2023
1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity
CHUNG T, DEAJON-JACKSON J, BINI J, SONG H, SANCHEZ RANGEL E, YECKEL C, HWANG J, STACHENFELD N, BELFORT-DEAGUIAR R. 1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity. Diabetes 2023, 72 DOI: 10.2337/db23-1541-p.Peer-Reviewed Original ResearchSympathetic nervous system activityMuscle sympathetic nerve activityMixed meal testNormal weightNervous system activityDistribution volume ratioPET-CTHeart rateSympathetic nerve activitySystem activityIngestion of foodMSNA increasesEndogenous NEMeal testNE releaseNerve activityOB subjectsObesity altersKidney diseaseDeltoid muscleLean individualsOB individualsNE transporterObeseFood ingestion
2018
Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes
ELSHAFIE A, LAM W, PARIKH L, RANGEL E, SCHMIDT C, HWANG J, YECKEL C, SHERWIN R, BELFORT-DEAGUIAR R. Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes. Diabetes 2018, 67 DOI: 10.2337/db18-82-lb.Peer-Reviewed Original ResearchGlucose infusion rateInsulin secretion-sensitivity index-2Beta-cell functionContinuous overlapping net glycemic actionGlucose variabilityContinuous glucose monitorT2D subjectsObese subjectsInsulin levelsGV indicesGlucose metabolismCell functionInsulin sensitivity indexType 2 diabetesGlycemic Risk AssessmentCGM indicesHealthy obesityMannKind CorporationHealthy obeseOB subjectsGlycemic excursionsInsulin resistanceIncremental AUCGlycemic variabilityRegeneron Pharmaceuticals
2013
Blood pressure hyperreactivity
Kunrath J, Gurzau E, Gurzau A, Goessler W, Gelmann ER, Thach TT, McCarty KM, Yeckel CW. Blood pressure hyperreactivity. Journal Of Hypertension 2013, 31: 361-369. PMID: 23203141, PMCID: PMC3542419, DOI: 10.1097/hjh.0b013e32835c175f.Peer-Reviewed Original ResearchConceptsBlood pressure hyperreactivityBlood pressure recoveryHypertensive responseUnexposed groupMiddle-aged menCold pressor testInorganic arsenic exposureInorganic arsenicCardiovascular stress reactivityNormotensive menBlood pressureEssential hypertensionHypertension riskPressor testHyperreactivityChronic exposureArsenic exposureArsenic-endemic regionEarly signsStress-induced changesFunctional evaluationUrine samplesDrinking waterStress reactivityGreater probability
2012
Ex Vivo and In Vivo Evaluation of the Norepinephrine Transporter Ligand [11C]MRB for Brown Adipose Tissue Imaging
Lin SF, Fan X, Yeckel CW, Weinzimmer D, Mulnix T, Gallezot JD, Carson RE, Sherwin RS, Ding YS. Ex Vivo and In Vivo Evaluation of the Norepinephrine Transporter Ligand [11C]MRB for Brown Adipose Tissue Imaging. Nuclear Medicine And Biology 2012, 39: 1081-1086. PMID: 22595487, PMCID: PMC4067762, DOI: 10.1016/j.nucmedbio.2012.04.005.Peer-Reviewed Original Research
2011
Skeletal Muscle Nonnutritive Blood Flow Increases in Response to a Sit‐to‐Stand Orthostatic Challenge
Yeckel C, Castillo M, Gosselin M, Gulanski B. Skeletal Muscle Nonnutritive Blood Flow Increases in Response to a Sit‐to‐Stand Orthostatic Challenge. The FASEB Journal 2011, 25: 814.12-814.12. DOI: 10.1096/fasebj.25.1_supplement.814.12.Peer-Reviewed Original ResearchMuscle blood flowBlood flowOrthostatic challengeVenous occlusionInitial hemodynamic responseMuscle contraction conditionsBlood flow increasesMuscle oxygen consumptionOxygen consumption responsesYoung healthy participantsVenous returnMuscle totalHemodynamic responseCalf musclesHealthy participantsOxygen consumptionOcclusionRight posturePhysiological challengesFlow increasesContraction controlResponseControlBloodContraction conditions
2009
Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women
