2024
Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers
Carreiras M, Quiñones I, Chen H, Vázquez‐Araujo L, Small D, Frost R. Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers. Human Brain Mapping 2024, 45: e26564. PMID: 38339911, PMCID: PMC10823763, DOI: 10.1002/hbm.26564.Peer-Reviewed Original ResearchConceptsNeural circuitsFractional anisotropyRight superior longitudinal fasciculusSuperior longitudinal fasciculusRelevant sensory inputNeural network changesBrain responsesSemantic narrativesSemantic knowledgeMediation analysisPerceptual informationOlfactory circuitsLongitudinal fasciculusSensory processingChemosensory processingSensory neural circuitsVerbal descriptionsSemantic networkWine complexitySensory inputSemantic operationsWine tastingWine consumersTasting wineWine
2020
Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism 2020, 31: 493-502.e7. PMID: 32130881, PMCID: PMC7784207, DOI: 10.1016/j.cmet.2020.01.014.Peer-Reviewed Original ResearchConceptsGlucose metabolismPrevalence of obesityType 2 diabetesSugar-sweetened beveragesConsumption of sucraloseHealthy human participantsInsulin sensitivityTerm consumptionTaste perceptionMetabolismLong-term decreaseSweet tasteMetabolic sensitivityComorbiditiesGeneral consensusObesityDiabetesHuman participantsBeveragesMidbrainPrevalenceBrainSimilar relationship
2018
Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans
Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metabolism 2018, 29: 695-706.e4. PMID: 30595479, DOI: 10.1016/j.cmet.2018.12.006.Peer-Reviewed Original ResearchConceptsDopaminergic circuitsHigher cognitive centersSegregated brain regionsPeripheral physiological signalsPalatable food intakeReward valueDopamine releaseCognitive centersSubjective desireBrain regionsBrain areasUnderlying reinforcementFood intakeDorsal striatumRole of brainPhysiological signalsFood selection behaviorIntegrative pathwaysFMRIDesirePET methodBrainHumansIntakeSelection behavior
2015
What Can the Brain Teach Us about Winemaking? An fMRI Study of Alcohol Level Preferences
Frost R, Quiñones I, Veldhuizen M, Alava JI, Small D, Carreiras M. What Can the Brain Teach Us about Winemaking? An fMRI Study of Alcohol Level Preferences. PLOS ONE 2015, 10: e0119220. PMID: 25785844, PMCID: PMC4364721, DOI: 10.1371/journal.pone.0119220.Peer-Reviewed Original Research
2014
The neural signature of satiation is associated with ghrelin response and triglyceride metabolism
Sun X, Veldhuizen MG, Wray AE, de Araujo IE, Sherwin RS, Sinha R, Small DM. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiology & Behavior 2014, 136: 63-73. PMID: 24732416, PMCID: PMC4195817, DOI: 10.1016/j.physbeh.2014.04.017.Peer-Reviewed Original ResearchConceptsPalatable foodMeal terminationBrain responsesAd libitum mealPost-prandial reductionMedial orbitofrontal cortexDorsolateral prefrontal cortexGhrelin responseAcute changesFree fatty acidsPeripheral signalsTriglyceride metabolismBrain regionsBrain circuitsOrbitofrontal cortexPrefrontal cortexAmount of foodGhrelinMidbrainMilkshakeTriglyceridesCortexFatty acidsEnergy storesGreater attenuation
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluationVentromedial Prefrontal Cortex Response to Concentrated Sucrose Reflects Liking Rather Than Sweet Quality Coding
Rudenga KJ, Small DM. Ventromedial Prefrontal Cortex Response to Concentrated Sucrose Reflects Liking Rather Than Sweet Quality Coding. Chemical Senses 2013, 38: 585-594. PMID: 23828907, PMCID: PMC3747761, DOI: 10.1093/chemse/bjt029.Peer-Reviewed Original ResearchDecreased caudate response to milkshake is associated with higher body mass index and greater impulsivity
Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior 2013, 121: 103-111. PMID: 23562867, PMCID: PMC3731396, DOI: 10.1016/j.physbeh.2013.03.025.Peer-Reviewed Original ResearchConceptsBody mass indexCaudate responseMass indexCaudate nucleusBrain responsesHigher body mass indexWeight gainHealthy weight subjectsTasteless control solutionEnergy-dense foodsSelf-reported impulsivityWeight subjectsNegative associationVentral putamenDorsal striatumFood rewardDense foodsSignificant associationInverse correlationMilkshakeOverweightGreater impulsivityMeasures of impulsivityGreater responseAssociationA question of taste
Murdoch S, Gorrie G, Small DM, Bhattacharya JJ. A question of taste. Neurology 2013, 80: 1265. PMID: 23530152, PMCID: PMC3691783, DOI: 10.1212/wnl.0b013e318289dcd9.Peer-Reviewed Original Research
2012
Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Nolan-Poupart S, Veldhuizen MG, Geha P, Small DM. Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger. Appetite 2012, 60: 168-174. PMID: 23064394, PMCID: PMC3526000, DOI: 10.1016/j.appet.2012.09.032.Peer-Reviewed Original ResearchConceptsAbsence of hungerFunctional magnetic resonance imagingSubsequent intakeRatings of hungerPeriaqueductal gray regionMidbrain responsesMagnetic resonance imagingKey reward regionsPalatable milkshakeSignificant positive associationPalatable foodResonance imagingInsular responsesOrbitofrontal cortexNeural circuitsGreater intakeMilkshake consumptionIntakeReward regionsBrain responsesEnhanced responseMilkshakePositive associationMidbrainGray region
2011
The Anterior Insular Cortex Represents Breaches of Taste Identity Expectation
Veldhuizen MG, Douglas D, Aschenbrenner K, Gitelman DR, Small DM. The Anterior Insular Cortex Represents Breaches of Taste Identity Expectation. Journal Of Neuroscience 2011, 31: 14735-14744. PMID: 21994389, PMCID: PMC3221736, DOI: 10.1523/jneurosci.1502-11.2011.Peer-Reviewed Original ResearchModality-Specific Neural Effects of Selective Attention to Taste and Odor
Veldhuizen MG, Small DM. Modality-Specific Neural Effects of Selective Attention to Taste and Odor. Chemical Senses 2011, 36: 747-760. PMID: 21685407, PMCID: PMC3175104, DOI: 10.1093/chemse/bjr043.Peer-Reviewed Original ResearchConceptsPrimary olfactory cortexPrimary taste cortexAnterior insular cortexInsular cortexOlfactory cortexTaste cortexPrimary gustatory cortexFunctional magnetic resonancePrimary olfactoryGustatory cortexModality-specific activationInsular responsesNeural effectsCortexBrain responsesMultimodal regionsTaste perceptionMagnetic resonanceGeneral effectSelective attentionActivationResponse
2010
Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula
Rudenga K, Green B, Nachtigal D, Small DM. Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula. Chemical Senses 2010, 35: 693-703. PMID: 20595201, PMCID: PMC2943409, DOI: 10.1093/chemse/bjq068.Peer-Reviewed Original ResearchConceptsAnterior ventral insulaVentral insulaOral stimulationTasteless control solutionFunctional magnetic resonanceVentral pallidumPhysiological significanceHarmful stimuliInsular responsesInsulaOral sensationNutritive stimulusModalitiesDifferential connectivityPresent studyStimulationMagnetic resonanceSensory modalitiesSubjectsHypothalamusStimuliStriatumPallidumTaste representation in the human insula
Small DM. Taste representation in the human insula. Brain Structure And Function 2010, 214: 551-561. PMID: 20512366, DOI: 10.1007/s00429-010-0266-9.Peer-Reviewed Original ResearchConceptsInsular cortexTaste cortexTaste representationsUnimodal sensory corticesPrimary taste cortexHuman insular cortexAnterior insular cortexHuman insulaInterspecies differencesSensory cortexSense of tasteCortexFeeding behaviorSensory regionsSignificant interspecies differencesCritical relayPrimary aimMonkeysHumansGenetically Determined Differences in Brain Response to a Primary Food Reward
