2022
Modafinil does not reduce cocaine use in methadone-maintained individuals
DeVito EE, Poling J, Babuscio T, Nich C, Carroll KM, Sofuoglu M. Modafinil does not reduce cocaine use in methadone-maintained individuals. Drug And Alcohol Dependence Reports 2022, 2: 100032. PMID: 36310662, PMCID: PMC9615926, DOI: 10.1016/j.dadr.2022.100032.Peer-Reviewed Original ResearchCocaine use disorderCocaine use outcomesOpioid useCognitive behavioral therapyContingency managementCocaine dependenceCognitive functionMethadone-maintained individualsUse outcomesEfficacy of modafinilSelf-reported abstinenceTreatment of CUDStimulant-like effectsPlatform treatmentPercentage of urinesPercent of daysDual opioidModafinil treatmentUse disordersPotential efficacyCocaine useModafinilPlaceboMinimal reportsBehavioral therapy
2019
Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promise
2018
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Carroll KM, Nich C, DeVito EE, Shi JM, Sofuoglu M. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal Of Clinical Psychiatry 2018, 79: 17m11669. PMID: 29286595, PMCID: PMC5866530, DOI: 10.4088/jcp.17m11669.Peer-Reviewed Original ResearchConceptsComputerized cognitive behavioral therapyStandard methadone treatmentCocaine use outcomesBenefits of galantamineMethadone treatmentCognitive behavioral therapyCognitive functionUse outcomesCommunity-based methadone maintenance programCocaine useStandard methadone maintenance treatmentBehavioral therapyUrine toxicology screenMethadone maintenance treatmentMethadone maintenance programCocaine treatment outcomesNicotinic acetylcholine receptorsCognitive functioningCocaine use disorderMethadone dosingSecondary outcomesToxicology screenMaintenance treatmentClinical trialsMedication administration
2016
Cognitive Function as a Transdiagnostic Treatment Target in Stimulant Use Disorders
Sofuoglu M, DeVito EE, Waters AJ, Carroll KM. Cognitive Function as a Transdiagnostic Treatment Target in Stimulant Use Disorders. Journal Of Dual Diagnosis 2016, 12: 90-106. PMID: 26828702, PMCID: PMC4837011, DOI: 10.1080/15504263.2016.1146383.Peer-Reviewed Original ResearchConceptsStimulant use disorderTransdiagnostic treatment targetExecutive controlAutomatic processCognitive impairmentUse disordersAddictive behaviorsCognitive functionDual-process modelCognitive behavioral therapyMaintenance of addictionCertain cognitive impairmentsPoor treatment retentionTreatment targetsAttentional biasApproach biasCognitive rehabilitationResponse inhibitionCognitive enhancementSustained attentionBehavioral therapyBehavioral treatmentAnxiety disordersBehavioral approachRates of lifetime
2015
Chapter 16 Perspectives on neurocognitive rehabilitation as an adjunct treatment for addictive disorders From cognitive improvement to relapse prevention
Rezapour T, DeVito EE, Sofuoglu M, Ekhtiari H. Chapter 16 Perspectives on neurocognitive rehabilitation as an adjunct treatment for addictive disorders From cognitive improvement to relapse prevention. Progress In Brain Research 2015, 224: 345-369. PMID: 26822366, DOI: 10.1016/bs.pbr.2015.07.022.Peer-Reviewed Original ResearchConceptsNeurocognitive rehabilitationNeurocognitive deficitsCognitive neuroscienceDrug addictionAddiction treatmentLong-term abstinenceExecutive controlCognitive rehabilitationSustained attentionFlexible delivery methodsCognitive improvementAddictive behaviorsCognitive functionAddiction medicineNeurocognitive functionAddictive disordersEarly abstinencePsychosocial therapySustained abstinenceAbstinenceAddictionNeuroscienceDeficitsTreatment adherenceDrug use
2012
Cognitive enhancement as a treatment for drug addictions
Sofuoglu M, DeVito EE, Waters AJ, Carroll KM. Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 2012, 64: 452-463. PMID: 22735770, PMCID: PMC3445733, DOI: 10.1016/j.neuropharm.2012.06.021.Peer-Reviewed Original ResearchConceptsCognitive enhancementBehavioral interventionsExecutive inhibitory controlCognitive impairmentDrug addictionSelective cognitive functionsCurrent illicit drug usersPoor treatment retentionCognitive enhancing agentsSignificant cognitive impairmentSpecific behavioral interventionsChronic drug useCognitive remediationInhibitory controlMarijuana addictionCognitive enhancersBehavioral treatmentCognitive functionDrug use behaviorsMultiple addictionsSubstance usersTreatment retentionInhibition functionFuture researchUse behaviors
2010
White Matter Integrity is Associated with Treatment Outcome Measures in Cocaine Dependence
Xu J, DeVito EE, Worhunsky PD, Carroll KM, Rounsaville BJ, Potenza MN. White Matter Integrity is Associated with Treatment Outcome Measures in Cocaine Dependence. Neuropsychopharmacology 2010, 35: 1541-1549. PMID: 20393459, PMCID: PMC2965037, DOI: 10.1038/npp.2010.25.Peer-Reviewed Original Research