DiPietro L, Dziura J, Yeckel CW. Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women. Diabetes Care 2009, 33: 165-167. PMID: 19808930, PMCID: PMC2797964, DOI: 10.2337/dc09-1365.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceOral glucose tolerance testAbdominal obesityGlucose tolerance testHealthy older womenInsulin resistanceOlder womenTolerance testLow-dose insulin infusionHepatic glucose productionGlucose excursionsInsulin infusionPlasma glucoseAbdominal circumferenceInsulin concentrationsInsulin suppressionMin postchallengeObesityGlycemic responseClamp techniqueGlucose productionWomenHyperglycemiaProduction suppressionPostchallenge
2007
Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older Women
DiPietro L, Yeckel C, Dziura J. Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older Women. Medicine & Science In Sports & Exercise 2007, 39: s288. DOI: 10.1249/01.mss.0000274112.76453.98.Peer-Reviewed Original ResearchMaximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance
Yeckel C, Gulanski B, Lopes M, Dziura J, Parish R, Sherwin R. Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance. The FASEB Journal 2007, 21: a575-a575. DOI: 10.1096/fasebj.21.5.a575.Peer-Reviewed Original ResearchSympathetic overactivityInsulin resistanceHeart rateWhole-body insulin sensitivity indexExercise heart rate recoveryHealthy young cohortMaximal fitness testInsulin sensitivity indexHeart rate recoveryAutonomic nervous systemInsulin sensitivity measurementsRecovery heart rateParasympathetic dysfunctionSympathetic withdrawalParasympathetic functionInsulin levelsMaximal exerciseExercise recoverySympathovagal balanceCardiovascular diseaseRate recoveryNervous systemOveractivityFitness testsYounger cohorts
2006
Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training.
DiPietro L, Dziura J, Yeckel C, Neufer P. Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training. Cardiopulmonary Physical Therapy Journal 2006, 17: 95. DOI: 10.1097/01823246-200617020-00011.Peer-Reviewed Original Research
2005
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. Journal Of Applied Physiology 2005, 100: 142-149. PMID: 16141382, DOI: 10.1152/japplphysiol.00474.2005.Peer-Reviewed Original ResearchConceptsHigh-intensity exercise trainingIntensity exercise trainingExercise trainingAerobic trainingInsulin sensitivityExercise volumeOlder womenGlucose utilizationModerate-intensity aerobic trainingTwo-step euglycemic-hyperinsulinemic clampInsulin-stimulated glucose utilizationHigh-intensity aerobic trainingDual-energy X-ray absorptiometryHigher insulin doseLower insulin doseHealthy older womenEuglycemic hyperinsulinemic clampLow-intensity exerciseTotal body fatAdipose tissue lipolysisImproved glucose utilizationX-ray absorptiometrySuppression of lipolysisFinal exercise boutInsulin-stimulated suppression
2004
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert T, Tamborlane W, Taksali S, Yeckel C, Allen K, Lopes M, Savoye M, Morrison J, Sherwin R, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. Obstetrical & Gynecological Survey 2004, 59: 822-824. DOI: 10.1097/01.ogx.0000140472.10719.95.Peer-Reviewed Original ResearchDegree of obesityMetabolic syndromeC-reactive proteinInsulin resistanceType 2 diabetesCRP levelsGlucose toleranceIL-6Higher C-reactive proteinDegree of dyslipidemiaInsulin-resistant adultsImpaired glucose toleranceIndependent risk factorInterleukin-6 levelsSystolic blood pressureBody mass indexAdvanced cardiovascular diseaseProportion of subjectsHigh-density lipoproteinVascular complicationsAdiponectin levelsBlood pressureObese subjectsMass indexNonobese individualsThe Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance
Yeckel CW, Taksali SE, Dziura J, Weiss R, Burgert TS, Sherwin RS, Tamborlane WV, Caprio S. The Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 747-754. PMID: 15522932, DOI: 10.1210/jc.2004-1258.Peer-Reviewed Original ResearchConceptsBeta-cell responsivenessNormal glucose tolerancePlasma glucose levelsGlucose levelsGlucose toleranceInsulin sensitivityPlasma glucoseObese youthOral glucose tolerance testType 2 diabetes mellitusDecreased insulinogenic indexGlucose tolerance continuumGlucose tolerance testInsulin sensitivity indexContinuum of riskDelta insulinInsulinogenic indexDiabetes mellitusInsulin resistancePlasma levelsTolerance testNormal rangeFunction IndependentDlGlucose concentrationLeg glucose and protein metabolism during an acute bout of resistance exercise in humans
