2018
Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans
Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metabolism 2018, 29: 695-706.e4. PMID: 30595479, DOI: 10.1016/j.cmet.2018.12.006.Peer-Reviewed Original ResearchConceptsDopaminergic circuitsHigher cognitive centersSegregated brain regionsPeripheral physiological signalsPalatable food intakeReward valueDopamine releaseCognitive centersSubjective desireBrain regionsBrain areasUnderlying reinforcementFood intakeDorsal striatumRole of brainPhysiological signalsFood selection behaviorIntegrative pathwaysFMRIDesirePET methodBrainHumansIntakeSelection behavior
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
2014
The neural signature of satiation is associated with ghrelin response and triglyceride metabolism
Sun X, Veldhuizen MG, Wray AE, de Araujo IE, Sherwin RS, Sinha R, Small DM. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiology & Behavior 2014, 136: 63-73. PMID: 24732416, PMCID: PMC4195817, DOI: 10.1016/j.physbeh.2014.04.017.Peer-Reviewed Original ResearchConceptsPalatable foodMeal terminationBrain responsesAd libitum mealPost-prandial reductionMedial orbitofrontal cortexDorsolateral prefrontal cortexGhrelin responseAcute changesFree fatty acidsPeripheral signalsTriglyceride metabolismBrain regionsBrain circuitsOrbitofrontal cortexPrefrontal cortexAmount of foodGhrelinMidbrainMilkshakeTriglyceridesCortexFatty acidsEnergy storesGreater attenuation
2013
Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions
2012
Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies
Tang D, Fellows L, Small D, Dagher A. Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies. Physiology & Behavior 2012, 106: 317-324. PMID: 22450260, DOI: 10.1016/j.physbeh.2012.03.009.Peer-Reviewed Original ResearchConceptsSmoking cuesOrbital frontal cortexNeutral cuesFood cuesVisual foodBlood oxygen level-dependent (BOLD) responseBrain regionsSimilar brain regionsBilateral orbital frontal cortexActivation likelihood estimationFrontal cortexFunctional MRI studyLevel-dependent responsesBrain imaging studiesNeuro-imaging studiesDrug cuesImaging studiesInsula activationSubjective cravingConditioned cuesIncentive salienceBrain responsesBilateral insulaBrain networksLeft amygdala
2008
Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study
Stice E, Spoor S, Bohon C, Veldhuizen MG, Small DM. Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study. Journal Of Psychopathology And Clinical Science 2008, 117: 924-935. PMID: 19025237, PMCID: PMC2681092, DOI: 10.1037/a0013600.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAdolescent girlsGreater activationFunctional magnetic resonance imaging studySomatosensory regionsRelation of rewardGustatory cortexDopamine receptor availabilityMagnetic resonance imaging studyResonance imaging studyChocolate milkshakeTasteless solutionConsequent weight gainFood intakeBrain regionsGreater rewardsHedonic aspectsDecreased activationWeak activationRewardReceptor availabilityMilkshakeGirlsImaging studiesMagnetic resonance imaging
2005
Increased taste intensity perception exhibited by patients with chronic back pain
Small DM, Apkarian A. Increased taste intensity perception exhibited by patients with chronic back pain. Pain 2005, 120: 124-130. PMID: 16360267, DOI: 10.1016/j.pain.2005.10.021.Peer-Reviewed Original ResearchConceptsChronic back painCBP patientsBack painControl subjectsSpecific brain sitesSpecific brain abnormalitiesSuprathreshold taste intensityCortical injuryTaste disturbanceBrain atrophyTaste intensity perceptionPain perceptionBrain abnormalitiesBrain sitesPainBrain regionsSense of tastePatientsGustatory stimuliBitter stimuliRecognition thresholdSubjectsVisual assessmentFurther evidenceSpecific patterns
2003
The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention
Small DM, Gitelman DR, Gregory MD, Nobre AC, Parrish TB, Mesulam M. The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention. NeuroImage 2003, 18: 633-641. PMID: 12667840, DOI: 10.1016/s1053-8119(02)00012-5.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCue benefitPrefrontal cortexPosterior cingulateAttention-related areasNeutral cuesCentral cuesSpatial attentionSpatial expectancyFMRI scanningIrrelevant locationsMotivational valenceGreater activationParietal cortexBrain regionsCuesPeripheral targetsReaction timeCingulateCortexDistractibilityExpectancySignificant eventsAttentionValence
2002
Toward an Understanding of the Brain Substrates of Reward in Humans
Small DM. Toward an Understanding of the Brain Substrates of Reward in Humans. Neuron 2002, 33: 668-671. PMID: 11879644, DOI: 10.1016/s0896-6273(02)00620-7.Peer-Reviewed Original Research
2001
Changes in brain activity related to eating chocolate
Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M. Changes in brain activity related to eating chocolate. Brain 2001, 124: 1720-1733. PMID: 11522575, DOI: 10.1093/brain/124.9.1720.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowOnly brain regionBrain activityPosterior cingulate cortexNon-specific effectsChemosensory areasBlood flowPET scansCingulate cortexBrain regionsPatterns of activitySensory stimuliFunctional segregationSatietyPiece of chocolateSubjectsReward valueSubjects' ratingsNeural representationSeparate motivational systemsActivityCaudomedialCortex