2018
Control of Spreading Depression with Electrical Fields
Whalen A, Xiao Y, Kadji H, Dahlem M, Gluckman B, Schiff S. Control of Spreading Depression with Electrical Fields. Scientific Reports 2018, 8: 8769. PMID: 29884896, PMCID: PMC5993812, DOI: 10.1038/s41598-018-26986-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebral CortexCortical Spreading DepressionElectric StimulationMaleNeuronsOptical ImagingPotassiumRats, Sprague-DawleyConceptsElectric fieldField polarityDC electric fieldElectric field polarityElectrical controlOptical imagingPropagation pathIntrinsic optical imagingOpposite signDepression propagatesElectrical fieldField terminationElectro-chemical gradientPropagation velocityPropagatesFieldTraumatic brain injuryPropagationConfinementMore superficial layersDepression propagationBrain injurySynaptic transmissionBrain slicesWaves
2014
Oxygen and seizure dynamics: II. Computational modeling
Wei Y, Ullah G, Ingram J, Schiff S. Oxygen and seizure dynamics: II. Computational modeling. Journal Of Neurophysiology 2014, 112: 213-223. PMID: 24671540, PMCID: PMC4064403, DOI: 10.1152/jn.00541.2013.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsMaleModels, NeurologicalNeuronsOxygenPotassiumRatsRats, Sprague-DawleySeizuresSodiumConceptsSeizure eventsTissue oxygen pressureIntense neuronal firingSeizure patternsInhibitory neuronsNeuronal firingEpileptic seizuresSeizuresElectrophysiological recordingsOxygen metabolismSeizure dynamicsMetabolic energy consumptionEnergy metabolismExcitatoryMicroenvironment dynamicsRecent studiesOxygen and seizure dynamics: I. Experiments
Ingram J, Zhang C, Cressman J, Hazra A, Wei Y, Koo Y, Žiburkus J, Kopelman R, Xu J, Schiff S. Oxygen and seizure dynamics: I. Experiments. Journal Of Neurophysiology 2014, 112: 205-212. PMID: 24598521, PMCID: PMC4064411, DOI: 10.1152/jn.00540.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalMaleOxygenPyramidal CellsRatsRats, Sprague-DawleySeizuresConceptsEpileptiform activityRat hippocampal slicesLayer-specific patternsSeizure-like eventsSeizure-like stateSpontaneous seizure-like eventsHippocampal slicesSeizure onsetNeuronal interplayCellular excitabilitySeizure dynamicsEndogenous hypoxiaGreater reductionO2 utilizationHypoxiaElectrical recordingsSeizuresCA1ExcitabilityPyramidale
2013
FRET excited ratiometric oxygen sensing in living tissue
Ingram J, Zhang C, Xu J, Schiff S. FRET excited ratiometric oxygen sensing in living tissue. Journal Of Neuroscience Methods 2013, 214: 45-51. PMID: 23333398, PMCID: PMC3664065, DOI: 10.1016/j.jneumeth.2013.01.002.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsColoring AgentsComputer SystemsConvulsantsFluorescence Resonance Energy TransferGlassHippocampusIn Vitro TechniquesLuminescent MeasurementsMetal NanoparticlesMicroelectrodesOrganoplatinum CompoundsOximetryOxygen ConsumptionPorphyrinsPyramidal CellsQuantum DotsRatsRats, Sprague-DawleySingle-Cell AnalysisConceptsInterstitial oxygen concentrationGlass substratesPolymer matrixBiocompatible sensorsInert polymer matrixDynamic analysisOptical sensorsMatrix consistingTemporal resolutionSensorsMillisecond temporal resolutionOxygen concentrationQuantum dotsMatrixRatiometric oxygenFluorescence resonance energy transferEnergy transfer
2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell typesModulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel roleThe role of inhibition in oscillatory wave dynamics in the cortex
Xiao Y, Huang X, Van Wert S, Barreto E, Wu J, Gluckman B, Schiff S. The role of inhibition in oscillatory wave dynamics in the cortex. European Journal Of Neuroscience 2012, 36: 2201-2212. PMID: 22805065, PMCID: PMC4410882, DOI: 10.1111/j.1460-9568.2012.08132.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicucullineCarbacholEpilepsies, PartialGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABA-B Receptor AgonistsGABA-B Receptor AntagonistsMaleMembrane PotentialsModels, NeurologicalNeocortexNeural InhibitionPicrotoxinRatsRats, Sprague-DawleyReceptors, AMPAReceptors, GABA-AReceptors, GABA-BReceptors, N-Methyl-D-AspartateTheta RhythmConceptsGABAergic inhibitionNeocortical brain slicesVoltage-sensitive dye imagingSprague-Dawley ratsPresence of carbacholConcentration-dependent mannerGABAB antagonistGABAA receptorsBrain slicesTheta frequency oscillationsPharmacological methodsDye imagingCortical oscillationsRole of inhibitionBicucullineDisinhibitionGABAATheta oscillationsCortexBasic spatiotemporal patternsInhibitionNeural information processingCarbacholMental tasksAntagonist
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitabilityTime dependence of stimulation/recording-artifact transfer function estimates for neural interface systems