Durham WJ, Miller SL, Yeckel CW, Chinkes DL, Tipton KD, Rasmussen BB, Wolfe RR. Leg glucose and protein metabolism during an acute bout of resistance exercise in humans. Journal Of Applied Physiology 2004, 97: 1379-1386. PMID: 15194677, DOI: 10.1152/japplphysiol.00635.2003.Peer-Reviewed Original ResearchConceptsLeg blood flowResistance exercisePhenylalanine rateLeg glucoseAcute boutBlood flowLactate releaseProtein breakdownWhole-body protein breakdownLower body resistance exerciseGlucose uptakeLeg glucose uptakeLeg lactate releaseBody resistance exerciseVenous blood samplesMuscle protein synthesisProtein metabolismBody protein breakdownExercise regimenExercise boutLeg pressGlutamate uptakeMuscle biopsyProtein synthesisBlood samplesObesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultChildChild, PreschoolC-Reactive ProteinFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesityPostexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise
Sheffield-Moore M, Yeckel CW, Volpi E, Wolf SE, Morio B, Chinkes DL, Paddon-Jones D, Wolfe RR. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise. AJP Endocrinology And Metabolism 2004, 287: e513-e522. PMID: 15149953, DOI: 10.1152/ajpendo.00334.2003.Peer-Reviewed Original ResearchConceptsModerate-intensity aerobic exercisePOST-EXFractional synthesis rateAerobic exerciseOlder menYoung menMixed muscle fractional synthesis rateMuscle metabolismRegular aerobic exerciseAcute aerobic exerciseMuscle fractional synthesis rateProtein metabolismArteriovenous blood samplesMuscle protein turnoverSingle boutAcute effectsMuscle biopsyPhenylalanine kineticsBlood samplesPlasma protein synthesisModerate walkingMenShort-term increasePlasma proteinsExerciseValidation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
2003
Fatty Acid Oxidation
Morio B, Yeckel C, Wolfe R. Fatty Acid Oxidation. 2003 DOI: 10.1038/npg.els.0000633.Peer-Reviewed Original Research
2002
GENDER DIFFERENCES IN FATTY ACID AVAILABILITY DURING MODERATE INTENSITY EXERCISE
Yeckel C, Durham W, Sheffield-Moore M, Chinkes D, Wolf S, Miller S, Wolfe R. GENDER DIFFERENCES IN FATTY ACID AVAILABILITY DURING MODERATE INTENSITY EXERCISE. Medicine & Science In Sports & Exercise 2002, 34: s260. DOI: 10.1097/00005768-200205001-01453.Peer-Reviewed Original Research
2001
BLOOD FLOW EFFECTS ON GLUCOSE UPTAKE FOLLOWING RESISTANCE EXERCISE
Durham W, Yeckel C, Ozkan O, Miller S, Tipton K, Rasmussen B, Wolf S, Walser E, Arsland A, Wolfe R. BLOOD FLOW EFFECTS ON GLUCOSE UPTAKE FOLLOWING RESISTANCE EXERCISE. Medicine & Science In Sports & Exercise 2001, 33: s329. DOI: 10.1097/00005768-200105001-01848.Peer-Reviewed Original Research
2000
Fat metabolism during high-intensity exercise in endurance-trained and untrained men
Coggan A, Raguso C, Gastaldelli A, Sidossis L, Yeckel C. Fat metabolism during high-intensity exercise in endurance-trained and untrained men. Metabolism 2000, 49: 122-128. PMID: 10647075, DOI: 10.1016/s0026-0495(00)90963-6.Peer-Reviewed Original ResearchConceptsHigh-intensity exerciseFree fatty acidsFatty acid oxidationUntrained menIntramuscular triglyceride storesPlasma FFA fluxEndurance-trained menMinutes of exerciseFatty acidsMaximal oxygen consumptionWhole body rateTotal energy expenditureAcid oxidationFFA fluxFFA utilizationIntense exerciseIndirect calorimetryAdditional fatty acidsAdipose tissueFat metabolismTriglyceride storesRate of appearanceUntrained subjectsEnergy expenditureUntrained individuals