2013
LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Yeung JT, Hamilton RL, Ohnishi K, Ikeura M, Potter DM, Nikiforova MN, Ferrone S, Jakacki RI, Pollack IF, Okada H. LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma. Clinical Cancer Research 2013, 19: 1816-1826. PMID: 23401227, PMCID: PMC3618546, DOI: 10.1158/1078-0432.ccr-12-2861.Peer-Reviewed Original ResearchConceptsHLA class IT cell infiltrationHLA class IILoss of heterozygosityHLA class IIIClass IOverall survivalAdult glioblastomaClass IIIHLA class I expressionHuman leukocyte antigen (HLA) class IClass IIEfficacy of immunotherapyShorter overall survivalCytotoxic T cellsClass I expressionAntigen class ICross-sectional analysisAdult patientsShorter survivalImmunohistochemical evaluationT cellsHLA class I regionI expressionDownregulated expression
2012
Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy
Yeung JT, Hamilton RL, Okada H, Jakacki RI, Pollack IF. Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy. Journal Of Neuro-Oncology 2012, 111: 103-111. PMID: 23179498, PMCID: PMC3546121, DOI: 10.1007/s11060-012-0998-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAntigens, NeoplasmBrainBrain NeoplasmsCancer VaccinesChildChild, PreschoolEpendymomaFemaleGene Expression Regulation, NeoplasticHistocompatibility Antigens Class IHumansInfantInhibitor of Apoptosis ProteinsInterleukin-13 Receptor alpha1 SubunitMaleMiddle AgedReceptor, EphA2SurvivinWT1 ProteinsConceptsTumor-associated antigensMore tumor-associated antigensIL-13Rα2Positive stainingAdult ependymomasMultiple peptides vaccineNormal brain tissueGlioma vaccinesImmunotherapy approachesVaccine therapyPediatric casesAdult casesTumor recurrenceClinical trialsPeptide vaccinePediatric ependymomaNormal brainEpendymomaBrain tissuePediatric gliomasTumor 1SurvivinStainingEphA2Vaccine