NOD2 Regulates CXCR3-Dependent CD8+ T Cell Accumulation in Intestinal Tissues with Acute Injury
Wu X, Lahiri A, Haines GK, Flavell RA, Abraham C. NOD2 Regulates CXCR3-Dependent CD8+ T Cell Accumulation in Intestinal Tissues with Acute Injury. The Journal Of Immunology 2014, 192: 3409-3418. PMID: 24591373, PMCID: PMC4064676, DOI: 10.4049/jimmunol.1302436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBone Marrow CellsCD3 ComplexCD8-Positive T-LymphocytesCell MovementCells, CulturedChemokine CXCL10Chemokine CXCL9ColitisDendritic CellsFlow CytometryGene ExpressionInterferon-gammaInterleukin-10Intestinal MucosaIntestinesMacrophagesMiceMice, Inbred C57BLMice, KnockoutModels, ImmunologicalNod2 Signaling Adaptor ProteinReceptors, CXCR3Reverse Transcriptase Polymerase Chain ReactionConceptsT cell accumulationT cell migrationT cell activationT cellsIntestinal injuryIntestinal tissueCell accumulationCell activationSmall intestinal lamina propriaIFN-γ neutralizationIntestinal T cellsT-cell depletionIntestinal immune homeostasisIL-10 productionT cell recruitmentHuman autoimmune diseasesIntestinal lamina propriaTreatment of miceIL-10 expressionIntestinal stromal cellsT cell outcomesCell migrationCXCR3 blockadeMAb administrationDendritic cells