Chernyy N, Schiff S, Gluckman B. Time dependence of stimulation/recording-artifact transfer function estimates for neural interface systems. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2009, 2009: 1380-1383. PMID: 19964759, PMCID: PMC5502111, DOI: 10.1109/iembs.2009.5334297.Peer-Reviewed Original ResearchConceptsControl systemElectrode interface propertiesLow-frequency electric fieldNeural interface systemInterface propertiesControl outputElectric fieldElectrical potential variationsElectrical currentTransfer function magnitudeImpedance changesSystem stateMeasurement pointsInterface systemFunction magnitudeNeural control systemSimultaneous measurementTime dependencePotential variationPropertiesStimulus artifactTransfer function estimatesSystemFilterCurrent
2008
Multi-taper transfer function estimation for stimulation artifact removal from neural recordings
Chernyy N, Schiff S, Gluckman B. Multi-taper transfer function estimation for stimulation artifact removal from neural recordings. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2008, 2008: 2772-2776. PMID: 19163280, PMCID: PMC3547985, DOI: 10.1109/iembs.2008.4649777.Peer-Reviewed Original Research
2007
Improved sleep–wake and behavior discrimination using MEMS accelerometers
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Improved sleep–wake and behavior discrimination using MEMS accelerometers. Journal Of Neuroscience Methods 2007, 163: 373-383. PMID: 17481736, PMCID: PMC2279268, DOI: 10.1016/j.jneumeth.2007.03.007.Peer-Reviewed Original Research
2006
Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals
Sunderam S, Chernyy N, Mason J, Peixoto N, Weinstein S, Schiff S, Gluckman B. Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 1612-1615. PMID: 17946910, PMCID: PMC3547984, DOI: 10.1109/iembs.2006.259454.Peer-Reviewed Original Research
2005
Control of Traveling Waves in the Mammalian Cortex
Richardson K, Schiff S, Gluckman B. Control of Traveling Waves in the Mammalian Cortex. Physical Review Letters 2005, 94: 028103. PMID: 15698234, PMCID: PMC1513188, DOI: 10.1103/physrevlett.94.028103.Peer-Reviewed Original Research
2004
Spiral Waves in Disinhibited Mammalian Neocortex
Huang X, Troy W, Yang Q, Ma H, Laing C, Schiff S, Wu J. Spiral Waves in Disinhibited Mammalian Neocortex. Journal Of Neuroscience 2004, 24: 9897-9902. PMID: 15525774, PMCID: PMC4413915, DOI: 10.1523/jneurosci.2705-04.2004.Peer-Reviewed Original Research
2003
Sensitivity of Neurons to Weak Electric Fields
Francis J, Gluckman B, Schiff S. Sensitivity of Neurons to Weak Electric Fields. Journal Of Neuroscience 2003, 23: 7255-7261. PMID: 12917358, PMCID: PMC6740448, DOI: 10.1523/jneurosci.23-19-07255.2003.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCells, CulturedElectric StimulationElectricityNerve NetNeuronsPyramidal CellsRatsRats, Sprague-DawleyIn Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields
Richardson K, Gluckman B, Weinstein S, Glosch C, Moon J, Gwinn R, Gale K, Schiff S. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 2003, 44: 768-777. PMID: 12790889, DOI: 10.1046/j.1528-1157.2003.35402.x.Peer-Reviewed Original ResearchMeSH KeywordsAmplifiers, ElectronicAnimalsDisease Models, AnimalElectric StimulationElectric Stimulation TherapyElectrodes, ImplantedElectronics, MedicalEpilepsyHippocampusHumansKainic AcidKindling, NeurologicMaleMembrane PotentialsMicroelectrodesRatsRats, Sprague-DawleySeizuresStereotaxic TechniquesConceptsElectric field modulationRadial electric fieldElectric fieldElectric field controlField modulationMicroelectrode pairsCharge deliveryControl systemElectrode geometryField controlSeizure onset detectionElectrodeElectric field stimulationElectronicsStimulation electrodesFieldFirst resultsNovel approachExperiments
2001
Adaptive Electric Field Control of Epileptic Seizures
Gluckman B, Nguyen H, Weinstein S, Schiff S. Adaptive Electric Field Control of Epileptic Seizures. Journal Of Neuroscience 2001, 21: 590-600. PMID: 11160438, PMCID: PMC6763796, DOI: 10.1523/jneurosci.21-02-00590.2001.Peer-Reviewed Original Research
1996
Electric field suppression of epileptiform activity in hippocampal slices
Gluckman B, Neel E, Netoff T, Ditto W, Spano M, Schiff S. Electric field suppression of epileptiform activity in hippocampal slices. Journal Of Neurophysiology 1996, 76: 4202-4205. PMID: 8985916, DOI: 10.1152/jn.1996.76.6.4202.Peer-Reviewed Original Research
1995
Periodic pacing an in vitro epileptic focus
Jerger K, Schiff S. Periodic pacing an in vitro epileptic focus. Journal Of Neurophysiology 1995, 73: 876-879. PMID: 7760143, DOI: 10.1152/jn.1995.73.2.876.Peer-Reviewed Original Research
1994
Stochastic versus deterministic variability in simple neuronal circuits: II. Hippocampal slice
Schiff S, Jerger K, Chang T, Sauer T, Aitken P. Stochastic versus deterministic variability in simple neuronal circuits: II. Hippocampal slice. Biophysical Journal 1994, 67: 684-691. PMID: 7948681, PMCID: PMC1225410, DOI: 10.1016/s0006-3495(94)80527-2.Peer-Reviewed Original ResearchConceptsInput-output time seriesEvidence of determinismTime seriesNonlinear predictionDeterministic variabilitySimple neuronal circuitLong time seriesSurrogate dataPresynaptic volley amplitudeStatistical controlFlow approachDiscrete adaptationDispersion approachInput-output functionAmplitudeSingle instanceApproach