2023
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnset
1990
Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons
Blumenfeld H, Spiral M, Kandel E, Siegelbaum S. Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons. Neuron 1990, 5: 487-499. PMID: 1976321, DOI: 10.1016/0896-6273(90)90088-w.Peer-Reviewed Original ResearchConceptsAplysia sensory neuronsAction potentialsSensory neuronsIndicator dye fura-2Sensory neuron terminalsDye fura-2Modulation of Ca2Presynaptic inhibitionInhibitory transmitterNeuron terminalsPresynaptic facilitationCalcium influxFura-2Intracellular injectionIntracellular Ca2Transient riseInternal Ca2Time courseNeuronsFMRFamideCa2InfluxSerotonin