2000
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
Shao C, Deng L, Henegariu O, Liang L, Stambrook P, Tischfield J. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7405-7410. PMID: 10861008, PMCID: PMC16558, DOI: 10.1073/pnas.97.13.7405.Peer-Reviewed Original ResearchConceptsGenetic instabilityChromosome instabilityP53-null miceP53 tumor suppressor proteinMultiple cellular processesCell cycle checkpointsTumor suppressor proteinSomatic cell variantsNormal cellsNull miceCellular processesCycle checkpointsGenetic variationMitotic recombinationSuppressor proteinEpigenetic alterationsInterstitial deletionLOH eventsCell deathLoss of heterozygosityP53 functionFibroblast coloniesPoint mutationsFunctional p53Tumor initiation
1999
Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice
Shao C, Deng L, Henegariu O, Liang L, Raikwar N, Sahota A, Stambrook P, Tischfield J. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 9230-9235. PMID: 10430925, PMCID: PMC17762, DOI: 10.1073/pnas.96.16.9230.Peer-Reviewed Original ResearchMeSH KeywordsAdenine PhosphoribosyltransferaseAnimalsChromosome MappingCrosses, GeneticEar, ExternalExonsFemaleFibroblastsGenes, RecessiveGenetic VariationHeterozygoteHumansLoss of HeterozygosityMaleMiceMice, Inbred C3HMice, Inbred StrainsMice, Mutant StrainsMutagenesisPoint MutationRecombination, GeneticSkinT-LymphocytesConceptsMitotic recombinationPolymorphic molecular markersSomatic cell variantsProgeny of crossesFrequency of crossoversHigh spontaneous frequencyAPRT enzyme activitySomatic mutagenesisMap distanceCytological markersSelection mediumHuman peripheral T cellsMolecular markersChromosome 8Vivo lossCell coloniesAPRTEnzyme activityNormal fibroblastsRecombinationHeterozygous micePeripheral T cellsAdenine analogueHeterozygote miceVivo