2001
Ibotenate Injections into the Pre‐ and Parasubiculum Provide Partial Protection against Kainate‐Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex
Eid T, Du F, Schwarcz R. Ibotenate Injections into the Pre‐ and Parasubiculum Provide Partial Protection against Kainate‐Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex. Epilepsia 2001, 42: 817-824. PMID: 11488878, DOI: 10.1046/j.1528-1157.2001.042007817.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIIIbotenate injectionLobe epilepsySeizure-induced damageLoss of neuronsLayer III neuronsRat entorhinal cortexEpileptic damagePartial neuroprotectionExcitatory afferentsPrimary lesionSeizure activityEntorhinal neuronsAnimal modelsIbotenate lesionsPartial protectionLesionsNeuronsKainatePresubiculumEpilepsySerial reconstructionCortex
2000
Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy?
SCHWARCZ R, EID T, DU F. Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy? Annals Of The New York Academy Of Sciences 2000, 911: 328-342. PMID: 10911883, DOI: 10.1111/j.1749-6632.2000.tb06735.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIILobe epilepsySeizure-induced cell deathProminent excitatory inputSeizure-induced deathLayer III neuronsAminooxyacetic acidAOAA injectionPreferential lesionGABAergic neuronsNeuron lossLimbic structuresExcitatory inputsPathological changesParahippocampal structuresAnimal modelsEpilepsyNeuronsLesionsCell deathCortexDeathInjection
1999
Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures
Eid T, Schwarcz R, Ottersen OP. Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures. Experimental Brain Research 1999, 125: 463-475. PMID: 10323293, DOI: 10.1007/s002210050704.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIIMedial entorhinal cortexAminooxyacetic acidGABA-immunoreactive neuronsTemporal lobe seizuresAcid-induced seizuresGABA-like immunoreactivityDifferent animal modelsHippocampal region CA1AOAA injectionSimilar neuropathologySwollen dendritesBehavioral seizuresGABA neuronsLobe epilepsyNeuronal profilesNeuropathological changesPyramidal neuronsNerve terminalsAxon terminalsRat medialDendritic spinesLight microscopic preparations
1997
Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study
Du F, Eid T, Schwarcz R. Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study. Neuroscience 1997, 82: 1165-1178. PMID: 9466438, DOI: 10.1016/s0306-4522(97)00354-0.Peer-Reviewed Original ResearchConceptsSilver-stained neuronsTemporal lobe epilepsyEntorhinal cortexAcid injectionNeuronal damageLobe epilepsyLayer IIIProlonged seizure activitySilver impregnation studyReactive glial cellsPattern of neurodegenerationHippocampal CA1 fieldLateral amygdaloid nucleusRat entorhinal cortexAminooxyacetic acidAmino-oxyacetic acidMedial entorhinal cortexDegenerated neuronsNeuropathological consequencesDamaged neuronsSeizure activityAmygdaloid nucleusMost neuronsNeuronal deathCA1 field
1996
Afferents to the seizure-sensitive neurons in layer III of the medial entorhinal area: a tracing study in the rat
Eid T, Jorritsma-Byham B, Schwarcz R, Witter MP. Afferents to the seizure-sensitive neurons in layer III of the medial entorhinal area: a tracing study in the rat. Experimental Brain Research 1996, 109: 209-218. PMID: 8738371, DOI: 10.1007/bf00231782.Peer-Reviewed Original ResearchConceptsMedial entorhinal areaEntorhinal areaLayer IIIThalamic nucleiIontophoretic injectionVentral portionSeptum-diagonal band complexRetrograde tracer Fast BlueAnteroventral thalamic nucleusTemporal lobe epilepsyAnterograde tracing techniquesAnteromedial thalamic nucleusNucleus raphe dorsalisTracer Fast BlueLateral entorhinal areaAmino-oxyacetic acidLimbic seizuresLobe epilepsyNeuronal vulnerabilityVentrolateral hypothalamusSurgical specimensAnterograde tracerLayer IVRaphe dorsalisFast Blue
1995
Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region
Eid T, Du F, Schwarcz R. Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region. Neuroscience 1995, 68: 645-656. PMID: 8577365, DOI: 10.1016/0306-4522(95)00183-j.Peer-Reviewed Original ResearchConceptsAcute behavioral seizuresBehavioral seizuresDizocilpine maleateNeuronal lossEntorhinal cortexEndogenous N-methyl-D-aspartate receptor agonistN-methyl-D-aspartate receptor antagonist dizocilpine maleateLayer IIIN-methyl-D-aspartate receptor agonistParahippocampal regionN-methyl-D-aspartate (NMDA) receptor subtypeDifferential neuronal vulnerabilityDorsal perirhinal cortexPreferential neuronal lossTemporal lobe epilepsyChloral hydrate anesthesiaLower anesthetic doseNeuropathological sequelaeLobe epilepsyNeuropathological changesLayer VNeuronal vulnerabilityPreferential degenerationAnesthetic doseReceptor agonistPreferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.Peer-Reviewed Original ResearchConceptsPreferential neuronal lossTemporal lobe epilepsyNeuronal lossMedial entorhinal cortexEntorhinal cortexLayer IIILobe epilepsyRat modelIntractable temporal lobe epilepsyAcute status epilepticusLithium/pilocarpineParvalbumin-positive neuronsIntracellular calcium ion concentrationKainic acid administrationNerve cell lossAdult male ratsInjection of diazepamSurviving neuronsProlonged seizuresStatus epilepticusAcid administrationNissl stainingVentral hippocampusKainic acidPathological elevation