2022
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal Of Medicine 2022, 387: 205-216. PMID: 35658024, DOI: 10.1056/nejmoa2206038.Peer-Reviewed Original ResearchConceptsBody weightTreatment discontinuationAdverse eventsGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsGlucose-dependent insulinotropic polypeptidePercentage changeDose escalation periodWeight-related complicationsCommon adverse eventsCoprimary end pointsBody mass indexSubstantial global morbidityTreatment of obesityMean percentage changePercentage of participantsMean body weightWeight reductionCardiometabolic measuresTreat populationPlacebo groupWeek 72Mean BMIWeekly dosesDose escalation
2016
American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines for Medical Care of Patients with Obesity
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R, Guidelines R. American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines for Medical Care of Patients with Obesity. Endocrine Practice 2016, 22: 842-884. PMID: 27472012, DOI: 10.4158/ep161356.esgl.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClinical practice guidelinesAmerican CollegePractice guidelinesMedical careAdiposity-based chronic diseaseDetailed evidence-based recommendationsObesity clinical practice guidelinesReal-world medical careComprehensive clinical practice guidelinesClinical Endocrinologists ACEWeight-related complicationsIndividualization of careSelection of therapyEvidence-based recommendationsMedical care planAmerican AssociationQuality of lifeHigh-quality careAACE protocolRecommendation gradesClinical EndocrinologistsClinical evidenceChronic diseasesTreatment goalsCare plansAmerican Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines Formedical Care of Patients with Obesity
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R, Guidelines R. American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines Formedical Care of Patients with Obesity. Endocrine Practice 2016, 22: 1-203. PMID: 27219496, DOI: 10.4158/ep161365.gl.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClinical practice guidelinesAmerican CollegeAdiposity-based chronic diseaseDetailed evidence-based recommendationsReal-world medical careCoronary Artery Risk DevelopmentOral glucose tolerance testClinical Endocrinologists ACEWeight-related complicationsGlucose tolerance testPrevention of diabetesIndividualization of careSelection of therapyBehavioral modificationEvidence-based recommendationsMedical care planAmerican AssociationQuality of lifeHigh-quality careAACE protocolAdjustable gastricSibutramine TrialRecommendation gradesNonpharmacologic interventionsClinical Endocrinologists