectsN-methyl-D-aspartate receptor functionReceptor functionIdentical-appearing placeboEffects of memantineFMRI activityNMDA receptor functionCorrect rejectsSingle doseMemantineGo/No-Go taskSeparate daysTemporal regionsCingulate activation
2011
A preliminary study of the neural effects of behavioral therapy for substance use disorders
DeVito EE, Worhunsky PD, Carroll KM, Rounsaville BJ, Kober H, Potenza MN. A preliminary study of the neural effects of behavioral therapy for substance use disorders. Drug And Alcohol Dependence 2011, 122: 228-235. PMID: 22041256, PMCID: PMC3296894, DOI: 10.1016/j.drugalcdep.2011.10.002.Peer-Reviewed Original ResearchConceptsComputer-assisted cognitive behavioral therapyBehavioral therapySubstance use disordersInferior frontal gyrusCognitive behavioral therapyMaintenance of addictionUse disordersSubstance use outcomesCognitive controlFrontal gyrusTest-retest conditionsNeural effectsComponent of treatmentAnterior cingulateImpulse controlNeural systemsSame taskUse outcomesBOLD signalSubstance useSubstance abuseStroopComparison groupRandomized clinical trialsHealthy controls
2010
Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ. Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males. Psychopharmacology 2010, 211: 187-195. PMID: 20495788, PMCID: PMC2892070, DOI: 10.1007/s00213-010-1880-1.Peer-Reviewed Original ResearchConceptsDA synthesisHealthy individualsParkinson's diseaseMale subjectsPlacebo-controlled crossover designCertain psychiatric disordersPunishment processingDA depletionDopamine synthesisHealthy femalesPsychiatric disordersCrossover designFemale subjectsDiseaseNeurotransmitter dopamineGender biasesReward processingThree-way interactionReversal learningSubjectsDepletion procedurePunishment predictionGender differencesSignificant improvement