2020
The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights
Sasaki CT, Doukas SG, Costa J, Vageli DP. The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights. Cancers 2020, 12: 1064. PMID: 32344873, PMCID: PMC7281001, DOI: 10.3390/cancers12051064.Peer-Reviewed Original ResearchAcidic bileUpper aerodigestive tractAdditional risk factorsBiomarkers of progressionSquamous cell carcinogenesisNF-κB activationNeck malignanciesAerodigestive tractInvasive cancerHistopathological changesRisk factorsHypopharyngeal mucosaEarly neoplasiaMalignant lesionsP53 expressionTranslational studiesVivo modelCell carcinogenesisBileExperimental modelEarly detectionCancerNovel evidenceMutagenic effectsFirst study
2019
Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cells
Doukas PG, Vageli DP, Doukas SG, Sasaki CT. Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cells. Oncotarget 2019, 10: 3339-3351. PMID: 31164956, PMCID: PMC6534360, DOI: 10.18632/oncotarget.26917.Peer-Reviewed Original ResearchAcidic bileNF-κB inhibitorBAY 11Hypopharyngeal cellsIL-6MiR-155MiR-375Specific NF-κB inhibitorMiR-21NF-κB inhibitionPre-neoplastic eventsEsophageal refluxLaryngopharyngeal cancerRisk factorsMolecular eventsEarly neoplasiaTherapeutic implicationsMiR-192MiR-451aClinical useWestern blotB activationBileOncogenic factorB inhibitor