Asawari Korde
Associate Research ScientistCards
About
Research
Publications
2026
C107-04 The Injurious Effect of an RNA 3’Adenyl Transferase in Acute Lung Injury
Korde A, Pierce R, Pober J, Takyar S. C107-04 The Injurious Effect of an RNA 3’Adenyl Transferase in Acute Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.225. DOI: 10.1093/ajrccm/aamag162.225.Peer-Reviewed Original ResearchAcute lung injuryLung injuryLung endothelial cellsBronchoalveolar lavageEndothelial cellsMiR-1 levelsIntranasal deliverySevere manifestationsCell deathAcute respiratory distress syndromeDelivery of lentivirusEndothelial-specific promoterHuman lung endothelial cellsManifestation of acute lung injuryAlveolar-capillary barrier integrityRespiratory distress syndromeDeoxynucleotidyl transferase dUTP nick end labelingTerminal deoxynucleotidyl transferase dUTP nick end labelingTransferase dUTP nick end labelingDUTP nick end labelingMiR-1Lipopolysaccharide (LPS)-induced ALI modelIn vitro knockdown experimentsRNA-based therapeutic approachesLactate dehydrogenaseB21-09 Endothelial Mpl Regulates Tumor Angiogenesis and Immunity in Non Small Cell Lung Cancer
Korde A, Jin L, Zhang J, Karimi N, Moghaddam S, Takyar S. B21-09 Endothelial Mpl Regulates Tumor Angiogenesis and Immunity in Non Small Cell Lung Cancer. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.3786. DOI: 10.1093/ajrccm/aamag162.3786.Peer-Reviewed Original ResearchNon-small-cell lung cancerTumor endothelial cellsVascular endothelial growth factorLewis lung carcinomaTumor angiogenesisEndothelial cellsTumor growthLung cancerXenograft modelNon-small-cell lung cancer patientsNon small cell lung cancerLewis lung carcinoma tumorsMPL levelsSmall cell lung cancerHuman non-small-cell lung cancerHuman pulmonary microvascular ECExpression of P-selectinHuman pulmonary microvascular endothelial cellsRecruitment of inflammatory cellsPrevalence of TregsPulmonary microvascular endothelial cellsTumor-bearing lungsCell lung cancerImmune cell infiltrationGene expression analysisSkin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis
Zielonka J, Li N, Liu Y, Yan X, Wang Z, Ramirez M, Figueroa A, Korde A, Yin H, Britto C, Singh I, Sun H, Herzog E, Feghali‐Bostwick C, Hinchcliff M, Ryu C, Gomez J. Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis. Arthritis & Rheumatology 2026 PMID: 41930625, DOI: 10.1002/art.70163.Peer-Reviewed Original ResearchSSc-ILDSystemic sclerosisStromal cellsMultiorgan involvementSSc-related interstitial lung diseaseKRAS pathwaySevere multiorgan involvementSystemic sclerosis skinInterstitial lung diseaseCutaneous signaturesLung involvementDysregulated immunityCause of deathGene Set Enrichment AnalysisImmune cellsProgressive fibrosisSkin fibrosisLung fibrosisSingle-cell RNA sequencingLung diseaseMicrovascular damageLung impairmentLung functionGene correlation analysisKRASEpidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury
Harris Z, Korde A, Khoury J, Manning E, Stanley G, Shin Y, Mitchell K, von der Schulenburg A, Sun Y, Hu B, Shin H, Joerns J, Clark B, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang M, Koff J. Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury. BMJ Open Respiratory Research 2026, 13: e003323. PMID: 41592865, PMCID: PMC12853440, DOI: 10.1136/bmjresp-2025-003323.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorAcute lung injuryHyperoxic ALIHyperoxic acute lung injuryGrowth factor receptorIn vivo effectsLung injuryOxidant-mediated acute lung injuryFactor receptorIntensive care unit mortalityExposure to high oxygenAlveolar type II cellsDelivery of supplemental oxygenPulmonary cell deathLife-saving therapyPluripotent stem cellsType II cellsNormoxia controlSupplemental oxygenUnit mortalityAlveolar epitheliumBeclin-1Cell death pathwaysStem cellsTherapeutic potential
2025
Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA
Korde A, Ramaswamy A, Anderson S, Jin L, Zhang J, Hu B, Velasco W, Diao L, Wang J, Pisani M, Sauler M, Boffa D, Puchalski J, Yan X, Moghaddam S, Takyar S. Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA. Communications Biology 2025, 8: 511. PMID: 40155749, PMCID: PMC11953391, DOI: 10.1038/s42003-025-07710-y.Peer-Reviewed Original Research
