2024
Mapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2023
Functional brain networks reflect spatial and temporal autocorrelation
Shinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.Peer-Reviewed Original Research
2022
Coordinated anatomical and functional variability in the human brain during adolescence
Bero J, Li Y, Kumar A, Humphries C, Nag S, Lee H, Ahn W, Hahn S, Constable R, Kim H, Lee D. Coordinated anatomical and functional variability in the human brain during adolescence. Human Brain Mapping 2022, 44: 1767-1778. PMID: 36479851, PMCID: PMC9921246, DOI: 10.1002/hbm.26173.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingChildCognitionHumansMagnetic Resonance ImagingMyelin SheathSensorimotor CortexConceptsCortical thicknessCortical areasFunctional connectivityResting-state functional connectivityAssociation cortical areasMultiple cortical areasCortical information processingAge-related changesCortical myelinationAdult brainCytoarchitectural featuresBrain developmentInformation processingBrainDevelopmental changesHuman brainAdolescenceMyelinationPatterns of coordinationMeasuresRegional variationMyelin
2021
Functional Connectivity during Encoding Predicts Individual Differences in Long-Term Memory
Lin Q, Yoo K, Shen X, Constable TR, Chun MM. Functional Connectivity during Encoding Predicts Individual Differences in Long-Term Memory. Journal Of Cognitive Neuroscience 2021, 33: 2279-2296. PMID: 34272957, PMCID: PMC8497062, DOI: 10.1162/jocn_a_01759.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingHumansIndividualityMagnetic Resonance ImagingMemory, Long-TermMemory, Short-TermConceptsLong-term memoryN-back taskIndividual differencesFunctional connectivityMemory modelWhole-brain functional connectivity networksSubsequent memory effectsRecognition memory modelsMedial temporal lobeWhole-brain functional networksRetention of informationRecollection memoryRecognition memoryMemory performanceNeural basisFunctional connectivity networksLTM formationFMRI dataTemporal lobeMemoryBrain regionsFunctional networksConnectivity networksTaskLittle predictive power
2020
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2019
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes
Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang JJ. Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz004. PMID: 31511876, PMCID: PMC6936965, DOI: 10.1210/clinem/dgz004.Peer-Reviewed Original ResearchConceptsState functional connectivityHealthy controlsDefault mode networkType 1 diabetes mellitusFunctional connectivityImpact of T1DMAcademic medical centerAngular gyrus connectivityBlood oxygenation levelState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessDiabetes mellitusHypoglycemic clampHypoglycemia awarenessFunctional outcomeMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHC volunteersType 1
2017
Can brain state be manipulated to emphasize individual differences in functional connectivity?
Finn ES, Scheinost D, Finn DM, Shen X, Papademetris X, Constable RT. Can brain state be manipulated to emphasize individual differences in functional connectivity? NeuroImage 2017, 160: 140-151. PMID: 28373122, PMCID: PMC8808247, DOI: 10.1016/j.neuroimage.2017.03.064.Peer-Reviewed Original ResearchConceptsIndividual differencesFunctional connectivityBrain statesIndividual differences researchBrain functional organizationHuman Connectome ProjectDifferences researchBrain activityConnectome ProjectSubject variabilityNetworks of interestBehavioral phenotypesCertain tasksFunctional organizationDefault stateNeutral backdropOutline questionsFuture studiesConnectivityTask
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
2015
Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity
Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, Papademetris X, Constable RT. Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nature Neuroscience 2015, 18: 1664-1671. PMID: 26457551, PMCID: PMC5008686, DOI: 10.1038/nn.4135.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingConnectomeFemaleHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysYoung Adult
2009
Language lateralization in epilepsy patients: fMRI validated with the Wada procedure
Arora J, Pugh K, Westerveld M, Spencer S, Spencer DD, Constable R. Language lateralization in epilepsy patients: fMRI validated with the Wada procedure. Epilepsia 2009, 50: 2225-2241. PMID: 19490042, DOI: 10.1111/j.1528-1167.2009.02136.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVerbal fluency taskWada procedureSentence comprehensionFluency taskLaterality scoresLanguage lateralizationLaterality indexAuditory sentence comprehensionFMRI language mappingAuditory taskReading taskConjunction analysisHemispheric dominanceLateralization scoresFMRI laterality indicesLanguage mappingWada testingMidline regionWada testLateralizationSpecific patient examplesQuantifying activationTaskComprehension
2008
VASO‐based calculations of CBV change: Accounting for the dynamic CSF volume
Scouten A, Constable R. VASO‐based calculations of CBV change: Accounting for the dynamic CSF volume. Magnetic Resonance In Medicine 2008, 59: 308-315. PMID: 18228581, PMCID: PMC2737703, DOI: 10.1002/mrm.21427.Peer-Reviewed Original Research
2007
Applications and limitations of whole‐brain MAGIC VASO functional imaging
