2017
A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors
Murtha TD, Lupsa BC, Majumdar S, Jain D, Salem RR. A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors. Journal Of Gastrointestinal Surgery 2017, 21: 1335-1341. PMID: 28510792, DOI: 10.1007/s11605-017-3428-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAgedBiomarkers, TumorFemaleHumansInsulinomaMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsProinsulinConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsSystematic reviewRare pancreatic neuroendocrine tumorYale-New Haven HospitalMajority of patientsMedian tumor diameterLower insulin levelsBiomedical databases PubMedNew Haven HospitalSymptomatic hypoglycemiaMost patientsFemale predominanceTumor diameterClinicopathologic featuresInsulin levelsUncommon diseaseMean ageOvid MEDLINEHormonal levelsDatabases PubMedPatientsProinsulinomaHormone productionTumors
2015
Precipitation of Autoimmune Diabetes With Anti-PD-1 Immunotherapy
Hughes J, Vudattu N, Sznol M, Gettinger S, Kluger H, Lupsa B, Herold KC. Precipitation of Autoimmune Diabetes With Anti-PD-1 Immunotherapy. Diabetes Care 2015, 38: e55-e57. PMID: 25805871, PMCID: PMC4370325, DOI: 10.2337/dc14-2349.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2010
Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy
Lupsa BC, Sachdev V, Lungu AO, Rosing DR, Gorden P. Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy. Medicine 2010, 89: 245-250. PMID: 20616664, PMCID: PMC3090142, DOI: 10.1097/md.0b013e3181e9442f.Peer-Reviewed Original ResearchConceptsCohort of patientsGeneralized lipodystrophyCardiac findingsInsulin resistanceHypertrophic cardiomyopathyAcquired Generalized LipodystrophyLower leptin levelsExtreme insulin resistanceDiabetes mellitusLeptin therapyLeptin levelsSevere dyslipidemiaCardiac statusFrequent findingClinical trialsRare disorderPatientsAdipose tissueCardiomyopathyLipodystrophyCongenitalSeipin mutationsUnderlying mechanismPhenotypic featuresCohortTreatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies
Malek R, Chong AY, Lupsa BC, Lungu AO, Cochran EK, Soos MA, Semple RK, Balow JE, Gorden P. Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 3641-3647. PMID: 20484479, PMCID: PMC2913034, DOI: 10.1210/jc.2010-0167.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Cortex HormonesAdultAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAutoantibodiesBlood GlucoseCyclophosphamideDrug Therapy, CombinationFemaleHumansHyperandrogenismHyperglycemiaImmunosuppressive AgentsInsulin ResistanceMaleMiddle AgedReceptor, InsulinRituximabTreatment OutcomeConceptsType B insulin resistanceInsulin resistanceAmelioration of hyperglycemiaPathogenic autoantibody productionSerious adverse eventsRare autoimmune disorderInitiation of treatmentForm of immunosuppressionInsulin receptor autoantibodiesSevere acanthosis nigricansAdverse eventsInsulin therapyMedication regimenPulse corticosteroidsInsulin doseReceptor autoantibodiesAutoantibody productionAcanthosis nigricansAutoimmune disordersGlycated hemoglobinStandardized treatmentTreatment protocolEndocrine parametersPatientsSteroids results
2009
Efficacy of leptin therapy in the different forms of human lipodystrophy
Chong AY, Lupsa BC, Cochran EK, Gorden P. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia 2009, 53: 27. PMID: 19727665, DOI: 10.1007/s00125-009-1502-9.Peer-Reviewed Original ResearchConceptsForms of lipodystrophyLipodystrophy patientsLeptin therapyLeptin replacementSerum triacylglycerolOpen-label prospective studySevere insulin resistanceNational InstituteGlycaemic controlHDL cholesterolLDL cholesterolTotal cholesterolMetabolic abnormalitiesKidney diseaseProspective studyInsulin resistanceRare disorderSustained improvementPatientsAdipose tissueLipodystrophyHuman lipodystrophyPPARγ geneTherapyDyslipidaemia