2020
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunction
2018
Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia
Espeland M, Small D, Stoeckel L. Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia. 2018, 117-141. DOI: 10.1016/b978-0-12-809454-9.00007-x.Peer-Reviewed Original ResearchRisk factorsMetabolic dysfunctionModifiable risk factorsDevelopment of dementiaComplex multifactorial interactionPhysical inactivityCognitive dysfunctionNeurocognitive dysfunctionPhysical activityNeurocognitive impairmentObesityDysfunctionDiabetesDementiaMultifactorial interactionsDietFactorsImpairment
2017
DRD2: Bridging the Genome and Ingestive Behavior
Sun X, Luquet S, Small DM. DRD2: Bridging the Genome and Ingestive Behavior. Trends In Cognitive Sciences 2017, 21: 372-384. PMID: 28372879, PMCID: PMC5745142, DOI: 10.1016/j.tics.2017.03.004.Peer-Reviewed Original ResearchConceptsGenetic variantsCommon gene variantsMetabolic dysfunctionNeurocognitive impairmentAppetitive functionsDA signalingCognitive declinePolygenic obesityBrain structures× environment interactionGene variantsConfer riskIngestive behaviorGene × environment interactionsNeurotransmitter dopamineObesityCognitive changesDopamineMetabolic signalsEnvironment interactionPivotal roleRiskSignalingFeedingDysfunctionDopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective
Small DM. Dopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective. Frontiers In Neuroscience 2017, 11: 134. PMID: 28400713, PMCID: PMC5368264, DOI: 10.3389/fnins.2017.00134.Peer-Reviewed Original Research
2016
Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. PMID: 27303627, PMCID: PMC4897751, DOI: 10.12688/f1000research.8300.2.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaPatientsDigestiveImpairmentComplex mechanisms“White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel L, Arvanitakis Z, Gandy S, Small D, Kahn C, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. “White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. DOI: 10.12688/f1000research.8300.1.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaMeeting summaryPatientsDigestiveImpairmentComplex mechanisms