2024
SENESCENT CELL CLEARANCE PROTECTS THE OVARIAN RESERVE IN AGING MICE
Zhang J, Lopez J, Liang J, Sela M, Kallen A. SENESCENT CELL CLEARANCE PROTECTS THE OVARIAN RESERVE IN AGING MICE. Fertility And Sterility 2024, 122: e21. DOI: 10.1016/j.fertnstert.2024.07.121.Peer-Reviewed Original Research
2023
hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study
Wesevich V, Seckin S, Kelk D, Kallen A, Kodaman P. hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study. Reproductive Biology And Endocrinology 2023, 21: 117. PMID: 38057813, PMCID: PMC10699021, DOI: 10.1186/s12958-023-01150-1.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateFresh embryo transferPeak P levelsPregnancy outcomesEmbryo transferPregnancy rateIVF stimulationCohort studyHigher clinical pregnancy rateOvarian hyperstimulation IVFSingle fertility centerMethodsRetrospective cohort studyRetrospective cohort studyClinical pregnancy outcomesDay of triggerFrozen embryo transferMultivariable logistic modelLower pregnancy ratesP riseEndometrial receptivityProvider recommendationFertility centerProgesterone levelsConclusionsOur dataHigher LBR
2020
Emerging roles for noncoding RNAs in female sex steroids and reproductive disease
Zhang R, Wesevich V, Chen Z, Zhang D, Kallen AN. Emerging roles for noncoding RNAs in female sex steroids and reproductive disease. Molecular And Cellular Endocrinology 2020, 518: 110875. PMID: 32668269, PMCID: PMC7609472, DOI: 10.1016/j.mce.2020.110875.Peer-Reviewed Original ResearchConceptsRole of ncRNAsSteroid hormone productionFemale gametogenesisNcRNA expressionRegulatory networksDNA blueprintNoncoding RNAsFunctional RNAsCentral dogmaNcRNAsBiological processesMolecular biologyRNAMessenger RNAParticular disease stateHormone productionSex steroid hormone productionCritical roleProteinTherapeutic targetReproductive pathologiesPotential diagnostic markerPolycystic ovary syndromeReproductive diseasesFemale sex steroidsUpdates on molecular and environmental determinants of luteal progesterone production
DeWitt NA, Whirledge S, Kallen AN. Updates on molecular and environmental determinants of luteal progesterone production. Molecular And Cellular Endocrinology 2020, 515: 110930. PMID: 32610113, PMCID: PMC7484338, DOI: 10.1016/j.mce.2020.110930.Peer-Reviewed Original ResearchConceptsProgesterone productionKey sex steroidsLuteal progesterone productionGranulosa cell functionCAMP/PKA pathwayLuteal progesteroneEarly pregnancyGonadotropin stimulationProgesterone levelsSex steroidsHormonal factorsClassic mediatorsCorpus luteumNarrative reviewCritical hormoneSteroid hormonesExogenous environmental chemicalsCell functionEnvironmental chemicalsHormoneRecent evidenceEndogenous hormonesProgesteronePKA pathwayLocal productionControl of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling
Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling. Reproductive Sciences 2020, 27: 2063-2074. PMID: 32542534, PMCID: PMC7529825, DOI: 10.1007/s43032-020-00225-3.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationLargest human genome-wide association studyGrowth activationHuman genome-wide association studiesGenome-wide association studiesLigand/receptor interactionsTranscription factor NFκBInhibitory protein IκBαAssociation studiesIκB proteinsWild-type controlsInhibitory proteinProtein IκBαPrimordial stageNFκB signalingMechanistic insightsReceptor interactionProteinMurine ovariesNFκB pathwayKey membersNFκBSubunit p65NFκB activationIκBβThe relationship between H19 and parameters of ovarian reserve
Xia X, Burn MS, Chen Y, Karakaya C, Kallen A. The relationship between H19 and parameters of ovarian reserve. Reproductive Biology And Endocrinology 2020, 18: 46. PMID: 32404103, PMCID: PMC7218823, DOI: 10.1186/s12958-020-00578-z.Peer-Reviewed Original ResearchConceptsOvarian reserveDecreased ovarian reserveOocyte retrievalH19 expressionInfertility evaluationCumulus cellsTransvaginal oocyte retrievalDiminished ovarian reserveAnti-Mullerian hormoneDownregulation of H19H19 expression levelsGazi University SchoolParticipantsA totalAMH levelsSerum AMHIVF patientsOocyte yieldLow respondersBlood samplesNovel biomarkersExpression levelsFurther studiesPatientsUniversity SchoolH19
