Dionisios Sakkas, PhD
About
Research
Publications
2025
The impact of PGT-A on time to live birth in IVF.
Eliner Y, Foley B, Bayer S, Thornton K, Penzias A, Sakkas D, Vaughan D. The impact of PGT-A on time to live birth in IVF. Fertility And Sterility 2025 PMID: 40222699, DOI: 10.1016/j.fertnstert.2025.04.006.Peer-Reviewed Original ResearchPGT-ALive birth rateLive birthsTime to pregnancyOocyte retrievalAge groupsHazard ratioNon-PGT-A groupPre-implantation genetic testingUniversity-affiliated fertility centerPGT-A groupShorter time to pregnancyPositive pregnancy rateSignificant differenceKaplan-Meier curvesBirth rateOne-year periodStatistically significant differencePropensity score matchingMiscarriage rateYounger age groupsNo significant differenceYounger patientsOlder age groupsEgg retrievalCould metabolic imaging and artificial intelligence provide a novel path to non-invasive aneuploidy assessments? A certain clinical need
Horta F, Sakkas D, Ledger W, Goldys E, Gilchrist R. Could metabolic imaging and artificial intelligence provide a novel path to non-invasive aneuploidy assessments? A certain clinical need. Reproduction Fertility And Development 2025, 37 PMID: 39874158, DOI: 10.1071/rd24122.Peer-Reviewed Original ResearchConceptsPGT-AMetabolic imagingAneuploid embryosEmbryo biopsyEmbryo selectionNon-invasive PGT-APre-implantation genetic testingEnhancing embryo selectionNon-invasive metabolic imagingAneuploidy assessmentEmbryo ploidyGenetic testingInvasive natureClinical practicePotential mosaicismClinical needBiopsyFluorescence lifetime imaging microscopyTreatment costsAneuploidyActivation signatureMeasuring cellular metabolismHuman fibroblastsNon-invasive technologyDiagnostic practice
2024
The ‘golden fleece of embryology’ eludes us once again: a recent RCT using artificial intelligence reveals again that blastocyst morphology remains the standard to beat
Sakkas D. The ‘golden fleece of embryology’ eludes us once again: a recent RCT using artificial intelligence reveals again that blastocyst morphology remains the standard to beat. Human Reproduction 2024, 40: 4-8. PMID: 39602554, DOI: 10.1093/humrep/deae263.Peer-Reviewed Original ResearchValidation of a mail-in delayed semen analysis protocol developed for home collection
Racicot K, Sakkas D, Barrett B, Chiang K, Jenkins C. Validation of a mail-in delayed semen analysis protocol developed for home collection. F&S Reports 2024, 5: 378-384. PMID: 39781085, PMCID: PMC11705597, DOI: 10.1016/j.xfre.2024.10.005.Peer-Reviewed Original ResearchComprehensive semen analysisTotal motilityClinical concordanceSemen analysisStudy AFertility clinicsRemnant samplesClinical diagnostic laboratoriesClinical reference rangeSemen specimensProspective validationReference rangesStudy BFertility assessmentMorphological measurementsHome collectionMotilityStudy periodPaired measurementsDiagnostic laboratoriesClinicShipment of specimensConcordanceLaboratory servicesDo sperm factors influence embryonic aneuploidy? Long live the oocyte
