2021
The genetic structure of the Turkish population reveals high levels of variation and admixture
Kars ME, Başak AN, Onat OE, Bilguvar K, Choi J, Itan Y, Çağlar C, Palvadeau R, Casanova JL, Cooper DN, Stenson PD, Yavuz A, Buluş H, Günel M, Friedman JM, Özçelik T. The genetic structure of the Turkish population reveals high levels of variation and admixture. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2026076118. PMID: 34426522, PMCID: PMC8433500, DOI: 10.1073/pnas.2026076118.Peer-Reviewed Original ResearchConceptsGenetic structureTR populationGenome-wide association studiesRuns of homozygosityGenomes Project populationsHigh inbreeding coefficientsDisease gene discoveryHigh-quality haplotypesPotential medical relevanceGene discoveryExtensive admixturePhenotypic consequencesWhole genomeGenetic basisInbreeding coefficientSpecific genesRare rangeGenome variantsAssociation studiesGenetic relationshipsFunctional consequencesWhole exomeSpecific phenotypesGenotype imputationMedical relevance
2018
Clonal evolution analysis of paired anaplastic and well‐differentiated thyroid carcinomas reveals shared common ancestor
Dong W, Nicolson NG, Choi J, Barbieri AL, Kunstman JW, Azar S, Knight J, Bilguvar K, Mane SM, Lifton RP, Korah R, Carling T. Clonal evolution analysis of paired anaplastic and well‐differentiated thyroid carcinomas reveals shared common ancestor. Genes Chromosomes And Cancer 2018, 57: 645-652. PMID: 30136351, DOI: 10.1002/gcc.22678.Peer-Reviewed Original ResearchConceptsCommon ancestorProgression of ATCClonal evolution analysisEvolutionary lineagesGenetic relationshipsAnaplastic thyroid carcinomaClonal analysisAncestorEvolution analysisPrivate mutationsMutationsATC tumorsLineal relationshipLineagesNormal tissuesThyroid carcinomaLandscapeFollicular thyroid carcinomaPairs