2023
Examining racial differences in smoking outcomes among smokers enrolled in an intravenous nicotine infusion study
Schwartz E, Palmisano A, Gueorguieva R, DeVito E, Sofuoglu M. Examining racial differences in smoking outcomes among smokers enrolled in an intravenous nicotine infusion study. Addictive Behaviors 2023, 140: 107615. PMID: 36640662, PMCID: PMC9911383, DOI: 10.1016/j.addbeh.2023.107615.Peer-Reviewed Original ResearchConceptsSmoking-related illnessesNegative drug effectsNicotine clearanceOvernight abstinenceNicotine infusionDrug effectsMentholated cigarettesWhite individualsBlack individualsAcute pharmacologic effectsSmoking-related morbiditySmoking-related diseasesAdministration of nicotineSmoking-related outcomesSubjective drug effectsShort-term abstinenceLower ratesTrend level differenceLarge racial disparitiesNicotine administrationNicotine dosesTrend-level significancePharmacologic effectsTreatment strategiesOutcome measures
2022
Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquids
2018
Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers
Jensen KP, Valentine G, Buta E, DeVito EE, Gelernter J, Sofuoglu M. Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers. Pharmacology Biochemistry And Behavior 2018, 173: 36-43. PMID: 30107183, PMCID: PMC6125200, DOI: 10.1016/j.pbb.2018.08.004.Peer-Reviewed Original ResearchConceptsAcute heart rate responseHeart rate responseNicotine infusionHigher nicotine metabolite ratioTobacco harm reduction approachesRate responseGreater withdrawal symptomsNicotine metabolite ratioBlood-based biomarkersNicotine delivery systemsWarrants further investigationHarm reduction approachWithdrawal symptomsCardiovascular functionLower nicotine levelsTobacco useMetabolite ratiosNicotine levelsSmokeless productsHigher cortisolSmokersHR effectsStimulatory effectNicotineDemographic characteristicsAcute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers
Valentine GW, DeVito EE, Jatlow PI, Gueorguieva R, Sofuoglu M. Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. Journal Of Psychopharmacology 2018, 32: 986-994. PMID: 29788802, PMCID: PMC6329876, DOI: 10.1177/0269881118773972.Peer-Reviewed Original ResearchConceptsPositive subjective effectsPositive subjective responsesIntravenous nicotineNicotine metabolismSubjective effectsNicotine metabolite ratioYoung adult smokersSlower nicotine metabolismTest sessionsSubjective responsesSevere nicotine withdrawalMenthol inhalationNicotine withdrawalAcute effectsAdult smokersWithdrawal severityNicotine infusionRewarding effectsSmokersSmoking urgesChronic exposureMetabolite ratiosAversive effectsMenthol conditionsElectronic cigarettes