Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
Bertino F, Mukherjee D, Bonora M, Bagowski C, Nardelli J, Metani L, Venturini D, Chianese D, Santander N, Salaroglio I, Hentschel A, Quarta E, Genova T, McKinney A, Allocco A, Fiorito V, Petrillo S, Ammirata G, De Giorgio F, Dennis E, Allington G, Maier F, Shoukier M, Gloning K, Munaron L, Mussano F, Salsano E, Pareyson D, di Rocco M, Altruda F, Panagiotakos G, Kahle K, Gressens P, Riganti C, Pinton P, Roos A, Arnold T, Tolosano E, Chiabrando D. Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus. Cell Reports Medicine 2024, 5: 101647. PMID: 39019006, PMCID: PMC11293339, DOI: 10.1016/j.xcrm.2024.101647.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusCalcium handlingNeural progenitor cellsMitochondrial calcium handlingMouse neural progenitor cellsFLVCR1 geneMitochondrial calcium levelsVentricular dilatationLive birthsCalcium levelsProgenitor cellsClinical challengeVentricle enlargementPathogenetic mechanismsSevere formCortical neurogenesisNeural progenitorsFLVCR1aMitochondria-associated membranesHydrocephalusMiceFLVCR1CH genesMolecular mechanismsMetabolic activityAlgebraic Nexus of Fibonacci Forms and Two-Simplex Topology in Multicellular Morphogenesis
Hoyos W, Loarca H, Kahle K, Williams Z, Lamb E, Alcántara J, Kinane T, Cuevas L. Algebraic Nexus of Fibonacci Forms and Two-Simplex Topology in Multicellular Morphogenesis. Symmetry 2024, 16: 516. DOI: 10.3390/sym16050516.Peer-Reviewed Original ResearchMulticellular organismsCellular growth propertiesMulticellular morphogenesisInhibition of replicationSynthetic biologyMulticellular structuresTubular formContact inhibitionMolecular mechanismsCellular aggregatesGrowth propertiesMorphogenesisMultiple stepsFibonacci patternCell replicationReplicationCellular genesisCellsCellular arrangementPhylogenyGrowth patternMolecular propertiesAdhesionOrganizationMechanism