Felsted JA, Ren X, Chouinard-Decorte F, Small DM. Genetically Determined Differences in Brain Response to a Primary Food Reward. Journal Of Neuroscience 2010, 30: 2428-2432. PMID: 20164326, PMCID: PMC2831082, DOI: 10.1523/jneurosci.5483-09.2010.Peer-Reviewed Original ResearchConceptsBrain responsesPrimary food rewardFunctional magnetic resonanceTaqIA A1 alleleOrbital frontal cortexReward driveIndividual differencesNeural responsesFuture weight gainFood rewardPalatable foodNeuroimaging techniquesPerceptual responsesBiological underpinningsIndividual factorsFrontal cortexImpulsivityDiminished dopamineSimilar ratingsFood reinforcementRewardSpecific associationNeurophysiologyMilkshakeBody mass index
2009
Neural correlates of evaluative compared with passive tasting
Bender G, Veldhuizen MG, Meltzer JA, Gitelman DR, Small DM. Neural correlates of evaluative compared with passive tasting. European Journal Of Neuroscience 2009, 30: 327-338. PMID: 19614981, PMCID: PMC2776645, DOI: 10.1111/j.1460-9568.2009.06819.x.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexOrbitofrontal cortexPrimary taste cortexLeft lateral orbitofrontal cortexFunctional magnetic resonanceTasteless solutionMaximal responseTaste cortexFunction of taskCortical representationGustatory informationAnterior insulaVentral regionNeural responsesPreferential connectivityAmygdalaNeural correlatesCortexInsulaNeural encodingSubjectsStimulus presenceMagnetic resonanceResponseEarly relaySymposium Overview
Small DM, Scott TR. Symposium Overview. Annals Of The New York Academy Of Sciences 2009, 1170: 343-346. PMID: 19686158, PMCID: PMC2729766, DOI: 10.1111/j.1749-6632.2009.03918.x.Peer-Reviewed Original ResearchThe Role of the Parabrachial Nucleus in Taste Processing and Feeding
Scott TR, Small DM. The Role of the Parabrachial Nucleus in Taste Processing and Feeding. Annals Of The New York Academy Of Sciences 2009, 1170: 372-377. PMID: 19686161, DOI: 10.1111/j.1749-6632.2009.03906.x.Peer-Reviewed Original ResearchConceptsParabrachial nucleusVentral forebrainIntegration of tasteSolitary tractForebrain projectionsVisceral sensationOrbitofrontal cortexFeeding behaviorTaste processingHedonic assessmentRodentsCortexForebrainSensory informationActivity parallelPrimatesFood selectionTaste activityNTSEarly recordingsFeedingThalamusReflexSubnucleiHedonic information
2008
Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study
Stice E, Spoor S, Bohon C, Veldhuizen MG, Small DM. Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study. Journal Of Psychopathology And Clinical Science 2008, 117: 924-935. PMID: 19025237, PMCID: PMC2681092, DOI: 10.1037/a0013600.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAdolescent girlsGreater activationFunctional magnetic resonance imaging studySomatosensory regionsRelation of rewardGustatory cortexDopamine receptor availabilityMagnetic resonance imaging studyResonance imaging studyChocolate milkshakeTasteless solutionConsequent weight gainFood intakeBrain regionsGreater rewardsHedonic aspectsDecreased activationWeak activationRewardReceptor availabilityMilkshakeGirlsImaging studiesMagnetic resonance imagingSeparable Substrates for Anticipatory and Consummatory Food Chemosensation
Small DM, Veldhuizen MG, Felsted J, Mak YE, McGlone F. Separable Substrates for Anticipatory and Consummatory Food Chemosensation. Neuron 2008, 57: 786-797. PMID: 18341997, PMCID: PMC2669434, DOI: 10.1016/j.neuron.2008.01.021.Peer-Reviewed Original Research