2022
Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression
Kroemer NB, Opel N, Teckentrup V, Li M, Grotegerd D, Meinert S, Lemke H, Kircher T, Nenadić I, Krug A, Jansen A, Sommer J, Steinsträter O, Small DM, Dannlowski U, Walter M. Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression. JAMA Psychiatry 2022, 79: 993-1003. PMID: 36001327, PMCID: PMC9403857, DOI: 10.1001/jamapsychiatry.2022.2464.Peer-Reviewed Original ResearchConceptsMajor depressive disorderNAcc functional connectivityFunctional connectivityBody weightNucleus accumbensTreatment of MDDResting-state functional connectivityCase-control studySymptom-specific associationsHealthy control participantsIdentification of biomarkersClassification of diagnosesCohort studyMost patientsMean ageDepressive episodeDepressive disorderReduced appetiteMagnetic resonance imaging dataMAIN OUTCOMESubstantial burdenDepressive symptomsPatientsVentromedial prefrontal cortexReward circuitChronic pain precedes disrupted eating behavior in low-back pain patients
Lin Y, De Araujo I, Stanley G, Small D, Geha P. Chronic pain precedes disrupted eating behavior in low-back pain patients. PLOS ONE 2022, 17: e0263527. PMID: 35143525, PMCID: PMC8830732, DOI: 10.1371/journal.pone.0263527.Peer-Reviewed Original ResearchConceptsLow back pain patientsChronic low back pain patientsFat-rich foodsPain patientsChronic painCLBP patientsSBP patientsNucleus accumbensBack pain patientsChronic pain patientsHealthy control subjectsNucleus accumbens volumePain chronificationFat ingestionHedonic feedingPatient populationAccumbens volumeControl subjectsLimbic brainPainEarly coursePatientsBehavioral alterationsHedonic perceptionNeurological standpoint
2020
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2016
Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. PMID: 27303627, PMCID: PMC4897751, DOI: 10.12688/f1000research.8300.2.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaPatientsDigestiveImpairmentComplex mechanisms“White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel L, Arvanitakis Z, Gandy S, Small D, Kahn C, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. “White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. DOI: 10.12688/f1000research.8300.1.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaMeeting summaryPatientsDigestiveImpairmentComplex mechanisms
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluation
2005
Increased taste intensity perception exhibited by patients with chronic back pain
Small DM, Apkarian A. Increased taste intensity perception exhibited by patients with chronic back pain. Pain 2005, 120: 124-130. PMID: 16360267, DOI: 10.1016/j.pain.2005.10.021.Peer-Reviewed Original ResearchConceptsChronic back painCBP patientsBack painControl subjectsSpecific brain sitesSpecific brain abnormalitiesSuprathreshold taste intensityCortical injuryTaste disturbanceBrain atrophyTaste intensity perceptionPain perceptionBrain abnormalitiesBrain sitesPainBrain regionsSense of tastePatientsGustatory stimuliBitter stimuliRecognition thresholdSubjectsVisual assessmentFurther evidenceSpecific patternsGustatory agnosia
Small DM, Bernasconi N, Bernasconi A, Sziklas V, Jones-Gotman M. Gustatory agnosia. Neurology 2005, 64: 311-317. PMID: 15668430, DOI: 10.1212/01.wnl.0000149515.77718.35.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgnosiaAmygdalaAnorexiaAtrophyCerebral CortexElectrodes, ImplantedElectroencephalographyEpilepsy, Temporal LobeFemaleFollow-Up StudiesFood PreferencesHippocampusHumansMagnetic Resonance ImagingMeningoencephalitisNeuropsychological TestsOlfaction DisordersPositron-Emission TomographyPostoperative ComplicationsTasteTaste ThresholdTemporal LobeConceptsMedial temporal lobeTemporal lobeSurgical treatmentLeft medial temporal lobeAnteromedial temporal lobeFunctional neuroimaging studiesBilateral atrophyIntractable epilepsyComplete atrophyPreoperative MRIGustatory functionLeft amygdalaLeft insulaChemosensory evaluationNeuroimaging studiesTaste abilityPatientsAtrophyAmygdalaAversive tasteLobeRecognition thresholdAgnosiaTreatmentTaste quality
2001
Changes in Taste Intensity Perception Following Anterior Temporal Lobe Removal in Humans
Small D, Zatorre R, Jones-Gotman M. Changes in Taste Intensity Perception Following Anterior Temporal Lobe Removal in Humans. Chemical Senses 2001, 26: 425-432. PMID: 11369677, DOI: 10.1093/chemse/26.4.425.Peer-Reviewed Original ResearchConceptsAnterior temporal lobeTemporal lobeHealthy control subjectsTemporal lobe removalsRight anterior temporal lobeRight temporal groupPatient groupIntractable epilepsyControl subjectsControl groupMeasures ANOVAMeasures analysisBitter tasteSignificant differencesUnpleasant bitter tasteStimulus concentrationLobeTaste perceptionSubjectsGroupTemporal groupsPatientsIntensity perceptionEpilepsy
1997
A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition
Small D, Jones-Gotman M, Zatorre R, Petrides M, Evans A. A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition. Journal Of Neuroscience 1997, 17: 5136-5142. PMID: 9185551, PMCID: PMC6573307, DOI: 10.1523/jneurosci.17-13-05136.1997.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowAnteromedial temporal lobeGroup of patientsTemporal lobeRight anterior temporal lobectomyOrbitofrontal cortexCaudolateral orbitofrontal cortexAnterior temporal lobectomyCerebral blood flowRight anterior temporal lobePrimary taste cortexTreatment of epilepsyPositron emission tomographyRight cerebral hemisphereAnterior temporal lobeRCBF increasesTemporal lobectomyGustatory functionTaste cortexBlood flowCerebral hemispheresControl groupEmission tomographyPatientsTaste sensation