2021
Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity
Perszyk EE, Hutelin Z, Trinh J, Kanyamibwa A, Fromm S, Davis XS, Wall KM, Flack KD, DiFeliceantonio AG, Small DM. Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity. Nutrients 2021, 13: 1203. PMID: 33917347, PMCID: PMC8067354, DOI: 10.3390/nu13041203.Peer-Reviewed Original Research
2020
Development of MacroPics: A novel food picture set to dissociate the effects of carbohydrate and fat on eating behaviors
Fromm S, Perszyk EE, Kanyamibwa A, Wall KM, Hutelin Z, Trinh J, Davis XS, Green BG, Flack KD, DiFeliceantonio A, Small DM. Development of MacroPics: A novel food picture set to dissociate the effects of carbohydrate and fat on eating behaviors. Appetite 2020, 159: 105051. PMID: 33242580, DOI: 10.1016/j.appet.2020.105051.Peer-Reviewed Original Research
2015
Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility
Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM. Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility. Journal Of Neuroscience 2015, 35: 7964-7976. PMID: 25995480, PMCID: PMC4438134, DOI: 10.1523/jneurosci.3884-14.2015.Peer-Reviewed Original ResearchConceptsAbsence of hungerWeight changeBasolateral amygdalaLong-term weight changeLong-term weight gainWeight gain susceptibilityGustatory inputD2 receptor densityA1 allele carriersAmygdala responseSated subjectsGhrelin levelsInitial BMILateral hypothalamusHuman hypothalamusAllele carriersReceptor densityAmygdala pathwayHealthy individualsElicit eatingDopamine signalingConfer susceptibilityWeight gainDynamic causal modelingNonhomeostatic eating
2014
The neural signature of satiation is associated with ghrelin response and triglyceride metabolism
Sun X, Veldhuizen MG, Wray AE, de Araujo IE, Sherwin RS, Sinha R, Small DM. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiology & Behavior 2014, 136: 63-73. PMID: 24732416, PMCID: PMC4195817, DOI: 10.1016/j.physbeh.2014.04.017.Peer-Reviewed Original ResearchConceptsPalatable foodMeal terminationBrain responsesAd libitum mealPost-prandial reductionMedial orbitofrontal cortexDorsolateral prefrontal cortexGhrelin responseAcute changesFree fatty acidsPeripheral signalsTriglyceride metabolismBrain regionsBrain circuitsOrbitofrontal cortexPrefrontal cortexAmount of foodGhrelinMidbrainMilkshakeTriglyceridesCortexFatty acidsEnergy storesGreater attenuation
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluation
2009
Individual differences in the neurophysiology of reward and the obesity epidemic
Small DM. Individual differences in the neurophysiology of reward and the obesity epidemic. International Journal Of Obesity 2009, 33: s44-s48. PMID: 19528979, PMCID: PMC2788336, DOI: 10.1038/ijo.2009.71.Peer-Reviewed Original Research