2010
Astrocytes and Epilepsy
de Lanerolle NC, Lee TS, Spencer DD. Astrocytes and Epilepsy. Neurotherapeutics 2010, 7: 424-438. PMID: 20880506, PMCID: PMC5084304, DOI: 10.1016/j.nurt.2010.08.002.Peer-Reviewed Original ResearchConceptsSeizure focusReactive astrocytesCausation of seizuresGlial fibrillary acidic proteinHippocampal seizure focusRole of astrocytesTemporal lobe epilepsyFibrillary acidic proteinPositive reactive astrocytesNonsclerotic hippocampiHippocampal sclerosisSclerotic hippocampusSubicular neuronsLobe epilepsyEpileptiform activityInflammatory functionsAstrocytesAction potentialsAcidic proteinPotassium ion channelsVascular interfaceEpilepsyHippocampusPrecise roleHuman brain
1999
Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy
Spencer S, Kim J, DeLanerolle N, Spencer D. Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy. Epilepsia 1999, 40: 708-712. PMID: 10368067, DOI: 10.1111/j.1528-1157.1999.tb00767.x.Peer-Reviewed Original ResearchConceptsGlial densityTemporal lobe epilepsyNeuronal densitySpontaneous seizuresLobe epilepsyIctal dischargesSeizure onsetMesial temporal lobe epilepsyElectrical seizure durationHippocampal seizure onsetPercentage of seizuresInterictal-ictal transitionEEG recordingsSeizure durationSeizure parametersPatient's seizuresSeizure propagationPathologic analysisHippocampal fieldsEpilepsy pathogenesisIntracranial EEG recordingsTL resectionSeizuresSynaptic changesPatients
1995
Hippocampal MRI volumetrics and temporal lobe substrates in medial temporal lobe epilepsy
Luby M, Spencer D, Kim J, deLanerolle N, McCarthy G. Hippocampal MRI volumetrics and temporal lobe substrates in medial temporal lobe epilepsy. Magnetic Resonance Imaging 1995, 13: 1065-1071. PMID: 8750318, DOI: 10.1016/0730-725x(95)02014-k.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyNeuronal cell lossTemporal lobe epilepsySignificant neuronal cell lossComplete seizure controlMesial temporal sclerosisSeizure controlHippocampal atrophyLobe epilepsyCell lossMagnetic resonance imagingMRI volumetricsMass lesionLoss groupMTS groupTemporal lobeVolumetric atrophyCA fieldsCell countIntractable temporal lobe seizuresMesial temporal sclerosis groupTemporal lobe epilepsy groupAnteromedial temporal lobe resectionGlial cell countsInvasive electrode monitoring