Fouks Y, Vaughan D, Sripada V, Penzias A, Bortoletto P, Sakkas D. Do sperm factors influence embryonic aneuploidy? Long live the oocyte. Human Reproduction 2024, 39: 2442-2452. PMID: 39352944, DOI: 10.1093/humrep/deae224.Peer-Reviewed Original ResearchImpact of male ageSperm qualityPloidy ratesPGT-AEmbryonic aneuploidyFrozen embryo transfer cyclesSperm-related factorsEmbryo transfer cyclesPGT-A cyclesPreimplantation genetic testingPropensity score matching analysisClinically significant interactionsRetrospective cohort studyMatching analysisScore matching analysisClinically relevant factorsSperm quality parametersPatient levelPatient-level analysisSemen quality parametersEffect of maternal ageAneuploid blastocystsEmbryo mosaicismSperm factorAneuploidy rateFINAL RESULTS OF A MULTICENTER STUDY COMPARING CELL-FREE DNA AND TROPHECTODERM BIOPSIES IN 2539 HUMAN BLASTOCYSTS
Sanchez L, Sakkas D, Frantz N, Soscia D, Venier W, De La Fuente Lucena E, Bisioli C, Teke B, Barroso G, Perilla D, Simon C, Lluesa C. FINAL RESULTS OF A MULTICENTER STUDY COMPARING CELL-FREE DNA AND TROPHECTODERM BIOPSIES IN 2539 HUMAN BLASTOCYSTS. Fertility And Sterility 2024, 122: e327-e328. DOI: 10.1016/j.fertnstert.2024.07.987.Peer-Reviewed Original ResearchMODIFIED NATURAL FET CYCLES HAVE EQUIVALENT LIVE BIRTH RATES TO PROGRAMMED IN PATIENTS WITH PCOS
Farrell A, Morse B, Vaughan D, Sakkas D, Thornton K, Toth T. MODIFIED NATURAL FET CYCLES HAVE EQUIVALENT LIVE BIRTH RATES TO PROGRAMMED IN PATIENTS WITH PCOS. Fertility And Sterility 2024, 122: e251-e252. DOI: 10.1016/j.fertnstert.2024.07.790.Peer-Reviewed Original ResearchINVESTIGATING THE ETHICAL PERMISSIBILITY OF OFFERING THE OPPORTUNITY TO SELECT THE SEX OF EMBRYOS FOR TRANSFER: AN ANALYSIS OF A CLINIC’S SEX SELECTION PRACTICES AND OUTCOMES
Huttler A, Vaughan D, Morse B, Duvall D, Sakkas D, Heyward Q, Sabbagh R, Penzias A. INVESTIGATING THE ETHICAL PERMISSIBILITY OF OFFERING THE OPPORTUNITY TO SELECT THE SEX OF EMBRYOS FOR TRANSFER: AN ANALYSIS OF A CLINIC’S SEX SELECTION PRACTICES AND OUTCOMES. Fertility And Sterility 2024, 122: e180-e181. DOI: 10.1016/j.fertnstert.2024.07.616.Peer-Reviewed Original ResearchTHE ROLE OF PYRUVATE IN IMPROVING MATURATION RATES AFTER RESCUE IN VITRO MATURATION OF GERMINAL VESICLE STAGE OOCYTES
Ardestani G, Venturas M, Penalver R, Espuny J, Cruz E, Sakkas D. THE ROLE OF PYRUVATE IN IMPROVING MATURATION RATES AFTER RESCUE IN VITRO MATURATION OF GERMINAL VESICLE STAGE OOCYTES. Fertility And Sterility 2024, 122: e355. DOI: 10.1016/j.fertnstert.2024.08.105.Peer-Reviewed Original ResearchUNVEILING SUBSTANTIAL DISCREPANCIES AMONG EXPANDED CARRIER SCREENING PANELS IN REPRODUCTIVE MEDICINE: A COMPREHENSIVE COMPARATIVE ANALYSIS INVOLVING OVER 24,000 PATIENTS
Fabbro M, Zambelli F, Sakkas D, Miguel-Escalada I, Guillen J, Menazzi S, Galain M, Caviglia E, Díaz Y, Papier S, Lattes K, Lorenzon A, Buratini J, Lindenberg F, Popovic M, Fernandez C. UNVEILING SUBSTANTIAL DISCREPANCIES AMONG EXPANDED CARRIER SCREENING PANELS IN REPRODUCTIVE MEDICINE: A COMPREHENSIVE COMPARATIVE ANALYSIS INVOLVING OVER 24,000 PATIENTS. Fertility And Sterility 2024, 122: e274. DOI: 10.1016/j.fertnstert.2024.07.859.Peer-Reviewed Original Research