2016
Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents
Jastreboff AM, Sinha R, Arora J, Giannini C, Kubat J, Malik S, Van Name MA, Santoro N, Savoye M, Duran EJ, Pierpont B, Cline G, Constable RT, Sherwin RS, Caprio S. Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes 2016, 65: 1929-1939. PMID: 27207544, PMCID: PMC5384636, DOI: 10.2337/db15-1216.Peer-Reviewed Original ResearchConceptsObese adolescentsLean adolescentsGlucose ingestionInsulin levelsBrain perfusionBrain regionsSugar-sweetened beverage consumptionAltered brain responsesHedonic brain regionsHippocampal blood flowFurther weight gainFructose ingestionAcyl ghrelinAttenuated suppressionFructose consumptionPerfusion responseBlood flowBrain adaptationBeverage consumptionGreater perfusionPerfusionVentral striatumFunctional MRIWeight gainIngestion
2014
Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity
Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity. Diabetes Care 2014, 37: 3061-3068. PMID: 25139883, PMCID: PMC4207200, DOI: 10.2337/dc14-0525.Peer-Reviewed Original ResearchConceptsLow-calorie foodsBrain responsesFood imagesEmotion processingEmotion responsesAdolescent brainNeural responsesNeural activationHigh-calorie food consumptionFood cravingsNeural alterationsBrain rewardFunctional MRIAdolescent obesityRisk of overconsumptionAdolescentsObesity-related metabolic changesEndogenous leptin levelsFood advertisingMetabolic changesYouthDevelopment of obesityType 2 diabetesLean adolescentsNation's youth
2013
Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions