2022
Epigenetic Age Acceleration Markers Are Associated With Physiologic Frailty and All-Cause Mortality in People With Human Immunodeficiency Virus
Oursler KK, Marconi VC, Wang Z, Xu K, Montano M, So-Armah K, Justice AC, Sun YV. Epigenetic Age Acceleration Markers Are Associated With Physiologic Frailty and All-Cause Mortality in People With Human Immunodeficiency Virus. Clinical Infectious Diseases 2022, 76: e638-e644. PMID: 35970820, PMCID: PMC10169393, DOI: 10.1093/cid/ciac656.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusPhysiologic frailtyVACS IndexCause mortalityMortality discriminationImmunodeficiency virusAge accelerationEpigenetic age accelerationVeterans Aging Cohort Study (VACS) IndexWhite blood cell samplesVACS Index 2.0VACS Index scoreNon-Hispanic blacksIntrinsic epigenetic age accelerationExtrinsic epigenetic age accelerationEpigenome-wide DNA methylationBlood cell samplesHazard ratioOne-year increaseCox regressionMean ageC-statisticIndex scoreMortalityStudy indices
2021
Prostate Cancer Screening and Incidence among Aging Persons Living with HIV
Leapman MS, Stone K, Wadia R, Park LS, Gibert CL, Goetz MB, Bedimo R, Rodriguez-Barradas M, Shebl F, Justice AC, Brown ST, Crothers K, Sigel KM. Prostate Cancer Screening and Incidence among Aging Persons Living with HIV. Journal Of Urology 2021, 207: 324-332. PMID: 34555924, PMCID: PMC8741750, DOI: 10.1097/ju.0000000000002249.Peer-Reviewed Original ResearchConceptsPSA testingHIV statusProstate cancerProstate biopsyCancer incidenceHuman immunodeficiency virus statusProstate-specific antigen (PSA) testingVeterans Aging Cohort StudyProspective national cohortMultivariable Poisson modelsAging Cohort StudySpecific antigen testingHuman immunodeficiency virusProstate cancer screeningUninfected comparatorsCohort studyIncident cancerAntigen testingImmunodeficiency virusMean ageCancer screeningNational cohortCancer stageVirus statusMultivariable modelThe relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system
Satre DD, Levine-Hall T, Sterling SA, Young-Wolff KC, Lam JO, Alexeeff S, Hojilla JC, Williams A, Justice AC, Sterne J, Cavassini M, Bryant KJ, Williams EC, Horberg MA, Volberding P, Weisner C, Silverberg MJ. The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system. Drug And Alcohol Dependence 2021, 219: 108481. PMID: 33429295, PMCID: PMC7869693, DOI: 10.1016/j.drugalcdep.2020.108481.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useHIV care continuum outcomesIntegrated health care systemCare continuum outcomesAlcohol useHealth care systemContinuum outcomesCare continuumOdds ratioHigher oddsKaiser Permanente Northern CaliforniaCare systemHIV RNA controlPrimary care screeningHIV care continuumRelationship of smokingAdjusted odds ratioSeparate logistic regression modelsLogistic regression modelsRace/ethnicityHIV careHIV RNASmoking statusMean ageCare screening
2019
Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial. The Lancet HIV 2019, 6: e509-e517. PMID: 31109915, PMCID: PMC7161741, DOI: 10.1016/s2352-3018(19)30076-1.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeek 24Use disordersAlcohol treatmentAdverse eventsNumber of drinksTreatment medicationsPhysician managementAlcohol abuseMental Disorders-IV criteriaAlcohol-related careFormal alcohol treatmentKey exclusion criteriaTimeline followback methodMotivational enhancement therapyTreat populationHIV clinicHIV outcomesPrimary outcomeSpecialty referralsMean ageUS National InstitutesWeek 4Medical conditionsExclusion criteria
2016
The musculoskeletal diagnosis cohort
Goulet JL, Kerns RD, Bair M, Becker W, Brennan P, Burgess DJ, Carroll CM, Dobscha S, Driscoll M, Fenton BT, Fraenkel L, Haskell S, Heapy A, Higgins D, Hoff RA, Hwang U, Justice AC, Piette JD, Sinnott P, Wandner L, Womack J, Brandt CA. The musculoskeletal diagnosis cohort. Pain 2016, 157: 1696-1703. PMID: 27023420, PMCID: PMC4949131, DOI: 10.1097/j.pain.0000000000000567.Peer-Reviewed Original ResearchConceptsMSD diagnosisMusculoskeletal disordersMSD cohortIndex dateVeterans Health Administration (VHA) careNumeric rating scale scoreICD-9-CM codesCohort inclusion criteriaNontraumatic joint disordersPain-related treatmentsMore outpatient visitsVeterans Health AdministrationMental health diagnosesRating Scale scoresHigher NRS scoresHealth services researchElectronic health recordsDiagnosis cohortSevere painInpatient visitsNRS scoresOutpatient visitsNeck disordersFirst diagnosisMean age
