2021
Post-traumatic olfactory loss and brain response beyond olfactory cortex
Pellegrino R, Farruggia MC, Small DM, Veldhuizen MG. Post-traumatic olfactory loss and brain response beyond olfactory cortex. Scientific Reports 2021, 11: 4043. PMID: 33597627, PMCID: PMC7889874, DOI: 10.1038/s41598-021-83621-2.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexOlfactory impairmentOlfactory cortexFunctional anosmiaPost-traumatic olfactory lossPrimary olfactory areasWhole-brain responsesBrain responsesGray matter densityHigher-order areasOlfactory lossPiriform cortexHead traumaHealthy controlsOlfactory areasOdorless stimuliOlfactory functionMediodorsal thalamusCortical areasVentromedial prefrontal cortexCingulate cortexFrontal operculumCortexAnterior insulaPrefrontal cortex
2012
An fMRI Study of the Interactions Between the Attention and the Gustatory Networks
Veldhuizen MG, Gitelman DR, Small DM. An fMRI Study of the Interactions Between the Attention and the Gustatory Networks. Chemosensory Perception 2012, 5: 117-127. PMID: 25419265, PMCID: PMC4239214, DOI: 10.1007/s12078-012-9122-z.Peer-Reviewed Original ResearchAnterior cingulate cortexFrontal eye fieldCingulate cortexPosterior parietal cortexGustatory cortexEye fieldParietal operculumParietal cortexFrontal operculumAnterior insulaRight anterior insulaPsychophysiological interaction analysisCortexDynamic causal modelingCortex actsIndirect modulationFMRI studyBrain responsesInsulaGoal-directed behaviorIncoming sensory signalsConnectivity analysisSensory signalsCurrent studyAttention task
2011
Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food
Stice E, Yokum S, Burger KS, Epstein LH, Small DM. Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food. Journal Of Neuroscience 2011, 31: 4360-4366. PMID: 21430137, PMCID: PMC3260083, DOI: 10.1523/jneurosci.6604-10.2011.Peer-Reviewed Original ResearchConceptsNormal weight humansObese humansStriatal responsesFood intakeOrbitofrontal cortexDopamine signalingWeight gainInitial vulnerability factorsGenetic riskStriatal D2 receptorsMonetary rewardsNormal-weight adolescentsPalatable food intakeD2 receptor densityD2 receptorsHigh-risk youthParietal operculumReceptor densitySomatosensory regionsPalatable foodFoods contributesFrontal operculumReward circuitryReduced dopamineObesity
2005
Odor/taste integration and the perception of flavor
Small DM, Prescott J. Odor/taste integration and the perception of flavor. Experimental Brain Research 2005, 166: 345-357. PMID: 16028032, DOI: 10.1007/s00221-005-2376-9.Peer-Reviewed Original ResearchConceptsFlavor perceptionUnitary perceptionCross-modal sensory interactionsSensory inputVentral lateral prefrontal cortexParticular sensory characteristicsLateral prefrontal cortexPosterior parietal cortexMultiple sensory inputsAnterior cingulate cortexPerception of flavorAttentional allocationHeteromodal regionsNeural processesAnterior insulaFlavor processingFrontal operculumOrbitofrontal cortexPrefrontal cortexCingulate cortexFlavor of foodParietal cortexNeurophysiological studiesPerceptionSensory interaction
2004
Experience-Dependent Neural Integration of Taste and Smell in the Human Brain
Small DM, Voss J, Mak YE, Simmons KB, Parrish T, Gitelman D. Experience-Dependent Neural Integration of Taste and Smell in the Human Brain. Journal Of Neurophysiology 2004, 92: 1892-1903. PMID: 15102894, DOI: 10.1152/jn.00050.2004.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexPosterior parietal cortexOrbitofrontal cortexCaudal orbitofrontal cortexFrontal operculumPrefrontal cortexParietal cortexFlavor perceptionVentral lateral prefrontal cortexVentral insulaEvent-related fMRIVentrolateral prefrontal cortexLateral prefrontal cortexDistinct sensory inputsAnterior ventral insulaPerception of flavorUnimodal stimuliSuperadditive responsesNeural correlatesBrain responsesNeural responsesFlavor processingNeural suppressionOlfactory deliveryDorsal insula
1999
Human cortical gustatory areas
Small D, Zald D, Jones-Gotman M, Zatorre R, Pardo J, Frey S, Petrides M. Human cortical gustatory areas. Neuroreport 1999, 10: 7-13. PMID: 10094124, DOI: 10.1097/00001756-199901180-00002.Peer-Reviewed Original Research