2020
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2009
Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging
Hirshberg B, Qiu M, Cali AM, Sherwin R, Constable T, Calle RA, Tal MG. Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging. Diabetologia 2009, 52: 1561. PMID: 19488737, DOI: 10.1007/s00125-009-1406-8.Peer-Reviewed Original ResearchConceptsType 1 diabetic patientsPancreatic blood flowDiabetic patientsBlood flowIslet massHealthy volunteersPancreatic perfusionArterial spin labeling magnetic resonanceTotal pancreatic blood flowPancreatic beta-cell massConclusions/interpretationOur dataAims/hypothesisLossBeta-cell massMagnetic resonance perfusionSignificant differencesHuman pancreatic isletsDiabetes mellitusVascularised organsIslet functionMurine modelClamp studiesNormal volunteersHealthy individualsPatientsControl tissuesSU‐FF‐J‐140: Multiple Aspects of Approximated‐Returning‐To‐The‐Origin Probability (ARTOP) Diffusion Tensor Imaging for Better Observation High‐Graded Gliomas Treatment Responses
Chu A, Knisely J, Fulbright R, Constable R, Nath R. SU‐FF‐J‐140: Multiple Aspects of Approximated‐Returning‐To‐The‐Origin Probability (ARTOP) Diffusion Tensor Imaging for Better Observation High‐Graded Gliomas Treatment Responses. Medical Physics 2009, 36: 2509-2509. DOI: 10.1118/1.3181432.Peer-Reviewed Original ResearchTreatment responseGlioblastoma patientsGood clinical prognosisEarly treatment responseDiffusion tensorCancer treatment responseClinical prognosisMalignant gliomasEcho-planar sequenceProgressive gliomasSlow diffusion compartmentGlioma cellsGliomasClinical routineHigher ADCPatientsFA mapsMRI modalitiesMultiple aspectsAdaptive treatmentExtracellular spaceTreatmentSensitive toolDenser cellsT magnet
2005
Spatial resolution, signal-to-noise ratio, and smoothing in multi-subject functional MRI studies
Scouten A, Papademetris X, Constable R. Spatial resolution, signal-to-noise ratio, and smoothing in multi-subject functional MRI studies. NeuroImage 2005, 30: 787-793. PMID: 16343951, DOI: 10.1016/j.neuroimage.2005.10.022.Peer-Reviewed Original ResearchConceptsSingle-subject studySpecific cortical regionsFunctional MRI studyBasic neuroscience studiesRandom effects analysisNeurosurgical interventionHemodynamic responseMRI studiesCortical activityCortical regionsFunctional MRIBrain functionFunctional anatomyNeurosurgical planningFunctional mappingSubtle activationClinical environmentGroup-level statisticsNeurophysiological underpinningsPartial volume effectsActivationNeuroscience studiesPatientsGroup statistics
1999
Brain function in spasmodic dysphonia: A functional MRI study
Kumada M, Mencl E, Pugh K, Constable R, Bell‐Berti F, Honorof D, Gracco V. Brain function in spasmodic dysphonia: A functional MRI study. The Journal Of The Acoustical Society Of America 1999, 105: 1247-1247. DOI: 10.1121/1.425983.Peer-Reviewed Original ResearchSpasmodic dysphoniaSD patientsFunctional MRIPhonation of /a/Functional MRI studyExtrapyramidal systemNormal subjectsMRI studiesVocal cordsVocalis muscleMuscle activityBrain functionDysfunctional regionsVocal foldsPatientsSymptomsDysphoniaSubjectsPhonationRegisterHyperadductionDysfunctionHyperabductionChest registerCord
1995
Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization.
Puce A, Constable R, Luby M, McCarthy G, Nobre A, Spencer D, Gore J, Allison T. Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization. Journal Of Neurosurgery 1995, 83: 262-70. PMID: 7616272, DOI: 10.3171/jns.1995.83.2.0262.Peer-Reviewed Original ResearchConceptsSensorimotor cortexFunctional magnetic resonance imagingMagnetic resonance imagingFunctional MR imagingMotor cortexElectrical stimulationResonance imagingMR imagingUseful noninvasive methodSensory tasksRefractory seizuresMedian nerveAxial gradient echo imagesNormal subjectsSensorimotor areasElectrophysiological localizationFunctional assessmentPrimary sensoryCentral sulcusThenar regionCortexMotor tasksNoninvasive methodGradient-echo imagesPatients
1994
BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat
Graham G, Zhong J, Petroff O, Constable R, Prichard J, Gore J. BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat. Magnetic Resonance In Medicine 1994, 31: 557-560. PMID: 8015411, DOI: 10.1002/mrm.1910310514.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientNormal human subjectsMRI changesCerebral perfusionCerebrovascular reserveCerebrovascular diseaseAnatomic mappingRatsMRI monitoringSignificant decreaseHuman subjectsMRI methodsMRI signalHypercarbiaPatientsInhalationPerfusionReactivity patternsAcetazolamideDiseaseAdministration