2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMenHippocampal volume mediates the relationship between measures of pre-treatment cocaine use and within-treatment cocaine abstinence
Xu J, Kober H, Wang X, DeVito EE, Carroll KM, Potenza MN. Hippocampal volume mediates the relationship between measures of pre-treatment cocaine use and within-treatment cocaine abstinence. Drug And Alcohol Dependence 2014, 143: 74-80. PMID: 25115748, PMCID: PMC4165405, DOI: 10.1016/j.drugalcdep.2014.07.007.Peer-Reviewed Original ResearchConceptsCocaine-dependent patientsHippocampal volumeTreatment outcomesCocaine useCocaine use severityCocaine-negative urine samplesGreater hippocampal volumePoor treatment outcomesPatient groupTreatment trialsContinuous abstinenceHigh-resolution magnetic resonance brain imagesTreatment responseIndividualized treatmentHealthy comparison individualsPatientsCocaine abstinenceCocaine dependenceBehavioral therapyCocaine-related cuesMore daysUrine samplesContingency managementSignificant differencesSignificant correlation
2012
Cognitive enhancement as a treatment for drug addictions
Sofuoglu M, DeVito EE, Waters AJ, Carroll KM. Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 2012, 64: 452-463. PMID: 22735770, PMCID: PMC3445733, DOI: 10.1016/j.neuropharm.2012.06.021.Peer-Reviewed Original ResearchConceptsCognitive enhancementBehavioral interventionsExecutive inhibitory controlCognitive impairmentDrug addictionSelective cognitive functionsCurrent illicit drug usersPoor treatment retentionCognitive enhancing agentsSignificant cognitive impairmentSpecific behavioral interventionsChronic drug useCognitive remediationInhibitory controlMarijuana addictionCognitive enhancersBehavioral treatmentCognitive functionDrug use behaviorsMultiple addictionsSubstance usersTreatment retentionInhibition functionFuture researchUse behaviors
2011
A preliminary study of the neural effects of behavioral therapy for substance use disorders
DeVito EE, Worhunsky PD, Carroll KM, Rounsaville BJ, Kober H, Potenza MN. A preliminary study of the neural effects of behavioral therapy for substance use disorders. Drug And Alcohol Dependence 2011, 122: 228-235. PMID: 22041256, PMCID: PMC3296894, DOI: 10.1016/j.drugalcdep.2011.10.002.Peer-Reviewed Original ResearchConceptsComputer-assisted cognitive behavioral therapyBehavioral therapySubstance use disordersInferior frontal gyrusCognitive behavioral therapyMaintenance of addictionUse disordersSubstance use outcomesCognitive controlFrontal gyrusTest-retest conditionsNeural effectsComponent of treatmentAnterior cingulateImpulse controlNeural systemsSame taskUse outcomesBOLD signalSubstance useSubstance abuseStroopComparison groupRandomized clinical trialsHealthy controls