2017
Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda
Kulkarni A, Schiff S, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, MacDonald M, Cherukuri V, Warf B. Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda. New England Journal Of Medicine 2017, 377: 2456-2464. PMID: 29262276, PMCID: PMC5784827, DOI: 10.1056/nejmoa1707568.Peer-Reviewed Original ResearchConceptsETV-CPCPostinfectious hydrocephalusUgandan infantsTreatment failureCognitive outcomesBrain volumeSingle-center studyEndoscopic third ventriculostomyChoroid plexus cauterizationMajor health problemSignificant differencesLanguage scoresSecondary outcomesEndoscopic treatmentPrimary outcomeVentricular sizeThird ventriculostomyInfant hydrocephalusComputed tomographyTreatment groupsAlternative treatmentLate failureBayley ScalesBrain growthConventional treatment
2014
Volumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus.
Mandell J, Kulkarni A, Warf B, Schiff S. Volumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus. Journal Of Neurosurgery Pediatrics 2014, 15: 125-32. PMID: 25431901, DOI: 10.3171/2014.9.peds12427.Peer-Reviewed Original ResearchConceptsFrontal-occipital horn ratioNeurocognitive outcomesBrain volumeCSF volumeFluid volumePediatric patientsBrain developmentEvaluation of hydrocephalusGoal of treatmentSmaller brain volumesLower cognitive outcomesPoor neurocognitive outcomesNormal brain developmentLarge fluid volumesHealthy brain developmentVolumetric brain analysisSurgical treatmentVentricular sizeHydrocephalic patientsCT scanHydrocephalusPatientsBayley ScalesBrain growthFine motor