Scouten A, Constable R. Applications and limitations of whole‐brain MAGIC VASO functional imaging. Magnetic Resonance In Medicine 2007, 58: 306-315. PMID: 17654574, PMCID: PMC2673534, DOI: 10.1002/mrm.21273.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCerebrospinal fluidBlood Oxygenation Level Dependent (BOLD) imagesAuditory stimulationWhole-brain functional magnetic resonance imagingActivation-induced decreaseCerebral blood volumeMagnetic resonance imagingSuperior temporal gyrusBlood volumeThree-compartment modelResonance imagingCSF contributionTemporal gyrusFunctional imagingVisual stimulation
2006
Brain Connectivity Related to Working Memory Performance
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingFemaleHumansMaleMemoryMiddle AgedNerve NetPsychomotor PerformanceConceptsPosterior cingulate cortexMemory taskCognitive tasksCingulate cortexVentral anterior cingulate cortexDifferent cognitive tasksMedial frontal regionsMedial frontal gyrusDefault mode networkAnterior cingulate cortexFunctional imaging studiesCognitive abilitiesIndividual differencesMemory performanceCognitive performanceFrontal gyrusMode networkFrontal regionsFunctional connectivityBrain connectivityBrain areasTaskFunctional connectionsImaging studiesCortexConnectivity–behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability
Hampson M, Tokoglu F, Sun Z, Schafer RJ, Skudlarski P, Gore JC, Constable RT. Connectivity–behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. NeuroImage 2006, 31: 513-519. PMID: 16497520, DOI: 10.1016/j.neuroimage.2005.12.040.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingFrontal LobeFunctional LateralityHumansMagnetic Resonance ImagingReadingReference Values
2001
Functional MRI of Language Processing: Dependence on Input Modality and Temporal Lobe Epilepsy
Carpentier A, Pugh K, Westerveld M, Studholme C, Skrinjar O, Thompson J, Spencer D, Constable R. Functional MRI of Language Processing: Dependence on Input Modality and Temporal Lobe Epilepsy. Epilepsia 2001, 42: 1241-1254. PMID: 11737158, DOI: 10.1046/j.1528-1157.2001.35500.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAuditory language taskLanguage tasksLanguage processingTask presentationLateralization scoresLanguage comprehension taskVisual language taskModality-specific areasInput modalitiesDifferent input modalitiesMagnetic resonance imagingTemporal lobe epilepsy patientsFMRI resultsBA 44FMRI findingsAuditory inputBroca's areaLanguage areasNeuropsychological testingVisual inputFMRI dataWada testingLanguage localizationAbstract dimensionsPatterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Carpentier A, Constable R, Schlosser M, de Lotbinière A, Piepmeier J, Spencer D, Awad I. Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. Journal Of Neurosurgery 2001, 94: 946-54. PMID: 11409524, DOI: 10.3171/jns.2001.94.6.0946.Peer-Reviewed Original ResearchConceptsFMR imaging activationSurgical interventionRolandic regionMotor cortex plasticityMotor task paradigmFunctional magnetic resonance imagingMotor skillsMagnetic resonance imagingSevere motor impairmentFunctional magnetic resonanceFunctional recoveryLesion sideCortical abnormalitiesMotor cortexControl volunteersCortical malformationsStructural lesionsContralateral hemisphereArteriovenous malformationsBrain lesionsSurgical proceduresMotor impairmentPathological lesionsFunctional reorganizationAuthors' institutionThe Functional Neural Architecture of Components of Attention in Language-Processing Tasks
Shaywitz B, Shaywitz S, Pugh K, Fulbright R, Skudlarski P, Mencl W, Constable R, Marchione K, Fletcher J, Klorman R, Lacadie C, Gore J. The Functional Neural Architecture of Components of Attention in Language-Processing Tasks. NeuroImage 2001, 13: 601-612. PMID: 11305889, DOI: 10.1006/nimg.2000.0726.Peer-Reviewed Original ResearchConceptsInferior frontal sitesFrontal sitesAttentional controlExecutive functionFunctional neural architectureFunctional magnetic resonanceLanguage processing tasksLeft hemisphere sitesSelective attentionPerceptual selectivityRight-handed manParietal sitesRight hemisphereCortical systemsLanguage processingNeural architectureFrontal cortexIncreased activationHemisphere sitesWordsTaskImportant dimensionSpecific functional aspectsAttentionProcessing
2000
Network analysis of brain activations in working memory: Behavior and age relationships
Mencl W, Pugh K, Shaywitz S, Shaywitz B, Fulbright R, Constable R, Skudlarski P, Katz L, Marchione K, Lacadie C, Gore J. Network analysis of brain activations in working memory: Behavior and age relationships. Microscopy Research And Technique 2000, 51: 64-74. PMID: 11002354, DOI: 10.1002/1097-0029(20001001)51:1<64::aid-jemt7>3.0.co;2-d.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingBehaviorBrain MappingFemaleHemodynamicsHippocampusHumansMagnetic Resonance ImagingMemoryMiddle AgedConceptsMedial temporal lobeFunctional magnetic resonance imagingBrain activationTemporal lobeBetter memory performanceInferior frontal gyrusRight medial temporal lobeRight prefrontal regionsMedial frontal cortexInferior temporal lobeMemory recognitionMemory testMemory performanceInferior frontalPrefrontal regionsFrontal gyrusNew stimuliExtrastriate cortexRehearsal periodMemory impairmentBrain scoreOlder subjectsVisual formAge effectsRecognition periodInvestigation of the Human Hippocampal Formation Using a Randomized Event-Related Paradigm and Z-Shimmed Functional MRI
Constable R, Carpentier A, Pugh K, Westerveld M, Oszunar Y, Spencer D. Investigation of the Human Hippocampal Formation Using a Randomized Event-Related Paradigm and Z-Shimmed Functional MRI. NeuroImage 2000, 12: 55-62. PMID: 10875902, DOI: 10.1006/nimg.2000.0583.Peer-Reviewed Original Research