2024
Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract
Mao T, Kim J, Peña-Hernández M, Valle G, Moriyama M, Luyten S, Ott I, Gomez-Calvo M, Gehlhausen J, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee C, Monteiro V, Lucas C, Dong H, Yang Y, Initiative Y, Gopinath S, Wilen C, Palm N, Dela Cruz C, Iwasaki A, Vogels C, Hahn A, Chen N, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Grubaugh N. Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2319566121. PMID: 38648490, PMCID: PMC11067057, DOI: 10.1073/pnas.2319566121.Peer-Reviewed Original ResearchConceptsInterferon-stimulated genesRespiratory infectionsStrains of influenza A virusTreatment of respiratory viral infectionsRespiratory virus infectionsInfluenza A virusMouse model of COVID-19Respiratory viral infectionsNeomycin treatmentExpression of interferon-stimulated genesUpper respiratory infectionInterferon-stimulated gene expressionLower respiratory infectionsBroad spectrum of diseasesAdministration of neomycinRespiratory viral diseasesDisease to patientsUpper respiratory tractIntranasal deliveryCongenic miceIntranasal applicationNasal mucosaSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2A virus
2022
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells
Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells. Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, PMCID: PMC9814191, DOI: 10.1084/jem.20212218.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cellsTLT-1Non-small cell lung cancer patientsCell lung cancer patientsTREM-like transcript-1Tumor immunosuppressive mechanismsT cell suppressionLung cancer patientsPatient T cellsNF-κB pathwayPatient-derived tumorsDistinct activation phenotypesNSCLC patientsImmunosuppressive mechanismsSyngeneic tumorsHumanized miceImmunoregulatory rolePrognostic significanceImmunocompetent miceCancer patientsCell suppressionActivation phenotypeReduced tumorTumor growthCoronavirus Lung Infection Impairs Host Immunity Against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction
Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. Coronavirus Lung Infection Impairs Host Immunity Against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction. The Journal Of Immunology 2022, 209: 1314-1322. PMID: 36165196, PMCID: PMC9523490, DOI: 10.4049/jimmunol.2200198.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Bacterial infectionsMouse modelCoronavirus infectionLysosomal dysfunctionMajor health care challengeLung immune cellsLung tissue damageSecondary bacterial infectionImpair host immunityIL-1β releaseHealth care challengesCell deathPyroptotic cell deathBacterial killing abilityIL-1βBacterial clearanceImmune cellsSecondary infectionHost immunityAlveolar macrophagesTissue damageΒ-coronavirusStructural cellsCare challengesEpidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia‐Induced Lung Injury
Harris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia‐Induced Lung Injury. Oxidative Medicine And Cellular Longevity 2022, 2022: 9518592. PMID: 36193076, PMCID: PMC9526641, DOI: 10.1155/2022/9518592.Peer-Reviewed Original ResearchConceptsAcute lung injuryEpidermal growth factor receptorAlveolar epithelial cellsLung injurySevere hyperoxiaEGFR inhibitionEpithelial cellsHyperoxia-Induced Lung InjuryRole of EGFRMurine alveolar epithelial cellsGrowth factor receptor inhibitionWorse clinical outcomesEpidermal growth factor receptor inhibitionHuman alveolar epithelial cellsWild-type littermatesPoly (ADP-ribose) polymeraseTerminal dUTP nickGrowth factor receptorClinical outcomesImproved survivalReceptor inhibitionLung repairProtective roleComplex roleEGFR deletion
2018
Eosinophil Binding and Activation is Regulated Through the Coordinated Expression of miR-1 Endothelial Targets
Korde A, Ahangari F, Mehta S, Cohn L, Gonzalez A, Takyar S. Eosinophil Binding and Activation is Regulated Through the Coordinated Expression of miR-1 Endothelial Targets. American Journal Of Respiratory And Critical Care Medicine 2018, 197: a1293-a1293. DOI: 10.1164/ajrccm-conference.2018.197.1_meetingabstracts.a1293.Peer-Reviewed Original Research