2019
A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19/let-7 axis
Qin C, Xia X, Fan Y, Jiang Y, Chen Y, Zhang N, Uslu B, Johnson J, Kallen AN. A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19/let-7 axis. Biology Of Reproduction 2019, 101: 257-257. PMID: 31286140, PMCID: PMC6614579, DOI: 10.1093/biolre/ioz046.Peer-Reviewed Original ResearchA counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed
Seifer DB, Kallen AN. A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed. Fertility And Sterility 2019, 111: 1109-1110. PMID: 31056317, DOI: 10.1016/j.fertnstert.2019.03.017.Peer-Reviewed Original ResearchTranslational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB)
Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.Peer-Reviewed Original ResearchConceptsTranslational activationBinding proteinSpecific protein complexesTranslation of mRNAsOocyte maturationCis-acting sequencesEarly embryo developmentProtein complexesXenopus modelEarly embryosKey regulatorGene expressionMolecular mechanismsEmbryo developmentTargeted disruptionMechanistic detailsProteinEarly developmentMRNAMice resultsKey mechanismOocytesActivationMaturationTranscription
2018
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationDormant primordial folliclesRecovery of eggsCare treatmentHuman ovaryCommon causeLive birthsPrimordial folliclesOocyte qualityOvarian folliclesHealthy offspringGrowth activationReproductive technologiesFolliclesBirthHigh-quality eggsActivationEpigenetic strategiesInfertilityWomen
2016
The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis
Men Y, Fan Y, Shen Y, Lu L, Kallen AN. The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis. Endocrinology 2016, 158: 402-409. PMID: 27813675, PMCID: PMC5413078, DOI: 10.1210/en.2016-1340.Peer-Reviewed Original ResearchConceptsSteroidogenic acute regulatory proteinRegulatory proteinsAcute regulatory proteinPost-transcriptional levelRate-limiting stepMicroRNA let-7H19/letRegulation of reproductionMurine cell linesLet-7Overexpression of H19Long noncoding RNA H19Regulation of steroidogenesisCellular growthSpecific tissuesNovel mechanismMultiple rolesNovel targetRNA H19StAR expressionExpression variesCell linesRegulationH19Protein
2015
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.Peer-Reviewed Original ResearchConceptsIVF-intracytoplasmic sperm injectionMiR-21-5p expressionPoor respondersMiR-21-5pMiR-21-3pCumulus cellsHuman granulosa-like tumor cellsMicro-ribonucleic acid (miRNA) expressionMiR-21-3p expressionLower serum E2 levelsMiR-21Elevated expressionPoor ovarian responseSerum E2 levelsReverse transcription real-time polymerase chain reactionTranscription real-time polymerase chain reactionNumber of oocytesLower E2 concentrationsAcademic medical centerReal-time polymerase chain reactionRespective age groupsMicroRNA microarray analysisOvarian responseAltered miRNA expressionE2 levelsBlood type predicts live birth in the infertile population
Goldsammler M, Jindal SK, Kallen A, Mmbaga N, Pal L. Blood type predicts live birth in the infertile population. Journal Of Assisted Reproduction And Genetics 2015, 32: 551-555. PMID: 25701141, PMCID: PMC4380903, DOI: 10.1007/s10815-015-0441-2.Peer-Reviewed Original ResearchConceptsIVF cycle outcomesIU/LLive birthsBlood type ABlood type BBlood typeBaseline FSHInfertile womenCycle outcomeMultivariable logistic regression analysisIVF cycle parametersBlood type OPatient's blood typeType BLogistic regression analysisType AType OOvulatory infertilityPatient characteristicsIVF outcomesMethodsRetrospective studyInfertile populationHigher oddsAcademic centersInfertilityThink heterotopic pregnancy
Macklon N, Fatemi H, Norman R, Patrizio P, Kallen A. Think heterotopic pregnancy. 2015, 105-107. DOI: 10.1017/cbo9781139794671.031.Peer-Reviewed Original Research
2014
HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling
Kallen AN, Haines K, Taylor HS. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. Reproductive Sciences 2014, 21: 892-897. PMID: 24532216, PMCID: PMC4107567, DOI: 10.1177/1933719113519168.Peer-Reviewed Original ResearchDynamic intracellular networkExpression levelsProtein expressionCell linesMammalian cytoskeletonEndometrial epithelial cell lineCytoskeletal remodelingEpithelial cell lineIntracellular networksGene expressionCytoskeletal changesQuantitative real-time polymerase chain reactionRegulate expressionHuman endometrial epithelial cell lineMessenger RNACytokeratin 15Cellular architectureKeratin filamentsEpithelial remodelingExpression decreasesTotal RNAHuman endometrial epithelial cellsHuman endometriumReal-time polymerase chain reactionEpithelial cells
2013
Hormone Therapy
Fischer C, Kallen AN, Pal L. Hormone Therapy. Menopause The Journal Of The North American Menopause Society 2013, 20: 1204-1206. PMID: 23921519, DOI: 10.1097/gme.0b013e31829cd38d.Peer-Reviewed Original ResearchThe Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs. Molecular Cell 2013, 52: 101-112. PMID: 24055342, PMCID: PMC3843377, DOI: 10.1016/j.molcel.2013.08.027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell DifferentiationComputational BiologyDatabases, GeneticGene Expression ProfilingGene Expression RegulationGenomic ImprintingGenotypeHEK293 CellsHuman Umbilical Vein Endothelial CellsHumansMiceMicroRNAsMuscle DevelopmentMyoblasts, SkeletalPhenotypeRibonucleoproteinsRNA InterferenceRNA, Long NoncodingTime FactorsTransfectionConceptsLet-7 familyWide transcriptome analysisHuman genetic disordersNoncanonical binding siteLet-7 microRNALet-7 overexpressionGene functionH19 depletionTranscriptome analysisMuscle differentiationMolecular spongeUnexpected modeImportant regulatorAdult muscleH19 knockdownRecent implicationMiR-675Physiological significanceMicroRNAsH19Binding sitesGenetic disordersOverexpressionImportant roleFetal tissuesAberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report.
Kallen AN, Luk J, Pal L. Aberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report. The Journal Of Reproductive Medicine 2013, 58: 256-60. PMID: 23763012.Peer-Reviewed Original ResearchConceptsEarly pregnancyOI cyclesFollicular responseOvulation inductionSerum progesteroneTreatment cyclesEmbryonic exposureBeta-hCG testingEarly intrauterine pregnancyRepeat treatment cyclesLow serum levelsProgression of pregnancyIntrauterine pregnancyReview of literatureThin endometriumOvarian responseSerum levelsFertility drugsTransvaginal ultrasoundEstradiol levelsSuccessful pregnancyInfertile patientsCase reportPregnancy progressionRepeat treatment
2012
Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?
Kallen AN, Ma J, Huang Y. Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs? Frontiers In Genetics 2012, 3: 240. PMID: 23162570, PMCID: PMC3499807, DOI: 10.3389/fgene.2012.00240.Peer-Reviewed Original ResearchRNA helicase ARibonucleoprotein complexesDEAD-box protein familyMiRNA-mediated repressionATP-dependent unwindingTranslation of genesStimulation of translationFamily of miRNAsSubset of miRNAsRNA helicasesProtein familyTarget mRNAsSame mRNAGene expressionPleiotropic rolesLin28Mode of actionRNA duplexesCell growthNeuronal cellsMiRNAsMRNAComplementary sequencesBrain synaptic functionSynaptic function
2011
Cardiovascular disease and ovarian function
Kallen AN, Pal L. Cardiovascular disease and ovarian function. Current Opinion In Obstetrics & Gynecology 2011, 23: 258-267. PMID: 21681091, DOI: 10.1097/gco.0b013e3283488a21.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHormone therapyCHD riskOvarian functionExogenous estrogenCHD risk profileFemale reproductive hormonesProcess of atherosclerosisExogenous hormone therapyCause of deathProcess of atherogenesisEndogenous ovarian estrogensDuration of exposurePostmenopausal womenCardiac benefitsOvarian hormonesVascular protectionMenopausal womenOvarian estrogenHeart diseaseCardiovascular diseaseEstrogenic milieuOvarian senescenceReproductive hormonesOvarian physiology