2023
Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck
Jiang W, Friedlaender G, Lindskog D, Latich I, Lee F. Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck. CardioVascular And Interventional Radiology 2023, 46: 649-657. PMID: 37052716, DOI: 10.1007/s00270-023-03425-x.Peer-Reviewed Original ResearchMeSH KeywordsFemaleFemur HeadFracture Fixation, IntramedullaryHemiarthroplastyHumansMalePainRetrospective StudiesTreatment OutcomeConceptsOsteolytic lesionsFemoral headSurgical complicationsRevision proceduresLong intramedullary nailingResultsSixty-seven patientsPost-operative complicationsEffective alternative treatmentTraditional surgical approachesAmbulatory scoreCombined painPrimary outcomeMedical complicationsMetastatic lesionsOncologic careRetrospective studyIntramedullary nailingSurgical approachFunction scoresNeck lesionsEarly improvementIM groupHemiarthroplastyComparative efficacyAlternative treatment
2001
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions.
Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s151-8. PMID: 11314793, PMCID: PMC1425155, DOI: 10.2106/00004623-200100002-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationCollagenDrug CarriersDrug Delivery SystemsFemaleFracture Fixation, IntramedullaryFracture HealingFractures, UnunitedHumansMaleProspective StudiesRadiographyRecombinant ProteinsTibial FracturesTransforming Growth Factor betaConceptsTibial nonunionAdverse eventsRadiographic resultsClinical trialsOsteogenic protein-1Bone autograftAutogenous boneChronic donor site painAutograft-treated patientsFresh autogenous bonePlain radiographic evaluationMulti-center clinical trialPercent of patientsSeverity of painDonor site painGroup of patientsProtein 1Bone morphogenetic proteinNumerous animal modelsInvestigational device exemptionDonor site morbiditySame time pointsType ISite painClinical courseOP-1 clinical studies.
Friedlaender G. OP-1 clinical studies. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s160-1. PMID: 11314795, DOI: 10.2106/00004623-200100002-00012.Peer-Reviewed Original ResearchBone Morphogenetic Protein 2Bone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationChemokine CX3CL1Chemokines, CX3CChemokines, CXCFracture Fixation, IntramedullaryFractures, UnunitedHumansMembrane ProteinsRandomized Controlled Trials as TopicTibial FracturesTransforming Growth Factor beta
1985
Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat
Warren S, Pelker R, Friedlaender G. Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat. Journal Of Orthopaedic Research® 1985, 3: 96-100. PMID: 3981300, DOI: 10.1002/jor.1100030112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaBone and BonesCyclosporinsDrug Evaluation, PreclinicalFemaleFemoral FracturesFracture Fixation, IntramedullaryRatsRats, Inbred StrainsTime FactorsWound HealingConceptsControl animalsSolid organ allograft survivalFracture repairCurrent biomechanical dataOrgan allograft survivalShort-term cyclosporinBiomechanical propertiesSolid organ transplantationEffect of cyclosporinShort-term clinical useMidshaft femoral fractureNew immunosuppressant drugsAllograft survivalFemoral fracturesBone turnoverRat modelSkeletal toxicityOrgan transplantationSystemic effectsHistomorphometric studyImmunosuppressant drugsIntramedullary pinBiologic effectsFractured femurCyclosporin
1984
Radiation‐induced alterations of fracture healing biomechanics
Pelker R, Friedlaender G, Panjabi M, Kapp D, Doganis A. Radiation‐induced alterations of fracture healing biomechanics. Journal Of Orthopaedic Research® 1984, 2: 90-96. PMID: 6491804, DOI: 10.1002/jor.1100020114.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone NailsFemoral FracturesFracture Fixation, IntramedullaryRadiation DosageRadiation Injuries, ExperimentalRatsTime FactorsWound Healing
1975
Treatment of pathological fractures.
Friedlaender G, Johnson R, Brand R, Southwick W. Treatment of pathological fractures. Connecticut Medicine 1975, 39: 765-72. PMID: 1204339.Peer-Reviewed Original Research