2015
Drinking trajectories among HIV-infected men who have sex with men: A cohort study of United States veterans
Marshall BD, Operario D, Bryant KJ, Cook RL, Edelman EJ, Gaither JR, Gordon AJ, Kahler CW, Maisto SA, McGinnis KA, van den Berg JJ, Zaller ND, Justice AC, Fiellin DA. Drinking trajectories among HIV-infected men who have sex with men: A cohort study of United States veterans. Drug And Alcohol Dependence 2015, 148: 69-76. PMID: 25596785, PMCID: PMC4330114, DOI: 10.1016/j.drugalcdep.2014.12.023.Peer-Reviewed Original ResearchConceptsHazardous alcohol useGeneralized estimates equationsAlcohol useCohort studyVeterans Aging Cohort StudyMean AUDIT-C scoreInfectious disease clinicAging Cohort StudyAlcohol-related diagnosesAUDIT-C scoresAlcohol use trajectoriesConcurrent substance useGroup-based trajectory modelsDisease clinicMean ageEight-year study periodUS veteransMultivariable modelModifiable targetsSelf-report assessmentsHIVAlcohol consumptionUse trajectoriesStudy periodSubstance use
2014
Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults
Althoff KN, McGinnis KA, Wyatt CM, Freiberg MS, Gilbert C, Oursler KK, Rimland D, Rodriguez-Barradas MC, Dubrow R, Park LS, Skanderson M, Shiels MS, Gange SJ, Gebo KA, Justice AC. Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults. Clinical Infectious Diseases 2014, 60: 627-638. PMID: 25362204, PMCID: PMC4318916, DOI: 10.1093/cid/ciu869.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseMyocardial infarctionUninfected adultsAge-associated eventsRenal diseaseHIV statusIncident diagnosisMean ageVeterans Aging Cohort StudyGreater riskCox proportional hazards modelAging Cohort StudyHuman immunodeficiency virusProportional hazards modelNon-AIDSUninfected veteransCohort studyMultivariate linear regression modelMedian ageComparison of risksImmunodeficiency virusAge-associated diseasesImportant confoundersHigh riskHazards modelHIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function.
So-Armah KA, Chang J, Alcorn C, Lo Re V, Baker JV, Tracy R, Butt AA, Agan BK, Rimland D, Gibert CL, Goetz MB, Oursler KK, Rodriguez-Barradas MC, Kuller LH, Brown ST, Stein JH, Skanderson M, Justice AC, Freiberg MS. HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function. Current HIV Research 2014, 12: 50-9. PMID: 25034208, PMCID: PMC4495647, DOI: 10.2174/1570162x1201140716101512.Peer-Reviewed Original ResearchConceptsART initiationHIV infectionHIV infection levelsViral suppressionLongitudinal changesLDL cholesterolPositive HIV antibody testBiomarker measurementsAge-related chronic diseasesAntiretroviral therapy initiationEnd-organ diseaseFIB-4 scoreHIV antibody testWilcoxon signedrank testUninfected veteransVACS-VCFIB-4Therapy initiationHIV levelsHDL cholesterolSerum levelsTotal cholesterolPlatelet countMean ageChronic diseases
2012
Comparing Alcohol Screening Measures Among HIV‐Infected and ‐Uninfected Men
McGinnis KA, Justice AC, Kraemer KL, Saitz R, Bryant KJ, Fiellin DA. Comparing Alcohol Screening Measures Among HIV‐Infected and ‐Uninfected Men. Alcohol Clinical And Experimental Research 2012, 37: 435-442. PMID: 23050632, PMCID: PMC4492202, DOI: 10.1111/j.1530-0277.2012.01937.x.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestUnhealthy alcohol useTimeline Follow-BackComposite International Diagnostic Interview-Substance Abuse ModuleHeavy episodic drinkingAlcohol dependenceAlcohol useRisky drinkingEpisodic drinkingVeterans Aging Cohort StudyReference standardAging Cohort StudyDisorders Identification TestUninfected patientsMale HIVCohort studyMean ageHIVPatientsConsecutive daysClinical useScreening measureIdentification TestDrinkingAfrican AmericansUnhealthy Alcohol and Illicit Drug Use Are Associated With Decreased Quality of HIV Care
