2021
Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity
Perszyk EE, Hutelin Z, Trinh J, Kanyamibwa A, Fromm S, Davis XS, Wall KM, Flack KD, DiFeliceantonio AG, Small DM. Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity. Nutrients 2021, 13: 1203. PMID: 33917347, PMCID: PMC8067354, DOI: 10.3390/nu13041203.Peer-Reviewed Original Research
2015
Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum
Cosgrove KP, Veldhuizen MG, Sandiego CM, Morris ED, Small DM. Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum. Synapse 2015, 69: 195-202. PMID: 25664726, PMCID: PMC4411955, DOI: 10.1002/syn.21809.Peer-Reviewed Original ResearchConceptsBody mass indexPalatable food consumptionDorsal striatumMass indexBOLD responseReceptor availabilityRelationship of BMIFood consumptionPET studiesMagnetic resonance imaging studyPositron emission tomography studyBlood oxygen level-dependent (BOLD) responseDopamine D2/3 receptorsHigh-fat dietDopamine receptor levelsEmission tomography studiesFMRI studyResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent responsesReliable inverse relationshipHealthy weightD2/3 receptorsStriatal circuitryFat diet
2014
Working memory and reward association learning impairments in obesity
Coppin G, Nolan-Poupart S, Jones-Gotman M, Small DM. Working memory and reward association learning impairments in obesity. Neuropsychologia 2014, 65: 146-155. PMID: 25447070, PMCID: PMC4259845, DOI: 10.1016/j.neuropsychologia.2014.10.004.Peer-Reviewed Original ResearchConceptsHealthy weight individualsNegative outcomesExplicit learningReward association learningProbabilistic learning taskFunction of groupHealthy weight groupObese individualsReward associationsStimulus-rewardExecutive functionAssociation learningLearning taskExperiment 1Learning impairmentHealthy weightParadoxical preferenceWeight individualsPositive outcomesMemoryWeight groupInfluence of obesitySecond experimentCurrent studyDeficits