Carolina Gomis Perez, PhD
Associate Research ScientistDownloadHi-Res Photo
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Cellular & Molecular Physiology
Nanobiology Institute , 850 West Campus Drive ISTC 220B
West Haven, CT 06516
United States
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Titles
Associate Research Scientist
Appointments
Cellular & Molecular Physiology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Siena, Cellular Physiology (2009)
- MSc
- University of Murcia, Biology and Reproductive Technology (2005)
- BS
- University of Miguel Hernandez, Biochemistry (2004)
Research
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Overview
Medical Research Interests
B-Lymphocytes; Biophysics; Cell Membrane; Electrophysiology; Endocytosis; Exocytosis; Liposomes; Membrane Lipids; Optical Tweezers; Physiology
ORCID
0000-0002-6818-4403- View Lab Website
Karatekin Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Carolina Gomis Perez's published research.
Publications Timeline
A big-picture view of Carolina Gomis Perez's research output by year.
Research Interests
Research topics Carolina Gomis Perez is interested in exploring.
Erdem Karatekin, PhD
Ane Landajuela Larma
David Zenisek, PhD
Stephen Waxman, MD, PhD
Sulayman Dib-Hajj, PhD
Betsy Schulman, PhD
36Publications
671Citations
Electrophysiology
Publications
2025
Polyunsaturated fatty acids control lipid membrane dynamics and ferroptosis sensitivity in B-cell lymphoma
Leveille E, Bramson E, Robinson M, Perez C, Chahal O, Bertomeu T, Chatr-aryamontri A, Kothari S, Gupta K, Karatekin E, Xiao G, Lancaster G, Murphy A, Conrad M, Müschen M. Polyunsaturated fatty acids control lipid membrane dynamics and ferroptosis sensitivity in B-cell lymphoma. Blood 2025, 146: 5094-5094. DOI: 10.1182/blood-2025-5094.Peer-Reviewed Original ResearchConceptsB-cell lymphomaB cellsSensitivity to ferroptosisDegradation tagCompetitive fitnessPUFA metabolismB-cell lymphoma cell linesFerroptosis inducersSensitivity of cancer cellsTherapy-resistant tumorsB-cell malignanciesB cell-dependentExpression of ACSL3Clinical trial cohortDriving metabolismFerroptosis sensitivityB cell activationVulnerability to ferroptosisLymphoma cell linesIron-dependent peroxidationCell deathDrug sensitivity dataMembrane dynamicsSelection pressureConsistent with loss
2024
Cell Membrane Tension Gradients, Membrane Flows, and Cellular Processes
Yan Q, Gomis Perez C, Karatekin E. Cell Membrane Tension Gradients, Membrane Flows, and Cellular Processes. Physiology 2024, 39: 231-245. PMID: 38501962, PMCID: PMC11368524, DOI: 10.1152/physiol.00007.2024.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricNav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia
Nascimento de Lima A, Zhang H, Chen L, Effraim P, Gomis-Perez C, Cheng X, Huang J, Waxman S, Dib-Hajj S. Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain 2024, 147: 3157-3170. PMID: 38447953, DOI: 10.1093/brain/awae071.Peer-Reviewed Original ResearchCitationsConceptsDorsal root ganglion neuronsDorsal root ganglionVincristine-induced mechanical allodyniaVincristine-induced peripheral neuropathyMechanical allodyniaVincristine treatmentNav1.8 channelsSmall dorsal root ganglion neuronsDevelopment of mechanical allodyniaTTX-R current densityVoltage-gated sodium channel Nav1.6Vincristine-treated animalsCurrent-clamp recordingsSodium channel Nav1.8Voltage-clamp recordingsReducing current thresholdSodium channel Nav1.6Investigate pathophysiological mechanismsTTX-RHyperpolarizing shiftRoot ganglionAllodyniaGanglion neuronsVincristine administrationPeripheral neuropathyMembrane fission during bacterial spore development requires cellular inflation driven by DNA translocation