Korthuis PT, Fiellin DA, McGinnis KA, Skanderson M, Justice AC, Gordon AJ, Doebler DA, Asch SM, Fiellin LE, Bryant K, Gibert CL, Crystal S, Goetz MB, Rimland D, Rodriguez-Barradas MC, Kraemer KL. Unhealthy Alcohol and Illicit Drug Use Are Associated With Decreased Quality of HIV Care. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2012, 61: 171-178. PMID: 22820808, PMCID: PMC3460799, DOI: 10.1097/qai.0b013e31826741aa.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useIllicit drug useDrug useAlcohol useUnhealthy alcoholHIV careCohort studySubstance useVeterans Aging Cohort StudyRetrospective cohort studyAging Cohort StudySuboptimal health outcomesMultivariable linear regressionSubstance use dataVeteran patientsMean ageMedical recordsMultivariable modelDecreased qualityMAIN OUTCOMEPatientsHealth outcomesHIVMean percentageQuality indicators
2006
Spirituality and Religion in Patients with HIV/AIDS
Cotton S, Puchalski CM, Sherman SN, Mrus JM, Peterman AH, Feinberg J, Pargament KI, Justice AC, Leonard AC, Tsevat J. Spirituality and Religion in Patients with HIV/AIDS. Journal Of General Internal Medicine 2006, 21: s5-s13. PMID: 17083501, PMCID: PMC1924778, DOI: 10.1111/j.1525-1497.2006.00642.x.Peer-Reviewed Original ResearchConceptsHIV/AIDSMean ageSpirituality/religionPatients' mean ageLower overall functioningDuke Religion IndexClinical characteristicsMost patientsHIV symptomsChronic illnessLess alcohol useMultivariable modelDepressive symptomsPatientsFunctional assessmentHealth statusClinical sitesLess alcoholAlcohol usePsychosocial variablesIllnessMean levelsAIDSReligion IndexGreater life satisfaction
2005
Estimating the proportion of patients infected with HIV who will die of comorbid diseases
Braithwaite RS, Justice AC, Chang CC, Fusco JS, Raffanti SR, Wong JB, Roberts MS. Estimating the proportion of patients infected with HIV who will die of comorbid diseases. The American Journal Of Medicine 2005, 118: 890-898. PMID: 16084183, DOI: 10.1016/j.amjmed.2004.12.034.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusComorbid diseasesCombination therapyNaïve human immunodeficiency virusNon-HIV mortalityEffective antiretroviral therapyCells/mm3Proportion of patientsSeparate patient cohortsCopies/mLProportion of deathsLikelihood of deathAntiretroviral therapyObservational cohortHIV infectionTreatment failureViral loadImmunodeficiency virusMean agePatient cohortPatientsSubsequent deathPhenotypic resistanceTherapyCohort
2001
General medical and psychiatric comorbidity among HIV-infected veterans in the post-HAART era
Kilbourne AM, Justice AC, Rabeneck L, Rodriguez-Barradas M, Weissman S, Team F. General medical and psychiatric comorbidity among HIV-infected veterans in the post-HAART era. Journal Of Clinical Epidemiology 2001, 54: s22-s28. PMID: 11750206, DOI: 10.1016/s0895-4356(01)00443-7.Peer-Reviewed Original ResearchConceptsGeneral medical comorbidityMedical comorbiditiesPsychiatric comorbidityHIV comorbidityCognitive impairment/dementiaAntiretroviral drug toxicityPost-HAART eraPrevalence of HIVSignificant depressive symptomsHigh disease burdenLifestyle-associated conditionsComorbidity numberOlder HIVAdult patientsChemical hepatitisHerpes zosterHIV infectionPeripheral neuropathyMean agePsychiatric managementDisease burdenMultisite cohortOral candidiasisRisk drinkingPatient reportsVeterans aging cohort three-site study (VACS 3) overview and description
Smola S, Justice AC, Wagner J, Rabeneck L, Weissman S, Rodriguez-Barradas M, Team F. Veterans aging cohort three-site study (VACS 3) overview and description. Journal Of Clinical Epidemiology 2001, 54: s61-s76. PMID: 11750212, DOI: 10.1016/s0895-4356(01)00448-6.Peer-Reviewed Original ResearchConceptsHIV infectionProvider surveyVeterans Affairs Medical CenterMedian CD4 countVeterans Aging CohortMedian viral loadUse of cigarettesFuture clinical interventionsInfluence of ageCD4 countAntiretroviral medicationsComorbid diseasesDisease clinicViral loadPoor outcomeMean ageThree-site studyAlternative therapiesAge-related differencesCopies/Medical CenterHIVAging CohortTwelve-monthClinical interventions