2010
Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy
Lupsa BC, Sachdev V, Lungu AO, Rosing DR, Gorden P. Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy. Medicine 2010, 89: 245-250. PMID: 20616664, PMCID: PMC3090142, DOI: 10.1097/md.0b013e3181e9442f.Peer-Reviewed Original ResearchConceptsCohort of patientsGeneralized lipodystrophyCardiac findingsInsulin resistanceHypertrophic cardiomyopathyAcquired Generalized LipodystrophyLower leptin levelsExtreme insulin resistanceDiabetes mellitusLeptin therapyLeptin levelsSevere dyslipidemiaCardiac statusFrequent findingClinical trialsRare disorderPatientsAdipose tissueCardiomyopathyLipodystrophyCongenitalSeipin mutationsUnderlying mechanismPhenotypic featuresCohortTreatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies
Malek R, Chong AY, Lupsa BC, Lungu AO, Cochran EK, Soos MA, Semple RK, Balow JE, Gorden P. Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 3641-3647. PMID: 20484479, PMCID: PMC2913034, DOI: 10.1210/jc.2010-0167.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Cortex HormonesAdultAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAutoantibodiesBlood GlucoseCyclophosphamideDrug Therapy, CombinationFemaleHumansHyperandrogenismHyperglycemiaImmunosuppressive AgentsInsulin ResistanceMaleMiddle AgedReceptor, InsulinRituximabTreatment OutcomeConceptsType B insulin resistanceInsulin resistanceAmelioration of hyperglycemiaPathogenic autoantibody productionSerious adverse eventsRare autoimmune disorderInitiation of treatmentForm of immunosuppressionInsulin receptor autoantibodiesSevere acanthosis nigricansAdverse eventsInsulin therapyMedication regimenPulse corticosteroidsInsulin doseReceptor autoantibodiesAutoantibody productionAcanthosis nigricansAutoimmune disordersGlycated hemoglobinStandardized treatmentTreatment protocolEndocrine parametersPatientsSteroids results
2009
Efficacy of leptin therapy in the different forms of human lipodystrophy
Chong AY, Lupsa BC, Cochran EK, Gorden P. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia 2009, 53: 27. PMID: 19727665, DOI: 10.1007/s00125-009-1502-9.Peer-Reviewed Original ResearchConceptsForms of lipodystrophyLipodystrophy patientsLeptin therapyLeptin replacementSerum triacylglycerolOpen-label prospective studySevere insulin resistanceNational InstituteGlycaemic controlHDL cholesterolLDL cholesterolTotal cholesterolMetabolic abnormalitiesKidney diseaseProspective studyInsulin resistanceRare disorderSustained improvementPatientsAdipose tissueLipodystrophyHuman lipodystrophyPPARγ geneTherapyDyslipidaemiaAutoimmune Forms of Hypoglycemia
Lupsa BC, Chong AY, Cochran EK, Soos MA, Semple RK, Gorden P. Autoimmune Forms of Hypoglycemia. Medicine 2009, 88: 141-153. PMID: 19440117, DOI: 10.1097/md.0b013e3181a5b42e.Peer-Reviewed Original ResearchConceptsInsulin autoimmune syndromeType B insulin resistanceAnti-insulin receptor antibodiesAutoimmune syndromeAutoimmune formInsulin resistanceReceptor antibodiesPancreatic surgical proceduresCause of hypoglycemiaNon-Asian patientsAnti-insulin antibodiesNon-Asian populationsLaboratory featuresClinical courseWhite patientsHypoglycemic patientsRare causeInsulin levelsHyperinsulinemic hypoglycemiaSurgical proceduresCorrect diagnosisHypoglycemiaPatientsSyndromeElevated levels