2014
Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity
Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity. Diabetes Care 2014, 37: 3061-3068. PMID: 25139883, PMCID: PMC4207200, DOI: 10.2337/dc14-0525.Peer-Reviewed Original ResearchConceptsLow-calorie foodsBrain responsesFood imagesEmotion processingEmotion responsesAdolescent brainNeural responsesNeural activationHigh-calorie food consumptionFood cravingsNeural alterationsBrain rewardFunctional MRIAdolescent obesityRisk of overconsumptionAdolescentsObesity-related metabolic changesEndogenous leptin levelsFood advertisingMetabolic changesYouthDevelopment of obesityType 2 diabetesLean adolescentsNation's youth
2010
Body Mass Index, Metabolic Factors, and Striatal Activation During Stressful and Neutral-Relaxing States: An fMRI Study
Jastreboff AM, Potenza MN, Lacadie C, Hong KA, Sherwin RS, Sinha R. Body Mass Index, Metabolic Factors, and Striatal Activation During Stressful and Neutral-Relaxing States: An fMRI Study. Neuropsychopharmacology 2010, 36: 627-637. PMID: 21048702, PMCID: PMC3055687, DOI: 10.1038/npp.2010.194.Peer-Reviewed Original ResearchConceptsMetabolic factorsFunctional magnetic resonance imagingOB individualsOW/OB individualsVentral striatumVS activationBody mass index statusCortico-limbic regionsNon-homeostatic feedingBody mass indexNormal-weight individualsMagnetic resonance imagingAlcohol cue exposureMass indexObese individualsPlasma glucoseStriatal dysfunctionWeight individualsIndex statusPersonalized stressResonance imagingSignificant associationNW individualsCue exposureMetabolic changes