Landajuela A, Braun M, Martínez-Calvo A, Rodrigues C, Perez C, Doan T, Rudner D, Wingreen N, Karatekin E. Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation. Biophysical Journal 2024, 123: 187a-188a. DOI: 10.1016/j.bpj.2023.11.1213.Peer-Reviewed Original ResearchRapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals
Perez C, Dudzinski N, Rouches M, Landajuela A, Machta B, Zenisek D, Karatekin E. Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals. Biophysical Journal 2024, 123: 380a. DOI: 10.1016/j.bpj.2023.11.2322.Peer-Reviewed Original Research
2022
Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation
Landajuela A, Braun M, Martínez-Calvo A, Rodrigues CDA, Gomis Perez C, Doan T, Rudner DZ, Wingreen NS, Karatekin E. Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation. Current Biology 2022, 32: 4186-4200.e8. PMID: 36041438, PMCID: PMC9730832, DOI: 10.1016/j.cub.2022.08.014.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMother cell membraneMembrane fissionMother cellsDNA translocationMembrane tensionLarger mother cellMother cell cytoplasmCell membraneHigh membrane tensionSmaller foresporeDNA translocaseEnergy-limited conditionsForespore compartmentAsymmetric divisionEndospore formationMembrane compartmentsMembrane necksSpore developmentCell divisionMolecular basisForesporeMembrane flowBacillus subtilisCell cytoplasmFisBRapid membrane flow at a presynaptic terminal
Perez C, Dudzinski N, Rouches M, Machta B, Zenisek D, Karatekin E. Rapid membrane flow at a presynaptic terminal. Biophysical Journal 2022, 121: 230a. DOI: 10.1016/j.bpj.2021.11.1599.Peer-Reviewed Original ResearchRapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals
Perez C, Dudzinski NR, Rouches M, Landajuela A, Machta B, Zenisek D, Karatekin E. Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals. Science Advances 2022, 8: eabl4411. PMID: 34985955, PMCID: PMC11580022, DOI: 10.1126/sciadv.abl4411.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMembrane tensionMembrane flowStimulation of exocytosisSynaptic vesicle turnoverNeuroendocrine adrenal chromaffin cellsCell divisionVesicle turnoverCellular activitiesCell migrationCell typesAdrenal chromaffin cellsChromaffin cellsGlobal decreasePresynaptic terminalsRapid propagationEndocytosisExocytosisNeuronal terminalsPhagocytosisTurnoverGradientCellsDivisionMigration
2021
An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel
Urrutia J, Aguado A, Gomis-Perez C, Muguruza-Montero A, Ballesteros OR, Zhang J, Nuñez E, Malo C, Chung HJ, Leonardo A, Bergara A, Villarroel A. An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel. BMC Biology 2021, 19: 109. PMID: 34020651, PMCID: PMC8138981, DOI: 10.1186/s12915-021-01040-1.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsKv7.2 channelsChannel functionSequences of proteinsNon-native configurationsNascent chainsProper foldingEpilepsy-causing mutationsIQ motifResponsive domainHuman diseasesHelix ANative conformationFolding routeIon channelsKCNQ2 geneMutationsNeuronal compartmentsFoldingMisfoldingProteinKey pathogenic mechanismsPathogenic variantsSilico studiesPathogenic mechanismsSide chainsDynamics of Membrane Tension and Synaptic Vesicle Recycling
Perez C, Dudzinski N, Rouches M, Machta B, Zenisek D, Karatekin E. Dynamics of Membrane Tension and Synaptic Vesicle Recycling. Biophysical Journal 2021, 120: 323a. DOI: 10.1016/j.bpj.2020.11.2037.Peer-Reviewed Original ResearchCitations
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Cellular & Molecular Physiology
Nanobiology Institute , 850 West Campus Drive ISTC 220B
West Haven, CT 06516
United States